Abstract
Amphetamine-induced lateralized activity (rotation) and nonlateralized activity (extra quarter turns) was classically conditioned in female rats using the test environment as the conditioned stimulus (CS) and 1.25 mg/kg d-amphetamine as the unconditioned stimulus. Conditioned lateralized activity extinguished more rapidly than nonlateralized activity. Also, d-amphetamine-induced nonlateralized activity was selectively decreased by a schedule of 50% partial reinforcement. These results indicate that the two d-amphetamine responses can be distinguished, that they are differentially affected by learning, and that a schedule of partial reinforcement can selectively attenuate one effect of a drug while leaving the other intact. In addition, haloperidol blocked conditioned lateralized activity; this suggests that the conditioned response may be, like the drug-induced response, mediated by dopamine.
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References
Barr GA, Sharpless NS, Cooper S, Schiff SR, Peredes W, Bridger WH (1983) Classical conditioning, decay and extinction of cocaine-induced hyperactivity and stereotypy. Life Sci 3:1341–1351
Becker JB, Robinson TE, Lorenz KA (1982) Sex differences and estrous cycle variations in amphetamine-elicited rotational behavior. Eur J Pharmacol 80:65–72
Beninger RJ, Hahn BL (1983) Pimozide blocks establishment but not expression of amphetamine-produced environment-specific conditioning. Science 220:1304–1306
Brass CA, Glick SD (1981) Sex differences in drug-induced rotation in two strains of rats. Brain Res 223:229–234
Carey RJ (1986) Conditioned rotational behavior in rats with unilateral 6-hydroxydopamine lesions of the substantia nigra. Brain Res 365:379–382
Eikelboom R, Stewart J (1979) Conditioned temperature effects using morphine as the unconditioned stimulus. Psychopharmacology 61:31–38
Eikelboom R, Stewart J (1981) Conditioned temperature effects using amphetamine as the unconditioned stimulus. Psychopharmacology 75:96–97
Elias JW, Yandell LR, Graff R, Albrecht JW, Smith CJ (1983) Short term augmentation of amphetamine-induced rotation bias. Physiol Behav 31:639–642
Glick SD, Jerussi TP (1974) Spatial and paw preference in rats: their relationship to rate-dependent effects of d-amphetamine. J Pharmacol Exp Ther 188(3):714–725
Glick SD, Cox RD (1978) Nocturnal rotation in normal rats: correlation with amphetamine-induced rotation and effects of nigrostriatal lesions. Brain Res 150:149–161
Glick SD, Shapiro RM (1985) Functional and neurochemical mechanisms of cerebral lateralization in rats. In: Glick SD (ed) Cerebral lateralization in nonhuman species. Academic, New York, pp 157–183
Glick SD, Jerussi TP, Waters DH, Green JP (1974) Amphetamine-induced changes in striatal dopamine and acetylcholine levels and relationship to rotation (circling behavior) in rats. Biochem Pharmacol 23:3223–3225
Glick SD, Jerussi TP, Zimmerberg B (1977) Behavioral and neuropharmacological correlates of nigrostriatal asymmetry in rats. In: Harnad SR, Doty RW, Goldstein L, Jaynes J, Krauthamer G (eds) Lateralization in the nervous system. Academic, New York, pp 213–249
Goldberg SR (1976) Conditioned behavioral and physiological changes associated with injections of a narcotic antagonist in morphine-dependent monkeys. Pavolv J Biol Sci 11(1):203–221
Greenstein S, Glick SD (1975) Improved automated apparatus for recording rotation (circling behavior) in rats or mice. Pharmacol Biochem Behav 3:507–510
Jerussi TP, Glick SD (1976) Drug-induced rotation in rats without lesions: behavioral and neurochemical indices of a normal asymmetry in nigro-striatal function. Psychopharmacology 47:249–260
Mackintosh NJ (1974) The psychology of animal learning. Academic, New York
Miksic S, Smith N, Numan R, Lal H (1975) Acquisition and extinction of a conditioned hyperthermic response to a tone paired with morphine administration. Neuropsychobiology 1(5):277–283
O'Brien CP, Testa T, O'Brien TJ, Brady JP, Wells B (1977) Conditioned narcotic withdrawl in humans. Science 195:1000–1002
Post RM, Lockfeld A, Squillace KM, Contel NR (1981) Drug-environment interaction: context dependency of cocaine-induced behavioral sensitization. Life Sci 28:755–760
Robinson TE (1984) Behavioral sensitization: Characterization of enduring changes in rotational behavior produced by intermittent injections of amphetamine in male and female rats. Psychopharmacology 84:466–475
Robinson TE, Becker JB, Ramirez VD (1980) Sex differences in amphetamine-elicited rotational behavior and the lateralization of striatal dopamine in rats. Brain Res Bull 5:539–545
Robinson TE, Becker JB, Presty SK (1982) Long-term facilitation of amphetamine-induced rotational behavior and striatal dopamine release produced by a single exposure to amphetamine: sex differences. Brain Res 253:231–241
Schiff SR (1982) Conditioned dopaminergic activity. Biol Psychiatry 17(2):135–154
Segal DA, Mandell AJ (1974) Long-term administration of d-amphetamine: progressive augmentation of motor activity and stereotype. Pharmacol Biochem Behav 2:249–255
Siegel S (1976) Morphine analgesic tolerance: its situation specificity supports a pavlovian conditioning model. Science 193:323–325
Siegel S (1977) Morphine tolerance acquisition as an associative process. J Exp Psychol [Anim Behav] 3(1):1–13
Tilson HA, Rech RH (1973) Conditioned drug effects and absence of tolerance to d-amphetamine induced motor activity. Pharmacol Biochem Behav 1:149–153
Wikler A, Pescor FT (1967) Classical conditioning of a morphine abstinence phenomenon, reinforcement of opioid-drinking behavior and “relapse” in morphine-addicted rats. Psychopharmacologia 10:255–284
de Wit H, Stewart J (1981) Reinstatement of cocaine-reinforced responding in the rat. Psychopharmacology 75:134–143
Zar JH (1984) Biostatistical analysis. Prentice-Hall, New Jersey, pp 190–191
Zimmerberg B, Glick SD, Jerussi TP (1974) Neurochemical correlate of a spatial preference in rats. Science 185:623–625
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Drew, K.L., Glick, S.D. Classical conditioning of amphetamine-induced lateralized and nonlateralized activity in rats. Psychopharmacology 92, 52–57 (1987). https://doi.org/10.1007/BF00215479
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DOI: https://doi.org/10.1007/BF00215479