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Effect of phosphatidylcholine vesicles on the activity of DNA polymerase-α

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Summary

Phosphatidylcholine vesicles stimulate the activity of the DNA polymerase-α from calf thymus. This effect is dependent upon the way of addition of the Mg ions, and the extent of the 3H-dTTP incorporation is closely related to the concentration of the vesicles. A role of phospholipids on the activity of the DNA-related enzymes is suggested.

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Author notes

  1. F. A. Manzoli

    Present address: Istituto di Anatomia Umana Normale, Facoltà di Medicina, Via Irnerio, 48. 40126, Bologna, Italy

Authors and Affiliations

  1. Istituti di Anatomia Umana Normale, Facoltà di Medicina, Università di Bologna e Chieti, Bologna, Italy

    S. Capitani, G. Mazzotti, R. Jovine, S. Papa, N. M. Maraldi & F. A. Manzoli

  2. Istituti di Istologia ed Embriologia generale, Facoltà di Medicina, Università di Bologna ed Ancona, Bologna, Italy

    S. Capitani, G. Mazzotti, R. Jovine, N. M. Maraldi & F. A. Manzoli

Authors
  1. S. Capitani
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  2. G. Mazzotti
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  3. R. Jovine
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  4. S. Papa
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  5. N. M. Maraldi
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  6. F. A. Manzoli
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Capitani, S., Mazzotti, G., Jovine, R. et al. Effect of phosphatidylcholine vesicles on the activity of DNA polymerase-α. Mol Cell Biochem 27, 135–138 (1979). https://doi.org/10.1007/BF00215361

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  • DOI: https://doi.org/10.1007/BF00215361

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