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Acetylcholine-evoked uncoupling restricts the passage of Lucifer Yellow between pancreatic acinar cells

Cell and Tissue Research volume 225, pages 633–638 (1982)Cite this article

Summary

Direct cell to cell movement of the fluorescent dye Lucifer Yellow CH (457 daltons) in exocrine acinar tissue is demonstrated by direct observation of living mouse pancreatic segments. Electrical uncoupling of pancreatic acinar cells by local application of a high concentration of acetylcholine significantly restricts cell to cell passage of the fluorescent dye. This result shows that a secretagogue can control direct movement of organic molecules between cells through junctional channels.

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Affiliations

  1. The Physiological Laboratory, University of Liverpool, Liverpool, Great Britain

    I. Findlay &  O. H. Petersen

Authors
  1. I. Findlay
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  2. O. H. Petersen
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Findlay, I., Petersen, O.H. Acetylcholine-evoked uncoupling restricts the passage of Lucifer Yellow between pancreatic acinar cells. Cell Tissue Res. 225, 633–638 (1982). https://doi.org/10.1007/BF00214809

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  • DOI: https://doi.org/10.1007/BF00214809

Key words

  • Intercellular communication
  • Acinar cells
  • Lucifer Yellow
  • Uncoupling