Summary
Two populations of neurons displaying somatostatin-like immunoreactivity were detected immunohistochemically in the guinea pig striatum using a monoclonal antibody. Sparse, well-stained neurons similar to those described in other species were observed throughout the guinea pig caudate-putamen. These neurons contained both neuropeptide Y and NADPH-diaphorase in addition to somatostatin. A second large population of somatostatin immunoreactive neurons in which these other substances did not coexist was found within the putamen.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bennett-Clarke CA, Joseph SA (1986) Immunocytochemical localization of somatostatin in human brain. Peptides 7:877–884
Bennett-Clarke C, Romagnano MA, Joseph SA (1980) Distribution of somatostatin in the rat brain: telencephalon and diencephalon. Brain Res 188:473–486
Brazeau P, Vale W, Burgus R, Ling N, Butcher M, Rivier J, Guillemin R (1973) Hypothalamic polypeptide that inhibits the secretin of immunoreactive pituitary growth hormone. Science 179:77–79
Chesselet MF, Graybiel AM (1986) Striatal neurons expressing somatostatin-like immunoreactivity: evidence for a peptidergic interneuronal system in the cat. Neuroscience 17:547–571
DiFiglia M, Aronin N (1982) Ultrastructural features of immunoreactive somatostatin neurons in the rat caudate nucleus. J Neurosci 2:1267–1274
Hsu SM, Raine L, Ganger H (1981) The use of avidin-biotin-peroxidase comples (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29:577–580
Johansson O (1978) Localization of somatostatin-like immunoreactivity in the Golgi apparatus of central and peripheral neurons. Histochemistry 58:167–176
Johansson O, Hökfelt T, Elde RP (1984) Immunohistochemical distribution of somatostatin-like immunoreactivity in the central nervous system of the adult rat. Neuroscience 13:265–339
Nakamura S, Vincent SR (1986) Somatostatin- and neuropeptide Y-immunoreactive neurons in the neocortex in senile dementia of Alzheimer's type. Brain Res 370:11–20
Papadopoulos GC, Karamanlidis AN, Dinopoulos A, Antonopoulos J (1986) Somatostatinlike immunoreactive neurons in the hedgehog (Erinaceus europaeus) and the sheep (Ovis aries) central nervous system. J Comp Neurol 244:174–192
Smith Y, Parent A (1986) Neuropeptide Y-immunoreactive neurons in the striatum of cat and monkey: morphological characteristics, intrinsic organization and co-localization with somatostatin. Brain Res 372:241–252
Takagi H, Somogyi P, Somogyi J, Smith AD (1983) Fine structural studies on a type of somatostatin-immunoreactive neuron and its synaptic connections in the rat neostriatum: a correlated light and electron microscopic study. J Comp Neurol 214:1–16
Vincent SR, Skirboll L, Hökfelt T, Johansson O, Lundberg JM, Elde RP, Terenius L, Kimmel J (1982) Coexistence of somatostatin- and avian pancreatic polypeptide (APP)-like immunoreactivity in some forebrain neurons. Neuroscience 7:439–446
Vincent SR, Johansson O, Hökfelt T, Skirboll L, Elde RP, Terenius L, Kimmel J, Goldstein M (1983) NADPH-diaphorase: a selective histochemical marker for striatal neurons containing both somatostatin- and avian pancreatic polypeptide (APP)-like immunoreactivities. J Comp Neurol 217:252–263
Vincent SR, McIntosh CHS, Buchan AMJ, Brown JC (1985) Central somatostatin systems revealed with monoclonal antibodies. J Comp Neurol 238:169–187
Zamboni L, de Martino C (1967) Buffered picric acid formaldehyde: a new rapid fixative for electron microscopy. J Cell Biol 148A:35
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Vincent, S.R., von Krosigk, M. Two populations of somatostatin-immunoreactive neurons in the guinea pig striatum. Cell Tissue Res. 252, 219–222 (1988). https://doi.org/10.1007/BF00213846
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00213846