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Genotoxic risk assessment of drinking water consumed in the city of Tehran, Iran

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Abstract

Two hundred liters of drinking water of the city of Tehran were collected as tap water in a glass container and passed through a XAD-2® resin column at a flow rate of 60–100 ml/minute. The adsorbed materials were eluted with acetone, dried and dissolved in 2 ml dimethylsulfoxide (DMSO). Doses up to 10 μl did not elevate sister chromatid exchanges (SCE) in CHO fibroblasts, while 20 μl caused a significant increase in SCE. However, this dose did not show any chromosomal aberration (CA) in V79 fibroblasts. Doses up to 50 μl of the extract did not increase his + spontaneous revertant colonies in Salmonella typhimurium tester strain TA98, TA100 and TA102 in the absence of S9 metabolizing mixture, neither induced DNA alkaline labile sites in V79 fibroblasts.

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References

  • Bellar TA, Lichtenberg JJ, Kroner RC (1974) The occurrence of organohalides in chlorinated drinking water. J Amer Water Works Assoc 66:703–706

    Google Scholar 

  • Bull RJ, Robinson M, Meier JR, Stober J (1982) Use of biological assay systems to assess the relative carcinogenic hazards of disinfection by-products. Environ Hlth Perspect 46:215–227

    Google Scholar 

  • Cantor KP, Hoover R, Hartge P, Mason TJ, Silverman DT, Altman R, Austin DF, Child MA, Key CR, Marrett LD, Myers MH, Narayana AS, Levin LT, Sullivan JW, Swanson GM, Thomas DB, West DW (1987) Bladder cancer and drinking water consumption: A case-control study. J Nat Cancer Inst 79:1269–1279

    Google Scholar 

  • Carrano AV, Thompson LH, Lindl PA, Minkler JL (1978) Sister chromatid exchanges as an indicator of mutagenesis. Nature (Lond) 271:551–553

    Google Scholar 

  • Dean BJ, Danford N (1984) Assays for the detection of chemically induced chromosomal damage in cultured mammalian cells. In: Venitt S, Parry JM (eds) Mutagenicity testing: A practical approach. IRL Press, Oxford, p 187

    Google Scholar 

  • Deen DF, Morgan WF, Tofilon P, Barcellos-Hoff MH (1989) Measurement of sister chromatid exchanges and their relationship to DNA damage, repair and cell killing. Pharmac Therap 42:349–360

    Google Scholar 

  • Durkacz BW, Omidiji O, Gray DA, Shall S (1980) (ADP-ribose)n participates in DNA excision repair. Nature (Lond) 283:593–596

    Google Scholar 

  • Edelman JR, Lin YJ (1986) Simplified differential staining of mouse sister chromatids. Cytobios 46:147–154

    Google Scholar 

  • Evans HJ (1982) sister chromatid exchanges and disease states in man. In: Wolff S (ed) Sister chromatid exchanges. John Wiley and Sons, NY, p 183

    Google Scholar 

  • Farzaneh F, Zalin R, Brill D, Shall S (1982) DNA strand breaks and ADP-ribosyltransferase activation during cell differentiation. Nature (London) 300:362–366

    Google Scholar 

  • Harris CC (1987) Human tissues and cells in carcinogenesis research. Cancer Res 47:1–10

    Google Scholar 

  • International Agency for Research on Cancer (1991) Chlorinated drinking water; chlorination by-products; some other halogenated compounds; cobalt and cobalt compounds. IARC Monogr Environ Carcino Risk Human Lyon, 52

  • Kool HJ, Van Kriji CF, De Greef E, Van Kranen HJ (1982a) Presence, induction and removal of mutagenic activity during the preparation of drinking water in the Netherlands. Environ Hlth Perspect 46:207–214

    Google Scholar 

  • Kool HJ, Van Kriji CF, Zoeteman BCJ (1982b) Toxicity assessment of organic compounds in drinking water. CRC Crit Rev Environ Control 12:307–357

    Google Scholar 

  • Kool HJ, Van Kriji CF (1984) Formation and removal mutagenic during drinking water preparation. Water Res 18:1011–1016

    Google Scholar 

  • Latt SA, Allen J, Bloom SE, Carrano A, Falke E, Kram D, Schneider E, Schreck R, Tice R, Whitefield B, Wolff S (1981) Sister chromatid exchanges: A report of the Gene-tox Program. Mutat Res 87:17–62

    Google Scholar 

  • Li Y, Zhang W, Noblitt TW, Dunipace AJ, Stooket GK (1989) Genotoxic evaluation of chronic fluoride exposure, sister chromatid exchange study. Mutat Res 227:159–165

    Google Scholar 

  • Maron DM, Ames BN (1983) Revised methods for the Salmonella mutagenicity test. Mutat Res 113:173–215

    Google Scholar 

  • Meier J (1990) Mutagens in chlorinated water. Mutation and the Environment Part E, Wiley-Liss, NY p 11

    Google Scholar 

  • Perry P, Evans HJ (1975) Cytological detection of mutagen-carcinogen exposure by sister chromatid exchanges. Nature (London) 258:121–125

    Google Scholar 

  • Perry P, Henderson L, Kirkland D (1984) Sister chromatid exchange in cultured cells. In: Dean BJ (ed) Report of the UKEMS sub-committee on guidelines for mutagenicity testing, Part II United Kingdom Environmental Society, United Kingdom, p 89

    Google Scholar 

  • Pieterse MJ (1988) The potential health risk of trihalomethanes in drinking water, Perspective. South Afr J Sci 84:166–170

    Google Scholar 

  • Rook JJ (1974) Formation of haloform during chlorination of natural waters. J Soc Water Treat Exam 23:234–243

    Google Scholar 

  • Sideris EG, Charalambous SC, Tsolomyty A, Katsaros N (1988) Mutagenesis, carcinogenesis and the metal elements-DNA interaction. In: Trifiates GP, Prassad KN (eds) Nutrition, growth and cancer. Progress in Clinical and Biological Research, AR Liss, NY, p 13

    Google Scholar 

  • Thomas RD (1989) Epidemiological and toxicology of volatile organic chemical contaminants in water absorbed through the skin. J Amer Coll Toxicol 8:779–795

    Google Scholar 

  • Varga CS (1988) Chlorinated drinking water XAD isolates do not affect the sister chromatid exchange frequency. Int Arch Occup Environ Health 61:147–149

    Google Scholar 

  • Velema JP (1987) Contaminated drinking water as potential cause of cancer in humans. Environmental carcinogen reviews, J Environ Sci Health C5(1):1–28

    Google Scholar 

  • Wilcox P, Williamson S (1986) Mutagenic activity of concentrated drinking water samples. Environ Hlth Perspect 69:141–149

    Google Scholar 

  • Wilcox P, Williamson S, Lodge DC, Bootman J (1988) Concentrated drinking water extracts, which cause bacterial mutation and chromosome damage in CHO cells, do not induce sex-linked recessive lethal mutations in Drosophilla. Mutagen 3:381–387

    Google Scholar 

  • Wolff S, Perry P (1974) Differential staining sister chromatid and study of sister chromatid exchange without autoradiography. Chromosoma 48:341–353

    Google Scholar 

  • Yamada K, Hanooka H, Yamada M (1985) Effect of aphidicoline and/or 2′,3′-dideoxythymidine on DNA repair induced in HeLa cells by four types of DNA-damaging agents. J Biol Chem 260:10412–10417

    Google Scholar 

  • Yamasaki E, Ames BN (1977) Concentration of mutagens from urine by adsorption with the nonpolar resin XAD-2: Cigarette smokers have mutagenic urine. Proc Nat Acad Sci USA 74:3555–3559

    Google Scholar 

  • Zoeteman BCJ, Hrubec J, DeGreef J, Kool HJ (1982) Mutagenic activity associated with by-products of drinking water disinfection by chlorine, chlorine dioxide, ozone and UV-irradiation. Environ Hlth Perspect 46:197–205

    Google Scholar 

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Authors and Affiliations

  1. Institute of Biochemistry and Biophysics, University of Tehran, P. O. Box 13145-1384, Tehran, Iran

    F. Sabouni & A. -A. Zia'ee

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  1. F. Sabouni
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  2. A. -A. Zia'ee
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Sabouni, F., Zia'ee, A.A. Genotoxic risk assessment of drinking water consumed in the city of Tehran, Iran. Arch. Environ. Contam. Toxicol. 28, 391–395 (1995). https://doi.org/10.1007/BF00213118

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  • DOI: https://doi.org/10.1007/BF00213118

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