Skip to main content
SpringerLink
Log in

Modulation of the adherence of human polymorphonuclear leukocytes by cadmium and nickel: Sexual differences

  • Published:
Archives of Environmental Contamination and Toxicology Aims and scope Submit manuscript

Abstract

The effect of cadmium (xenobiotic element) and nickel (ultra-trace bioelement) on the adherence to plastic of peripheral polymorphonuclear leukocytes (PMNs) from male (M-PMNs) and female (F-PMNs) donors was analyzed. Exposure of PMNs to either metal stimulated adherence, mainly the early adherence (8 min). A sex influence on the adherence was observed. Up to 45 min of incubation, M-PMNs adhered more than F-PMNs. This sexual dimorphism also took place in the case of metal stimulation. Cadmium and nickel enhanced early spontaneous adherence of cells from either sex, but only the late adherence (25 min) of F-PMNs. The adherence stimulation was generally greater in F-PMNs, but M-PMNs achieved higher adherence levels. Nickel was more effective than cadmium in enhancing the adherence, especially the early adherence of F-PMNs.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Anderson DC, Miller LJ, Schmalstieg FC, Rothlein R, Springer TA (1986) Contributions of the Mac-1 glycoprotein family to adherence-dependent granulocyte functions: Structure-function assessments employing subunit-specific monoclonal antibodies. J Immunol 137:15–27

    Google Scholar 

  • Carlos TM, Harlan JM (1990) Membrane proteins involved in phagocyte adherence to endothelium. Immunol Rev 114:5–28

    Google Scholar 

  • Chettibi S, Lawrence AJ, Stevenson RD (1993) A factor released by monocytes in the presence of dexamethasone stimulates neutrophil locomotion. Br J Pharmacol 108:248–254

    Google Scholar 

  • Chowdhury BA, Chandra RK (1991) Metal compounds and immunotoxicology. In: Merian E (ed) Metals and their compounds in the atmosphere. VCH, Weinheim, pp 605–616

    Google Scholar 

  • Cifone MG, Alesse E, Procopio A, Paolini R, Morrone S, Di Eugenio R, Santoni G, Santoni A (1989) Effects of cadmium on lymphocyte activation. Biochim Biophys Acta 1011:25–32

    Google Scholar 

  • Davis JM, Albert JD, Tracy KJ, Calvano SE, Lowry SF, Shires GT Yurt RW (1991) Increased neutrophil mobilisation and decreased chemotaxis during cortisol and epinephrine infusions. J Trauma 31:725–731

    Google Scholar 

  • Descotes J (1992) Immunotoxicology of cadmium. IARC Sci Publ 118:385–390

    Google Scholar 

  • Eguchi K, Kawakami A, Nakashima M, Ida H, Sakito S, Matsuoka N, Terada K, Sakai M, Kawabe Y, Fukuda T, Ishimaru T, Kurouji K, Fujita N, Aoyagi T, Maeba K, Nagataki S (1992) Interferon-alpha and dexamethasone inhibit adhesion of T-cells to endothelial cells and synovial cells. Clin Exp Immunol 88:448–454

    Google Scholar 

  • Fergusson JE (1990) The toxicity of heavy elements to human beings. The heavy elements: Chemistry, environmental impact and health effects. In: Fergusson JE, Pergamon Press, Oxford, pp 533–568

    Google Scholar 

  • Giordano GF, Lichtman MA (1973) The role of sulfhydryl groups in human neutrophil adhesion, movement and particle ingestion. J Cell Physiol 82:387–396

    Google Scholar 

  • Hernández M, Macia M, Conde JL, de la Fuente M (1991a) Cadmium and nickel modulation of adherence capacity of murine peritoneal macrophages and lymphocytes. Intersexual comparisons. Int J Biochem 23(5/6):541–544

    Google Scholar 

  • Hernández M, Macia M, Cebeira G, de la Fuente M (1991b) Simultaneous effects of nickel and cadmium on the adherence of murine peritoneal macrophages and lymphocytes. Heavy Met Environ Int Conf 1:484–487

    Google Scholar 

  • Hogg N, Bennett R, Cabañas C, Dransfield I (1992) Leukocyte integrin activation. Kidney Int 41:613–616

    Google Scholar 

  • Hoover RL, Briggs RT, Karnovsky MJ (1978) The adhesive interaction between polymorphonuclear leukocytes and endothelial cells in vitro. Cell 14:423–428

    Google Scholar 

  • Horiguchi H, Mukaida N, Okamoto S, Teranishi H, Kasuya M, Matsushima K (1993) Cadmium induces interleukin-8 production in human peripheral blood mononuclear cells with the concomitant generation of superoxide radicals. Lymphokine Cytokine Res 12(6):421–428

    Google Scholar 

  • Jutila MA, Kishimoto TK, Finken M (1991) Low-dose chymotrypsin treatment inhibits neutrophil migration into sites of inflammation in vivo: Effects on Mac-1 and MEL-14 adhesion protein expression and function. Cell Immunol 132:201–214

    Google Scholar 

  • Ley K (1992) Leukocyte adhesion — Molecular basis and physiological consequences. Clin Hemorheol 12:93–108

    Google Scholar 

  • Merian E (ed) (1991) Metals and their compounds in the environment. Occurrence, analysis, and biological relevance. VCH, Weinheim, Germany

    Google Scholar 

  • Otsuka F, Ohsawa M (1991) Differential susceptibility of T- and B-lymphocyte proliferation to cadmium: Relevance to zinc requirement in T-lymphocyte proliferation. Chem Biol Interac 78:193–205

    Google Scholar 

  • Pardi R, Inverardi L, Bender JR (1992) Regulatory mechanisms in leukocyte adhesion: Flexible receptors for sophisticated travelers. Immunol Today 13(6):224–230

    Google Scholar 

  • Pauli BU, Agustin-Voss HG, El-Sabban ME, Johnson RC, Hammer DA (1990) Organ preference of metastasis. The role of endothelial cell adhesion molecules. Cancer Metastasis Rev 9:175–189

    Google Scholar 

  • Rougon G, Durbec P, Figarella-Branger D (1992) Adhesion molecules in cancer. Cancer J 5(3):137–141

    Google Scholar 

  • Schwartz BR, Harlan JM (1989a) Sulfhydryl reducing agents promote neutrophil adherence without increasing surface expression of CD11b/CD18 (Mac-1, Mol). Biochem Biophys Res Commun 165(4):51–57

    Google Scholar 

  • — (1989b) Neutrophil membrane sulfhydryl groups are involved in stimulated neutrophil adherence to endothelium. J Leukocyte Biol 45:177–182

    Google Scholar 

  • Shankar VS, Bax CMR, Bax BE, Alam ASMT, Moonga BS, Simon B, Pazianas M, Huang CL-H, Zaidi M (1993) Activation of the Ca2+ “receptor” on the osteoclast by Ni2+ elicits cytosolic Ca2+ signals: Evidence for receptor activation and inactivation, intracellular Ca2+ redistribution, and divalent cation modulation. J Cell Physiol 155:120–129

    Google Scholar 

  • Sharma RP, Reddy RV (1987) Toxic effects of chemicals on the immune system. In: Haley TJ, Berndt WO (eds) Handbook of toxicology. Hemisphere Pub Co, Washington, pp 555–591

    Google Scholar 

  • Shimizu Y, Newman W, Tanaka Y, Shaw S (1992) Lymphocyte interactions with endothelial cells. Immunol Today 13(3):106–112

    Google Scholar 

  • Silvennoinen-Kassinen S, Ikäheimo I, Karvonen J, Kauppinen M, Kallioinen M (1992) Mononuclear cell subsets in the nickel-allergic reaction in vitro and in vivo. J Allergy Clin Immunol 89(4):794–800

    Google Scholar 

  • Simons SS Jr, Chakraborti PK, Cavanaugh AH (1990) Arsenite and cadmium(II) as probes of glucocorticoid receptor structure and function. J Biol Chem 265(4):1938–1945

    Google Scholar 

  • Smialowicz RJ, Rogers RR, Riddel MM, Stott GA (1984) Immunologic effects of nickel: I. Suppression of cellular and humoral immunity. Environ Res 33:413–427

    CAS  PubMed  Google Scholar 

  • Smith JB, Dwyer SD, Smith L (1989) Cadmium evokes inositol polyphosphate formation and calcium mobilization. J Biol Chem 264(13):7115–7118

    Google Scholar 

  • Smith L, Pijuan V, Zhuang Y, Smith JB (1992) Reversible desensitization of fibroblast to cadmium receptor stimuli: Evidence that growth in high zinc represses a xenobiotic receptor. Exp Cell Res 202:174–182

    Google Scholar 

  • Soukupova D, Dostal M, Piza J (1991) Developmental toxicity of cadmium in mice. II. Immunotoxic effects. Funct Dev Morphol 1(4):31–36

    Google Scholar 

  • Southwick FS, Dabiri GA, Paschetto M, Zigmond SH (1989) Polymorphonuclear leukocyte adherence induces actin polymerization by a transduction pathway which differs from that used by chemoattractants. J Cell Biol 109:1561–1569

    Google Scholar 

  • Speizer LA, Watson MJ, Kanter JR, Brunton LL (1989) Inhibition of phorbol ester binding and protein kinase C activity by heavy metals. J Biol Chem 264(10):5581–5585

    Google Scholar 

  • Suchard SJ, Burton MJ, Dixit VM, Boxer LA (1991) Human neutrophil adherence to thrombospondin occurs through a CD11/CD18-independent mechanism. J Immunol 146(11):3945–3952

    Google Scholar 

  • Sunderman FW Jr, Hopfer SM, Lin S-M, Plowman MC, Stojanovic T, Mong SH-Y, Zaharia O, Ziebka L (1989) Toxicity to alveolar macrophages in rats following parenteral injection of nickel chloride. Toxic Appl Pharmac 100:107–118

    Google Scholar 

  • Wassem M, Bajpai R, Kaw JL (1993) Reaction of pulmonary macrophages exposed to nickel and cadmium in vitro. J Environ Pathol Toxicol Oncol 12(1):47–54

    Google Scholar 

  • Zimmerman GA, Prescott SM, McIntyre M (1992) Endothelial cell interactions with granulocytes: Tethering and signaling molecules. Immunol Today 13(3):93–100

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departamento Biología Animal II, Universidad Complutense de Madrid, 28040, Madrid, Spain

    M. Macia & M. Hernández

Authors
  1. M. Macia
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Hernández
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Macia, M., Hernández, M. Modulation of the adherence of human polymorphonuclear leukocytes by cadmium and nickel: Sexual differences. Arch. Environ. Contam. Toxicol. 29, 15–19 (1995). https://doi.org/10.1007/BF00213080

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00213080

Keywords

Search

Navigation