Abstract
Rats of the RHA/iop and RLA/iop strains have been compared in a conditioned taste aversion procedure using nicotine (0.4 mg/kg SC) as the UCS. The procedure utilised a balanced, within-subject design for assessing discriminative aversions to drug- and saline-paired flavoured solutions. Nicotine produced clear aversions in both strains and there were no detectable differences in acquisition. During extinction, rats of the RHA/iop strain consumed more of the drug-paired flavoured solution than rats of the RLA/iop strain, and this difference became greater as the number of extinction trials proceeded. Differences in total fluid intake were too small to account for these effects that were also shown by changes in proportional intake when both flavoured solutions were presented simultaneously. Aversion was, therefore, rather weaker in RHA/iop rats than in RLA/iop rats. These results suggest that rats of the two strains do not differ in “learning ability” in a general way, and support interpretations based on differences in emotionality.
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Bättig K, Driscoll P, Schlatter J, Uster HJ (1976) Effects of nicotine on the exploratory locomotion patterns of female Roman High- and Low-Avoidance rats. Pharmacol Biochem Behav 4:435–439
Bignami G (1965) Selection for high rates and low rates of avoidance conditioning in the rat. Anim Behav 13:221–227
Broadhurst PL, Bignami G (1965) Correlative effects of psychogenetic selection; a study of the Roman High and Low Avoidance strains of rats. Behav Res Ther 2:273–280
D'Mello GD, Stolerman IP, Booth DA, Pilcher CWT (1977) Factors influencing flavour aversions conditioned with amphetamine in rats. Pharmacol Biochem Behav 7:185–190
D'Mello GD, Goldberg DM, Goldberg SR, Stolerman IP (1981) Conditioned taste aversion and operant behavior in rats: effects of cocaine, apomorphine and some long-acting derivatives. J Pharmacol Exp Ther 219:60–68
Driscoll P (1986) Roman High- and Low-Avoidance rats: present status of the Swiss sublines, RHA/Verh and RLA/Verh, and effects of amphetamine on shuttle-box performance. Behav Genet 16:355–364
Driscoll P, Bättig K (1982) Behavioral, emotional and neurochemical profiles of rats selected for extreme differences in active, two-way avoidance performance. In: Lieblich I (ed) The genetics of the brain. Elsevier, Amsterdam, pp 95–123
Durcan MJ, Fulker DW, Campbell IC (1984a) Differences in the stereotypy response but not the hypomotility response to apomorphine in the Roman High and Low Avoiding strains of rats. Psychopharmacology 82:215–220
Durcan MJ, Wraight KB, Fulker DW (1984b) The current status of two sublines of the Roman high and low avoidance strains. Behav Genet 13:559–569
Durcan MJ, Campbell IC, Chitkara B (1985) Clonidine induced sedation is not altered by stress in the RHA/iop and RLA/iop strains of rats. Psychopharmacology 85:102–105
Garcia J, Ervin FR (1968) Gustatory-visceral and telereceptor-cutaneous conditioning — adaptation in internal and external milieus. Commun Behav Biol Part A 1:389–415
Garg M (1969) Variation in effects of nicotine in four strains of rats. Psychopharmacologia 14:432–438
Gentsch C, Lichtsteiner M, Driscoll P, Feer H (1982) Differential hormonal and physiological responses to stress in Roman high- and low-avoidance rats. Physiol Behav 28:259–263
Kumar R, Pratt JA, Stolerman IP (1983) Characteristics of conditioned taste aversion produced by nicotine in rats. Br J Pharmacol 79:245–253
Marks MJ, Burch JB, Collins AC (1983) Genetics of nicotine response in four inbred strains of mice. J Pharmacol Exp Ther 226:291–302
Martin JR, Baettig K (1980) Acquisition and extinction of gustatory aversion in two lines of rats selectively bred for differential shuttlebox avoidance performance. Behav Proc 5:303–310
Pratt JA, Stolerman IP (1984) Pharmacologically specific pretreatment effects on apomorphine-mediated conditioned taste aversions in rats. Pharmacol Biochem Behav 20:507–511
Satinder KP (1977) Arousal explains difference in avoidance learning of genetically selected rat strains. J Comp Physiol Psychol 91:1326–1336
Winer BJ (1971) Statistical principles in experimental design, 2nd edn. McGraw-Hill, New York
Zeier H, Bättig K, Driscoll P (1978) Acquisition of DRL-20 behavior in male and female Roman high- and low-avoidance rats. Physiol Behav 20:791–793
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Durcan, M.J., Garcha, H.S. & Stolerman, I.P. Conditioned taste aversions produced by nicotine in Roman High and Low Avoidance strains of rats. Psychopharmacology 94, 532–535 (1988). https://doi.org/10.1007/BF00212850
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DOI: https://doi.org/10.1007/BF00212850