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Psychopharmacology

, Volume 94, Issue 4, pp 464–467 | Cite as

Acute alcohol effects on plasma estradiol levels in women

  • Jack H. Mendelson
  • Scott E. Lukas
  • Nancy K. Mello
  • Leslie Amass
  • James Ellingboe
  • Alicja Skupny
Original Investigations

Abstract

Acute administration of alcohol (0.695 g/kg) to healthy adult women resulted in peak blood alcohol levels between 70 and 75 mg/dl within 50–60 min after initiation of drinking. Alcohol induced a significant increase (x=18 pg/ml) in plasma estradiol levels (P<0.01). In contrast, after placebo ingestion, plasma estradiol levels did not change significantly. After alcohol intake, plasma estradiol levels reached peak values at 25 min following initiation of drinking when blood alcohol levels averaged 34 mg/ml. It is postulated that the alcohol-induced increase in plasma estradiol is due to changes in hepatic redox states associated with the catabolism of ethanol.

Key words

Estradiol Alcohol Women 

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Jack H. Mendelson
    • 1
  • Scott E. Lukas
    • 1
  • Nancy K. Mello
    • 1
  • Leslie Amass
    • 1
  • James Ellingboe
    • 1
  • Alicja Skupny
    • 1
  1. 1.Alcohol and Drug Abuse Research CenterHarvard Medical School/McLean HospitalBelmontUSA

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