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Platelet serotonin transport after a single ECT

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Abstract

Platelet 5-HT uptake was examined in six depressed patients before and after a single electroconvulsive treatment and compared with six age- and sex-matched controls. The depressed patients had a significantly (P<0.05) lower V max of platelet 5-HT uptake prior to ECT (22.9±7.6 pm/2×10 platelets) than did control subjects (37.5±9.1 SEM). After a single ECT treatment, the V max significantly (P<0.05) increased to levels (34.6±10.1) no longer significantly different from control. The results are compared with recent data from depressed patients indicating that low baseline levels of platelet imipramine binding increase after ECT treatment.

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Authors and Affiliations

  1. Department of Psychiatry, San Diego VAMC, School of Medicine, University of California, 92093, San Diego, La Jolla, CA, USA

    Jeffrey L. Rausch, Charles L. Rich & S. Craig Risch

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  1. Jeffrey L. Rausch
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  2. Charles L. Rich
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  3. S. Craig Risch
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Rausch, J.L., Rich, C.L. & Risch, S.C. Platelet serotonin transport after a single ECT. Psychopharmacology 95, 139–141 (1988). https://doi.org/10.1007/BF00212783

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  • DOI: https://doi.org/10.1007/BF00212783

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