Abstract
Acute and chronic effects of methsuximide and mephenytoin were examined in pigeons performing under a delayed-matching-to-sample procedure. Acute administrations of methsuximide (25–175 mg/kg) and mephenytoin (40–160 mg/kg) produced generally dose-dependent decreases in accuracy. At the two highest doses, methsuximide decreased rate of responding to the sample stimulus; mephenytoin did so only at the highest dose. At low doses, both methsuximide and mephenytoin increased response rate over control. After 20 sessions of daily exposure to methsuximide (100 mg/kg) or mephenytoin (80 mg/kg), tolerance developed to the accuracy-decreasing effects of both drugs.
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Schlinger, H., Poling, A. Acute and chronic effects of methsuximide and mephenytoin on the delayed-matching-to-sample performance of pigeons. Psychopharmacology 95, 82–86 (1988). https://doi.org/10.1007/BF00212772
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DOI: https://doi.org/10.1007/BF00212772