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Immunological concepts and the eye: A review of the classical and ocular Arthus reactions

Documenta Ophthalmologica volume 64, pages 387–417 (1986)Cite this article

Abstract

Inflammatory processes can involve any tissue in the eye. Despite advances in therapy, the sequelae of inflammation continue to be a major cause of visual impairment. Knowledge of disease pathogenesis in clinical ocular inflammations remains imprecise, and defined models are crucial in developing this understanding and evolving rational approaches to treatment. This review analyzes the contributions that studies of the classical and Arthus ocular Arthus-type reactions have made as to how the eye functions as an immunological entity. The anticipated development of therapeutic agents that may modulate immune processes with remarkable specificity, gives a new impetus to such experimental studies.

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References

  1. Cochrane GC, Janoff A (1974) The Arthus reaction: a model of neutrophil and complement-mediated injury. In: Zweifach BW, Grant L, McCluskey RT (eds) The Inflammatory Process, Vol 3, New York, Academic Press, 2, pp 85–162

    Google Scholar 

  2. Coombs RRA, Gell PGH (1975) Classification of allergic reactions responsible for clinical hypersensitivity and disease. In Gell PGH, Coombs RRA, Lachmann PJJ (eds) Clinical Aspects of Immunology, Oxford, Blackwell, ed 3, pp 761–781

    Google Scholar 

  3. Foss B (1949) Experimental anaphylactic iridocyclitis. Acta Pathol Microbiol Scand 81 Suppl: 1–128

    Google Scholar 

  4. Breebaart AC (1960) Experimental corneal anaphylaxis. Amsterdam, Drukkerij Hollandia

    Google Scholar 

  5. Woods AC (1961) Endogenous inflammations of the uveal tract. Baltimore, Williams and Wilkins

    Google Scholar 

  6. Leira H (1965) Studies on causal relations in endogenous, non-purulent, ocular inflammations. Acta Ophthalmol 85 Suppl: 1–201

    Google Scholar 

  7. Arthus MM (1903) Repeated injections of horse serum into the rabbit. CR Soc Biol (Paris) 55: 817–820

    Google Scholar 

  8. Arthus MM, Breton M (1903) Cutaneous lesions from the injection of horse serum into the rabbit sensitized to this serum. CR Soc Biol (Paris) 55: 1478–1480

    Google Scholar 

  9. Opie EL (1924) Inflammatory reaction of the immune animal to antigen (Arthus phenomenon) and its relation to antibodies. J Immunol 9: 231–245

    Google Scholar 

  10. Opie EL (1924) Desensitization to local action of antigen (Arthus phenomenon). J Immunol 9: 277–253

    Google Scholar 

  11. Opie EL (1924) Acute inflammation caused by antibody in an animal previously treated with antigen. The relation of antigen to antibody in the Arthus phenomenon. J Immunol 9: 255–257

    Google Scholar 

  12. Opie EL (1924) Pathogenesis of the specific inflammatory reaction of immunized animals (Arthus phenomenon). The relation of local ‘sensitization’ to immunity. J Immunol 9: 259–268

    Google Scholar 

  13. Tanabe S, Yonemasu K, Ochi T (1976) Development of two inbred strains of rats and characteristics of their skin reactions. Biken J 19: 151–158

    Google Scholar 

  14. Graham RC, Griffin R (1972) Arthus synovitis with horseradish peroxidase as antigen: sequential participation of platelets and leucocytes. Br J Exp Pathol 53: 578–585

    Google Scholar 

  15. Movat HZ, Fernando NVP (1963) Allergic inflammation I. The earliest fine structure changes at the blood-tissue barrier during antigen-antibody interaction. Am J Pathol 42: 41–59

    Google Scholar 

  16. Sabesin SM, Banfield WG (1961) Electron microscopy of the Arthus reaction, using ferritin as antigen. Proc Soc Exp Biol Med 107: 546–550

    Google Scholar 

  17. Cochrane CG, Weigle WO (1958) The cutaneous reaction to soluble antigen-antibody complexes: a comparison with the Arthus phenomenon. J Exp Med 108: 591–604

    Google Scholar 

  18. Oort J, van Rijssel TA (1961) Fluorescent protein tracer studies in allergic reactions. I. The fate of fluorescent antigen in active and passive Arthus reaction in the guinea-pig skin. Immunology 4: 329–336

    Google Scholar 

  19. Cannon PR, Marshall CE (1941) Studies on the mechanism of the Arthus phenomenon. J Immunol 40: 127–146

    Google Scholar 

  20. Fischel EE, Kabat EA (1947) A quantitative study of the Arthus phenomenon induced passively in the rabbit. J Immunol 55: 337–343

    Google Scholar 

  21. Förster O, Stoklaska E (1966) Quantitative studies on the Arthus reaction in rats. Med Pharmacol Exp 14: 37–44

    Google Scholar 

  22. Weigle WO, Maurer PH (1957) The effect of complements on soluble antigen-antibody complexes. J Immunol 79: 211–222

    Google Scholar 

  23. Maillard JL, Voisin GA (1973) Non-haemorrhagic Arthus reaction and its independence from circulating antibodies and complement. Int Arch Allergy Appl Immunol 45: 190–192

    Google Scholar 

  24. Sandberg AL, Osler AG, Shin HS, Oliveira BH (1970) The biologic activities of guinea pig antibodies. II. Modes of complement interaction with gamma-1 and gamma-2 immunoglobulins. J Immunol 104: 329–334

    Google Scholar 

  25. Cochrane CG, Weigle WO, Dixon FJ (1959) The role of polymorphonuclear leukocytes in the initiation and cessation of the Arthus vasculitis. J Exp Med 110: 481–494

    Google Scholar 

  26. Grant L, Ross MH, Moses J, Prose P, Zweifach BW, Ebert RH (1967) The extravascular nature of Arthus reactions elicited by ferritin. A combined light and electron microscopic analysis of immune states in rabbit ear chambers and mesenteries. ZA Zellforsch Microsk Anat (Histochem) 77: 554–588

    Google Scholar 

  27. Margaretten W, Howes EL, McKay DG (1975) The effect of shock on the inflammatory response. A reevaluation of the role of platelets in the active Arthus reaction. Am J Pathol 78: 159–170

    Google Scholar 

  28. Gitlin D, Gross PAM, Janeway CA (1959) The gamma globulins and their clinical significance. I. Chemistry, immunology and metabolism. N Engl J Med 260: 21–27

    Google Scholar 

  29. Alper CA, Rosen FS, Watson L (1967) Studies of the in vivo behaviour of human C'3 in normal subjects and patients. J Clin Invest 46: 2021–2034

    Google Scholar 

  30. Uriuhara T, Movat HZ (1964) Allergic inflammation. IV. The vascular changes during the development and progression of the direct active and passive Arthur reactions. Lab Invest 13: 1057–1079

    Google Scholar 

  31. Venkatachalam MA, Cotran RS (1970) Ultrastructure of the local Arthus phenomenon using horseradish peroxidase as antigen. Lab Invest 23: 129–135

    Google Scholar 

  32. Ward PA (1968) Chemotaxis of mononuclear cells. J Exp Med 128: 1201–1221

    Google Scholar 

  33. Ramsey WS, Grant L (1974) Chemotaxis. In Zweifach BW, Grant L, McCluskey RT (eds) The Inflammatory Process. Vol. 1 New York, Academic Press, ed 2, pp 287–362

    Google Scholar 

  34. Germuth FG, Maumenee AE, Senterfit LB, Pollack AD (1962) Immunohistologic studies on antigen-antibody reactions in the avascular cornea. I. Reactions in rabbits actively sensitized to foreign protein. J Exp Med 115: 929–928

    Google Scholar 

  35. Humphrey JH, White RG (1970) Immunology for students of medicine. Oxford, Blackwell, p 453

    Google Scholar 

  36. Siqueira M, Passos HC, Bier OG (1967) Inhibitory effect of large doses of histamine on the passive Arthus reaction. Int Arch Allergy Appl Immunol 31: 117–122

    Google Scholar 

  37. Takahashi M, Takahashi S, Brade V, Nussenzweig V (1978) Requirements for the solubilization of immune aggregates by complement: the role of the classical pathway. J Clin Invest 62: 349–358

    Google Scholar 

  38. Voisin GA, Maillard J (1967) Studies of hypersensitivity III. A quantitative study of the laws governing the increase of vascular permeability in the Arthus reaction in the guinea pig. Rev Fr Etud Clin Biol 12: 865–877

    Google Scholar 

  39. Cochrane CG, Müller-Eberhard HJ, Aikin BS (1970) Depletion of plasma complement in vivo by a protein of cobra venom: its effect on various immunologic reactions. J Immunol 105: 55–69

    Google Scholar 

  40. DeShazo CV, McGrade MT, Henson PM, Cochrane CG (1972) The effect of complement depletion on neutrophil migration in acute immunologic arthritis. J Immunol 108: 1414–1419

    Google Scholar 

  41. Jensen JA, Garces MC, Iglesias E (1971) Specific inactivation of the fourth complement component. 1. In vivo studies. Infect Immun 4: 12–19

    Google Scholar 

  42. Maillard JL, Zarco RM (1868) Complement depletion by a factor extracted from cobra venom. Effect on several immune reactions in the guinea pig and rat. Ann Inst Pasteur (Paris) 114: 756–774

    Google Scholar 

  43. Ward PA, Cochrane CG (1965) Bound complement and immunologic injury of blood vessels. J Exp Med 121: 215–233

    Google Scholar 

  44. Yamamoto S, Dunn CJ, Deporter DA, Capasso F, Willoughby DA, Huskisson EC (1975) A model for the quantitative study of Arthus (immunologic) hypersensitivity in rats. Agents Actions 5: 374–377

    Google Scholar 

  45. Lewis E, Turk JL (1975) Comparison of the effect of various antisera and cobra venom factor on inflammatory reactions in guinea pig skin II. The Arthus reaction and the local Schwartzman reaction. J Pathol 115: 111–125

    Google Scholar 

  46. Osier A (1976) Complement. Mechanisms and functions. New Jersey, Prentice-Hall

    Google Scholar 

  47. Yamamoto S, Yoshinaga M, Hayashi H (1971) The natural mediator for PMN emigration in inflammation. II. Common antigenicity of leucoegresin with immunoglobulin G. Immunology 20: 803–808

    Google Scholar 

  48. Yoshinaga M, Yamamoto S, Maeda S, Hayashi H (1971) The natural mediator for PMN emigration in inflammation. III. In vitro production of a chemotactic factor by inflammatory SH-dependent protease from serum immunoglobulin G. Immunology 20: 809–815

    Google Scholar 

  49. Cochrane CG, Unanu ER, Dixon FJ (1965) A role of polymorphonuclear leukocytes and complement in nephrotoxic nephritis. J Exp Med 122: 99–116

    Google Scholar 

  50. Humphrey JH (1955) The mechanism of Arthus reactions. I. The role of polymorphonuclear leucocytes and other factors in reversed passive Arthus reactions in rabbits. Br J Exp Pathol 36: 268–282

    Google Scholar 

  51. DeShazo CV, Henson PM, Cochrane CG (1972) Acute immunologic arthritis in rabbits. J Clin Invest 51: 50–57

    Google Scholar 

  52. Ellman L, Green I, Judge F, Frank MM (1971) In vivo studies in C4 deficient guinea pigs. J Exp Med 134: 162–175

    Google Scholar 

  53. Maillard JL, Voisin GA (1969) Elicitation of Arthus reactions in guinea pigs by homologous gamma-1 and gamma-2 immunoglobulins. Proc Soc Exp Biol Med 133: 1188–1194

    Google Scholar 

  54. Henson PM, Cochrane CG (1969) Immunological induction of increased vascular permeability. II. Two mechanisms of histamine release from rabbit platelets involving complement. J Exp Med 129: 167–184

    Google Scholar 

  55. Siqueira M, Nelson RA (1961) Platelet agglutination by immune complexes and its possible role in hypersensitivity. J Immunol 86: 516–525

    Google Scholar 

  56. Udaka K (1971) The Arthus reaction. In: Movat HZ (ed) Inflammation, Immunity and Hypersensitivity. New York, Harper and Row, pp 390–423

    Google Scholar 

  57. Henson PM, Cochrane CG (1971) Acute immune complex disease in rabbits. The role of complement and of a leukocyte-dependent release of vasoactive amines from platelets. J Exp Med 133: 554–571

    Google Scholar 

  58. Kravis TC, Henson PM (1977) Accumulation of platelets at sites of antigen-antibody-mediated injury: a possible role for IgE antibody and mast cells. J Immunol 118: 1569–1573

    Google Scholar 

  59. Stetson CA (1951) Similarities in the mechanisms determining the Arthus and Schwartzman phenomenon. J Exp Med 94: 347–358

    Google Scholar 

  60. Nachman RL, Weksler B, Ferris B (1970) Increased vascular permeability produced by human platelet granule cationic extract. J Clin Invest 49: 274–281

    Google Scholar 

  61. Humphrey JH (1955) The mechanism of Arthus reactions. II. The role of polymorphonuclear leucocytes and platelets in reversed passive reactions in the guinea pig. Br J Exp Pathol 36: 283–289

    Google Scholar 

  62. Bier OG, Passos HC, Siqueira M (1968) Haemorrhagic reactions elicited at sites of passive cutaneous anaphylaxis by the intravenous injection of aggregated gamma-globulin. Immunology 14: 291–298

    Google Scholar 

  63. Parish WE, Pepys J (1968) The lung in allergic disease. In: Gell PGH, Coombs RRA (eds) Clinical Aspects of Immunology. Oxford, Blackwell, pp 959–996

    Google Scholar 

  64. Humphrey JH, Jaques R (1954) The histamine and serotonin content of the platelets and polymorphonuclear leucocytes of various species. J Physiol 124: 305–310

    Google Scholar 

  65. Förster O, Stoklaska E (1967) The combined role of histamine and 5-hydroxytryptamine in the passive Arthus reaction in the rat. Z Immunitatsforsch Immunobiol 133: 68–79

    Google Scholar 

  66. Gell PGH, Hinde IT (1954) Observation on the histology of the Arthus reaction and its reaction to other known types of skin hypersensitivity. Int Arch Appl Immunol 5: 23–46

    Google Scholar 

  67. Sabesin SM, Banfield WG (1963) Electron microscopy of hypersensitivity reactions: the Arthus phenomenon. Am J Pathol 42: 551–570

    Google Scholar 

  68. Salvin SB (1958) Occurrence of delayed hypersensitivity during the development of Arthus type hypersensitivity. J Exp Med 107: 109–124

    Google Scholar 

  69. Shirasawa H (1967) The electron microscopic morphology of allergic-hypersensitivity reactions in the cornea of rabbits and guinea pigs. I. The Arthus phenomenon of the cornea. Frankf Z Pathol 76: 270–305

    Google Scholar 

  70. Silverstein AM (1964) Ectopic antibody formation in the eye. Pathologic implications. In: Maumenee AE, Silverstein AM (eds) Immunopathology of uveitis. Baltimore, Williams and Wilkins, pp 83–97

    Google Scholar 

  71. Smelser GK, Pei YF (1965) Observations on the effect of steroids on experimental uveitis. An analysis of the mode of action of dexamethasone and fluorometholone on ferritin-induced uveitis in rabbits. Invest Ophthalmol Res 4: 249–263

    Google Scholar 

  72. Gnad HD, Schimmelpfennig B, Witmer R (1973) Observations on the effect of steroids on experimental uveitis. An analysis of the mode of action of dexamethasone and fluorometholone on ferritin-induced uveitis in rabbits. Ophthalmic Res 5: 204–214

    Google Scholar 

  73. Pederson JE (1982) Fluid permeability of monkey ciliary epithelium in vivo. Invest Ophthalmol Vis Sci 23: 176–180

    Google Scholar 

  74. Carmichael LE, Medic BLS, Bistner SI, Aguirre GD (1975) Viral-antibody complexes in canine adenovirus type 1 (CAV-1) ocular lesions: Leukocyte chemotaxis and enzyme release. Cornell Vet 65: 331–351

    Google Scholar 

  75. Benacerraf B, Kabat EA (1950) A quantitative study of the Arthus phenomenon induced passively in the guinea pig. J Immunol 64: 1–19

    Google Scholar 

  76. Issekutz AC (1983) Comparison of the effects of glucocorticoid and indomethacin treatment on the acute inflammatory reaction in rabbits. Immunopharmacology 5: 183–195

    Google Scholar 

  77. Kuhns WJK (1953) Immunochemical studies of antitoxin produced in normal and allergic individuals hyperimmunized with diphtheria toxoid. III. Studies of the passive Arthus reaction in guinea pigs using human precipitating and non-precipitating diphtheria antitoxin. J Exp Med 77: 903–910

    Google Scholar 

  78. Ishizaka K, Ishizaka T, Sugahara T (1961) Biological activity of aggregated gamma-globulin. III. Production of Arthus-like reactions. J Immunol 86: 220–227

    Google Scholar 

  79. Raffel S, Arnaud LE, Dukes CD, Huang JS (1949) The rôle of the ‘wax’ of the tubercle bacillus in establishing delayed hypersensitivity. II. Hypersensitivity to a protein antigen, egg albumin. J Exp Med 90: 53–72

    Google Scholar 

  80. Rich AR, Follis RH (1940) Studies on the site of hypersensitivity in the Arthus phenomenon. Bull Johns Hopkins Hosp 66: 106–122

    Google Scholar 

  81. Allansmith MR, McClellan BH (1975) Immunoglobulins in the human cornea. Am J Ophthalmol 80: 123–132

    Google Scholar 

  82. Stock EL, Aronson SB (1970) Corneal immune globulin distribution. Arch Ophthalmol 84: 355–359

    Google Scholar 

  83. Hedbys BO, Mishima S, Maurice DM (1963) The inhibition pressure of the corneal stroma. Exp Eye Res 2: 99–111

    Google Scholar 

  84. Maurice DM, Watson PG (1965) The distribution and movement of serum albumin in the cornea. Exp Eye Res 4: 355–365

    Google Scholar 

  85. Sery TW, Pinkes AH, Nagy RM (1962) Immune corneal rings. II. Diffusion kinetics of equine albumin in the rabbit cornea. Invest Ophthalmol 1: 756–761

    Google Scholar 

  86. Mondino BJ, Ratajczak HV, Goldberg DB, Schanzlin DJ, Brown SI (1980) Alternate and classical pathway components of complement in the normal cornea. Arch Ophthalmol 98: 346–349

    Google Scholar 

  87. Maurice DM (1957) The structure and transparency of the cornea. J Physiol 136: 263–286

    Google Scholar 

  88. Allansmith MR, de Ramus A, Maurice DM (1979) The dynamics of IgG in the cornea. Invest Ophthalmol Vis Sci 18: 947–955

    Google Scholar 

  89. Yamagami I (1971) Electron-microscopic study of the cornea. II. Electron-microscopic observation of Arthus phenomenon in the cornea. Jpn J Ophthalmol 15: 192–203

    Google Scholar 

  90. Felberg NT, Sery TW (1978) The reverse Wessely phenomenon: immune corneal rings following systemic immunisation. Br J Ophthalmol 62: 831–835

    Google Scholar 

  91. Howes EL (1970) Cellular hypersensitivity in the cornea: an analysis of the limbus and limbal cellular infiltration by light and electron microscopy. Arch Ophthalmol 83: 475–488

    Google Scholar 

  92. Leibowitz HM, Elliott JH (1965) Antibody production in corneal hypersensitivity. Arch Ophthalmol 73: 687–695

    Google Scholar 

  93. Leibowitz HM, Parks JJ, Maumenee AE (1962) Manifestations of localized hypersensitivity in a previously sensitized tissue. Arch Ophthalmol 68: 66–71

    Google Scholar 

  94. Parks JJ, Leibowitz HM, Maumenee AE (1962) A transient stage of suspected delayed hypersensitivity during the early induction phase of immediate corneal sensitivity. J Exp Med 115: 867–880

    Google Scholar 

  95. Remky H (1967) Prevention of the Wessely phenomenon by antigen excess. Bull Mem Soc Fr Ophthalmol 80: 63–68

    Google Scholar 

  96. Shikano S (1958) The Arthus phenomenon in the cornea. Jpn J Ophthalmol 2: 166–172

    Google Scholar 

  97. Jordano J, Sandoval E (1973) Corneal stromal lesions of immunological origin studied by light and electron microscopy. Arch Soc Esp Oftalmol 33: 307–328

    Google Scholar 

  98. Sery TW, Pinkes AH, Nagy RM (1962) Immune corneal rings. I. Evaluation of reactions to equine albumin. Invest Ophthalmol 1: 672–685

    Google Scholar 

  99. Friedlaender MH, Dvorak HF (1977) Morphology of delayed-type hypersensitivy reactions in the guinea pig cornea. J. Immunol 118: 1558–1563

    Google Scholar 

  100. Mayerson HS, Wolfran CG, Shirley HH, Wasserman K (1960) Regional differences in capillary permeability. Am J Physiol 198: 155–160

    Google Scholar 

  101. Oeff I (1960) Kinetics of the exchange of plasma proteins between blood and body cavities. In: Peeters H (ed) Protides of Biological Fluids: proceedings of the Seventh Colloquium. Amsterdam, Elsevier, pp 164–170

    Google Scholar 

  102. Bill A (1968) A method to determine osmotically effective albumin and gammaglobulin concentrations in tissue fluids. Its application to the uvea and a note on the effects of capillary ‘leaks’ on tissue fluid dynamics. Acta Physiol Scand 73: 511–522

    Google Scholar 

  103. Pedersen OØ, Tønjum AM (1975) Protein diffusion barriers in the anterior uvea of the rabbit eye. Acta Ophthalmol 53: 67–76

    Google Scholar 

  104. Raviola G (1977) The structural basis of the blood-ocular barriers. In: Bito LZ, Davson H, Fenstermacher JD (eds) The Ocular and Cerebrospinal Fluids. London, Academic Press, pp 27–63

    Google Scholar 

  105. Shabo AL, Maxwell DS (1972) The blood-aqueous barrier to tracer protein: A light and electron microscopic study of the primate ciliary process. Microvasc Res 4: 142–158

    Google Scholar 

  106. Hultsch E (1979) The vitreous structure and ocular inflammation. In: Silverstein AM, O'Connor GR (eds) Immunology and Immunopathology of the Eye. New York, Masson USA, pp 97–102

    Google Scholar 

  107. Maren TH (1974) The cerebrospinal fluid, with notes on aqueous humor and endolymph. In: Mountcastle B (ed) Medical Physiology. St. Louis, Mosby, Vol 2, pp 1116–1136

    Google Scholar 

  108. Weber K, Ueki H, Braun-Falco O (1973) Immunopathology of the passive Arthus reaction using horseradish peroxidase as antigen. Virchows Archiv (Cell Pathol) 14: 379–383

    Google Scholar 

  109. Peress NS, Miller F, Palu W (1977) The immunopathophysiological effects of chronic serum sickness on rat choroid plexus, ciliary process and renal glomeruli. J Neuropathol Exp Neurol 36: 726–733

    Google Scholar 

  110. Raviola G, Raviola E (1978) Intercellular junctions in the ciliary epithelium. Invest Ophthalmol Vis Sci 17: 958–981

    Google Scholar 

  111. Peress NS, Roxburgh VA, Gelfand MC (1982) Binding sites for immunoglobulin G in rabbit ciliary processes. Invest Ophthalmol Vis Sci 23: 457–463

    Google Scholar 

  112. Peress NS, Tompkins DC (1982) Pericapillary permeability of the ciliary processes: role of molecular charge. Invest Ophthalmol Vis Sci 23: 168–175

    Google Scholar 

  113. Hirsch M, Renard G, Faure J-P, Pouliquen Y (1978) Endothelial cell junctions in the ciliary body microvasculature: a freeze-fracture study in the rabbit. Graefes Arch Klin Exp Ophthalmol 208: 69–76

    Google Scholar 

  114. Fernando AN (1960) Immunological studies with l131 labeled antigen in experimental uveitis. Arch Ophthalmol 63: 515–539

    Google Scholar 

  115. Inoue Y, Nomura T, Kodama Y (1976) Vascular permeability in experimental immunologic retinal vasculitis. Acta Soc Ophthalmol Jpn 80: 658–666

    Google Scholar 

  116. Segawa K, Smelser GK (1969) Electron microscopy of experimental uveitis. Invest Ophthalmol 8: 497–520

    Google Scholar 

  117. Howes EL, McKay DG (1975) Comparison of the ocular effects of circulating endotoxin and immune complexes: Role of vasoactive amines. J Immunol 114: 734–737

    Google Scholar 

  118. Howes EL, McKay DG (1975) Circulating immune complexes: effects on ocular vascular permeability in the rabbit. Arch Ophthalmol 93: 365–370

    Google Scholar 

  119. Peress NS, Tompkins DC (1977) The ciliary process in experimental chronic serum sickness. J Neuropathol Appl Neurol 36: 622

    Google Scholar 

  120. Howes EL, McKay DG, Aronson SB (1971) An ultrastructural study of the ciliary process in the rabbit following systemic administration of bacterial endotoxin. Lab Invest 24: 217–228

    Google Scholar 

  121. Bartels SP, Pederson JE, Gaasterland DE, Armaly MF (1979) Sites of breakdown of the blood-aqueous barrier after paracentesis of the rhesus monkey eye. Invest Ophthalmol Vis Sci 18: 1050–1060

    Google Scholar 

  122. Kozart DM (1968) Light and electron microscopic study of regional morphologic differences in the processes of the ciliary body in the rabbit. Invest Ophthalmol 7: 15–33

    Google Scholar 

  123. Pappas GD, Tennyson VM (1962) An electron microscopic study of the passage of colloidal particles from the blood vessels of the ciliary processes and choroid plexus of the rabbit. J Cell Biol 15: 227–238

    Google Scholar 

  124. Meyers RL, Shabo AL, Maxwell DS (1975) Effect of prostaglandin on the blood aqueous barrier in the rabbit ciliary process. Prostaglandins 9: 167–173

    Google Scholar 

  125. Pedersen OØ (1975) Electron microscopic studies on the blood-aqueous barrier of prostaglandin-treated rabbit eyes. I. Iridial and ciliary processes. Acta Ophthalmol 53: 685–698

    Google Scholar 

  126. Pedersen OØ, Aursnes I (1978) Electron microscopy of the ciliary epithelium in thrombocytopenic rabbits. Acta Ophthalmol 56: 865–875

    Google Scholar 

  127. Levene RZ, Breinin GM (1959) Ocular effects of endotoxin. Arch Ophthalmol 61: 568–577

    Google Scholar 

  128. Von Sallman L, Dillon B (1947) The effect of di-isopropyl fluorophosphate on the capillaries of the anterior segment of the eye in rabbits. Am J Ophthalmol 30: 1244–1262

    Google Scholar 

  129. Wegner K (1967) Regional differences in ultrastructure of the rabbit ciliary processes: The effect of anaesthetics and fixation procedures. Invest Ophthalmol 6: 177–191

    Google Scholar 

  130. Ormerod LD (1977) Quantitative and qualitative studies of an immune-complex uveitis. MSc thesis. Birmingham University, UK

    Google Scholar 

  131. Shimada K (1970) The complement components and their inactivators in the intraocular fluids of the guinea pig. Invest Ophthalmol 9: 307–315

    Google Scholar 

  132. Mondino BJ, Rao H (1983) Hemolytic complement activity in aqueous humor. Arch Ophthalmol 101: 465–468

    Google Scholar 

  133. Mondino BJU, Rao H (1983) Complement levels in normal and inflamed aqueous humor. Invest Ophthalmol Vis Sci 24: 380–384

    Google Scholar 

  134. François J, Victoria-Troncoso V, Maudgal PC (1976) Immunology of the vitreous body. Mod Probl Ophthalmol 16: 196–207

    Google Scholar 

  135. Barker SA, Crews SJ, Marsters JB, Stacey M (1965) Fingerprinting the hyaluronic acid-protein complex of human vitreous humour. Clin Chim Acta 11: 139–145

    Google Scholar 

  136. Maurice DM (1959) Protein dynamics in the eye studied with labelled proteins. Am J Ophthalmol 47: 361–367

    Google Scholar 

  137. Ridley A, Rainbird S (1978) An immunofluorescence study of the passive Arthus reaction in rat sciatic nerve. Neuropathol Appl Neurobiol 4: 225–234

    Google Scholar 

  138. Davidoff LM, Seegal BC, Seegal D (1932) The Arthus phenomenon: local anaphylactic inflammation in the rabbit brain. J Exp Med 55: 163–168

    Google Scholar 

  139. Sery TW, Nagy RM, Barber GW (1971) Corneal hypersensitivity. I. Escape kinetics of antigen from sensitized corneas. J Immunol 106: 217–225

    Google Scholar 

  140. Smolin G, Hall JM (1973) Afferent arc of the corneal immunologic reaction. II. Local and systemic response to bovine gamma-globulin. Arch Ophthalmol 90: 231–234

    Google Scholar 

  141. Parks JJ, Leibowitz HMI, Maumenee AE (1961) The effect of route of inoculation upon development of antibody in rabbits. J Immunol 87: 199–204

    Google Scholar 

  142. Schwab F (1959) Antibody formation (precipitin) in the cornea in response to the simultaneous injection of different antigens. A study concerning local antibody production in the cornea. Graefes Arch Klin Exp Ophthalmol 160: 592–627

    Google Scholar 

  143. Breebaart AC, James-Witte J (1959) Studies on experimental corneal allergy. Am J Ophthalmol 48: 37–47

    Google Scholar 

  144. Germuth FG, Maumenee AE, Pratt-Johnson J, Senterfit LOB, Van Arnam CE, Pollack AD (1958) Observations on the site and mechanism of antigen-antibody interaction in anaphylactic hypersensitivity. Am J Ophthalmol 46 (Suppl): 282–287

    Google Scholar 

  145. Morawiecki von J (1956) Precipitation in the living cornea during antigen-antibody reactions. Ophthalmologica 132: 236–243

    Google Scholar 

  146. Nelken E, Michaelson IC, Nelken D, Gurevitch J (1960) Experimental corneal allergy: correlation between clinical and serologic findings. Am J Ophthalmol 50: 583–586

    Google Scholar 

  147. Parks JJ, Leibowitz HMI, Maumenee AE (1962) Immediate hypersensitivity reactions in the cornea of the guinea pig. J Immunol 89: 323–325

    Google Scholar 

  148. Parunovic A (1971) Experimental marginal corneal infiltrates. Br J Ophthalmol 55: 481–483

    Google Scholar 

  149. Leibowitz HM, Parks JJ (1963) The in vitro production of antibody by delayed phase corneal limbal foci. J Exp Med 117: 197–211

    Google Scholar 

  150. Mimura Y, Hohki T, Furukawa J, Ikeda F, Tsumure R (1968) Antibody formation after intracorneal sensitization. Acta Soc Ophthalmol Jpn 72: 994–997

    Google Scholar 

  151. Shukla BR, Gupta NC, Ahuja OP (1972) Corneal immune reactions. Ind J Ophthalmol 20: 84–87

    Google Scholar 

  152. Thompson R, Gallardo E, Khorazo D (1936) Precipitatins in the ocular tissues of rabbits generally and locally immunized with crystalline egg albumin. Am J Ophthalmol 19: 852–858

    Google Scholar 

  153. Thompson R, Harrison VM (1954) Factors affecting antibody production in the rabbit's cornea. Fed Proc 13: 515–516

    Google Scholar 

  154. Thompson R, Olson VH (1950) Antibody production in the rabbit's cornea. J Immunol 65: 633–651

    Google Scholar 

  155. Thompson R, Olson VH, Sibal LR (1957) Conditions for the demonstration of local peripheral antibody formation and failure to show localization of antibody by antigen. J Immunol 79: 508–515

    Google Scholar 

  156. Elliott JH, Flax MH, Leibowitz HM (1966) The limbal cellular infiltrate in experimental corneal hypersensitivity. I. Morphologic studies after primary sensitization. Arch Ophthalmol 76: 104–116

    Google Scholar 

  157. Davanger M, Pedersen OØ (1978) The ciliary body and the iris in experimental uveitis in rabbits: A scanning electron microscopic study. Acta Ophthalmol 56: 857–864

    Google Scholar 

  158. Keckarovski A (1958) A contribution to the experimental study of the allergic processes of the anterior segment of the eye. Br J Ophthalmol 42: 288–295

    Google Scholar 

  159. Tremaine MM (1957) Corneal reactions to horse serum in rabbits passively sensitized by leukocytes. J Immunol 79: 467–479

    Google Scholar 

  160. Bito LZ (1977) Inflammatory effects of endotoxin-like contaminants in commonly used protein preparations. Science 196: 83–85

    Google Scholar 

  161. Dolezel J, Strauss H, Bienenstock J (1971) Antigen in feed as cause of antibody in unimmunized animals. Int Arch Allergy Appl Immunol 40: 749–753

    Google Scholar 

  162. Greene MI, Campbell RD, Millin JA, Foster CS (1984) Suppression of delayed hypersensitivity after corneal inoculation with HSV-1. Invest Ophthalmol Vis Sci 25 (Suppl): 116

    Google Scholar 

  163. Wessely K (1911) Experimental anaphylactic reactions in the cornea. Munch Med Wschr 58: 1713–1714

    Google Scholar 

  164. Sery TW, Nagy RM (1962) Immune corneal rings. III. Mechanism of local immune corneal ring formation. Invest Ophthalmol 1: 762–772

    Google Scholar 

  165. Hall JM, Pribnow JF (1983) An ELISA test to detect IgG antibody production by rabbit ocular cells. Curr Eye Res 2: 459–463

    Google Scholar 

  166. Hogan MJ, Diaz-Bonnet V, Okumoto M, Kimura SJ (1962) Experimental staphylococcic keratitis. Invest Ophthalmol 1: 267–272

    Google Scholar 

  167. Leskowitz S, Waksman BH (1960) Studies in immunization. I. The effect of route of injection of bovine serum albumin in Freund adjuvant on production of circulating antibody and delayed hypersensitivity. J Immunol 84: 58–72

    Google Scholar 

  168. Negoro Y (1961) Studies on antibody formation in the cornea by means of fluorescein and 131l-labelled protein. Acta Soc Ophthalmol Jpn 65: 956–974

    Google Scholar 

  169. Salvin SB, Gregg MB (1961) The specificity of allergic reactions. IV. The cornea. Proc Soc Exp Biol Med 107: 478–483

    Google Scholar 

  170. Valdes AJ, Germuth FG (1978) Effect of cortisone upon vascular permeability to antibody. Lab Invest 39: 66–69

    Google Scholar 

  171. Dvorak HF, Dvorak AM (1974) Cutaneous basophil hypersensitivity. In: Brent L, Holborow J (eds) Progress in Immunology II, Vol 3, Biological Aspects II, Amsterdam, North-Holland, pp 171–181

    Google Scholar 

  172. Sery TW, Nagy RM (1971) Corneal hypersensitivity. II. Specific binding of antigen in sensitized corneas. J Immunol 106: 226–232

    Google Scholar 

  173. Aronson SB, Goodner EK, Yamamoto E, Foreman M (1965) Mechanisms of the host response in the eye. I. Changes in the anterior eye following immunization to a heterologous antigen. Arch Ophthalmol 73: 402–412

    Google Scholar 

  174. Aronson SB, Martenet AC, Yamamoto EA, Bedford MJ (1966) Mechanisms of the host response in the eye. II. Variations in ocular disease produced by several different antigens. Arch Ophthalmol 76: 266–273

    Google Scholar 

  175. Davis PL, Watson JI, Sapp GA (1970) Experimental phlyctenular keratitis. Can J Ophthalmol 5: 284–292

    Google Scholar 

  176. Mohos SC, Wagner BM (1969) Damage to collagen in corneal immune injury. Arch Pathol 88: 3–20

    Google Scholar 

  177. Mondino BJ, Kowalski RP (1982) Phlyctenulae and catarrhal infiltrates. Occurrence in rabbits immunized with staphylococcal cell walls. Arch Ophthalmol 100: 1968–1971

    Google Scholar 

  178. Mondino BJ, Kowalski RP, Ratajczak HV, Peters J, Cutler SB, Brown SI (1981) Rabbit model of phlyctenulosis and catarrhal infiltrates. Arch Ophthalmol 99: 891–895

    Google Scholar 

  179. Davis PL, Watson JI (1969) Experimental conjunctival phlyctenulosis. Can J Ophthalmol 4: 183–190

    Google Scholar 

  180. Waksman BH, Bullington SJ (1956) A quantitative study of the passive Arthus reaction in the rabbit eye. J Immunol 76: 441–453

    Google Scholar 

  181. Koss MN, Chernack WJ, Griswold WR, McIntosh RM (1973) The choroid plexus in acute serum sickness. Morphologic, ultrastructural, and immunohistologic studies. Arch Pathol 96: 331–334

    Google Scholar 

  182. Rahi AHS, Tripathi RC (1976) Anatomy of passive Arthus reaction in the cornea: a preliminary communication. Mod Probl Ophthalmol 16: 155–160

    Google Scholar 

  183. Cochrane CG, Koffler D (1973) Immune complex disease in experimental animals and man. Adv Immunol 16: 185–264

    Google Scholar 

  184. Wilson CB, Dixon FJ (1971) Quantitation of acute and chronic serum sickness in the rabbit. J Exp Med 134 (Suppl): 7–18

    Google Scholar 

  185. Brentjens JR, O'Connell DW, Albini B, Andres GA (1975) Experimental chronic serum sickness in rabbits that received daily multiple and high doses of antigen: a systemic disease. Ann NY Acad Sci 254: 603–613

    Google Scholar 

  186. Aronson SB. Patterns in experimental uveitis (1968) Arch Ophthalmol 79: 763–767

    Google Scholar 

  187. Bito LZ (1974) The effects of experimental uveitis on anterior uveal prostaglandin transport and aqueous humor composition. Invest Ophthalmol 13: 959–966

    Google Scholar 

  188. Lanzieri M (1965) Passive uveal anaphylaxis in guinea pigs. J Immunol 95: 651–655

    Google Scholar 

  189. Silverstein AM, Welter S, Zimmerman LE (1961) A progressive immunization reaction in the actively sensitized rabbit eye. J Immunol 86: 312–323

    Google Scholar 

  190. Cole DF, Unger WG (1973) Prostaglandin as mediators for the responses of the eye to trauma. Exp Eye Res 17: 357–368

    Google Scholar 

  191. Zimmerman LE, Silverstein AM (1959) Experimental ocular hypersensitivity. Histopathologic changes observed in rabbits receiving a single injection of antigen into the vitreous. Am J Ophthalmol 48 (Suppl): 447–465

    Google Scholar 

  192. Hasty ND, Higginbotham RW, Andrews JS, Elliott JH (1971) Nonhematogenous interocular protein transfer. I. Validity and possible routes. Arch Ophthalmol 85: 309–314

    Google Scholar 

  193. Hall JM, Pribnow JF (1972) Responses of the reticuloendothelial system of the rabbit to intraocular injections of foreign protein. Cell Immunol 5: 419–425

    Google Scholar 

  194. Silverstein AM (1963) Effect of X-irradiation on the development of immunogenic uveitis. Invest Ophthalmol 2: 58–62

    Google Scholar 

  195. Smith RE, Jensen AD, Silverstein AM (1969) Antibody formation by single cells during experimental immunogenic uveitis. Invest Ophthalmol 8: 373–380

    Google Scholar 

  196. Seegal BC, Seegal D, Khorazo D (1933) Local organ hypersensitiveness. V. The fate of antigen and the appearance of antibodies during the development of hypersensitiveness in the rabbit eye. J Immunol 25: 207–220

    Google Scholar 

  197. Hohki T, Youasa T, Murai Y, Mimura Y (1971) Histopathological studies on immunological uveitis. Acta Soc Ophthalmol Jpn 75: 1565–1568

    Google Scholar 

  198. Hall JM, Pribnow JF (1979) Delayed hypersensitivity following intravitreal immunization with bovine gamma globulin: preliminary observations. In: Silverstein AM, O'Connor GR (eds) Immunology and Immunopathology of the Eye. New York, Masson USA, pp 365–369

    Google Scholar 

  199. Hall JM (1971) Specificity of antibody formation after intravitreal immunization with bovine gamma globulin and ovalbumin I. Primary response. Invest Ophthalmol 10: 775–783

    Google Scholar 

  200. Hall JM, O'Connor GR (1970) Correlation between ocular inflammation and antibody production II. Hemolytic plaque formation by cells of the uveal tract. J Immunol 140: 440–447

    Google Scholar 

  201. Hall JM, Pribnow JF (1974) Specificity of antibody formation after intravitreal immunization with bovine gamma globulin and ovalbumin. II. Nonspecific enhancement of the secondary response. Cell Immunol 11: 64–73

    Google Scholar 

  202. Shimada K, Silverstein AM (1975) Local antibody formation within the eye: a study of immunoglobulin class and antibody specificity. Invest Ophthalmol 14: 573–583

    Google Scholar 

  203. Witmer RH (1955) Antibody formation in rabbit eye studied with fluorescein-labeled anti-body. Arch Ophthalmol 53: 811–816

    Google Scholar 

  204. Hall JM, O'Connor GR (1970 Correlation between ocular inflammation and antibody production. I. Serum antibody response following intravitreal immunization with protein antigens. J Immunol 104: 432–439

    Google Scholar 

  205. Davanger M, Pedersen OØ (1978) The ciliary body and the suspension of the lens in rabbits: a scanning electron microscopy study. Acta Ophthalmol 56: 127–138

    Google Scholar 

  206. Hall JM, Pribnow JF (1976) Non-specific stimulation of a secondary ocular antibody response. Invest Ophthalmol 15: 863–866

    Google Scholar 

  207. Shimada K, Silverstein AM (1975) Induction of booster antibody formation without specific antigenic drive. Cell Immunol 18: 484–488

    Google Scholar 

  208. Aronson SB, Howes EL, Fish MB, Pollycove M, O'Day DN (1974) Ocular blood flow in experimentally induced immunogenic uveitis. Arch Ophthalmol 91: 60–65

    Google Scholar 

  209. Audain VP, Vethamany VG, Quigley J, Ghose T (1978) An experimental model of acute immune-complex uveitis. Can J Ophthalmol 13: 96–101

    Google Scholar 

  210. Levine RA, Ward PA (1970) Experimental acute immunologic ocular vasculitis. Am J Ophthalmol 679: 1023–1031

    Google Scholar 

  211. Oniki S, Inoue Y, Kawata K (1976) Ocular Arthus reaction with reference to immunologic retinal vasculitis: Its possible relation to Behçet's disease. Jpn J Ophthalmol 20: 41–50

    Google Scholar 

  212. Shabo AL, Maxwell DS (1976) Insulin-induced immunogenic retinopathy resembling the retinitis proliferans of diabetes. Trans Am Acad Ophthalmol Otolaryngol 81: 497–508

    Google Scholar 

  213. Shabo AL, Maxwell DS (1976) Experimental immunogenic proliferative retinopathy in monkeys. Am J Ophthalmol 83: 471–480

    Google Scholar 

  214. Shabo AL, Maxwell DS, Shintako IP, Kreiger AE, Straatsma BR (1977) Experimental immunogenic rubeosis iridis. Invest Ophthalmol Vis Sci 16: 343–352

    Google Scholar 

  215. Sher NA, Foon KA, Fishman ML, Brown TM (1976) Demonstration of macrophage chemotactic factors in the aqueous humor during experimental immunogenic uveitis in rabbits. Infect Immun 13: 1110–1116

    Google Scholar 

  216. Silverstein AM (1964) Uveal hypersensitivity reactions to protein antigens. In: Maumenee AE, Silverstein AM (eds) Immunopathology of Uveitis. Baltimore, Williams and Wilkins, pp 209–217

    Google Scholar 

  217. Todo M (1969) Immuno-histological studies of experimental allergic endophthalmitis. Acta Soc Ophthalmol Jpn 73: 269–282

    Google Scholar 

  218. Uusitalo H (1984) An experimental uveitis induced by bovine serum albumin: a transmission and scanning electron microscopic study. Acta Ophthalmol 62: 413–424

    Google Scholar 

  219. Woods AC, Friedenwald JS, Wood RM (1955) The histopathology of the acute and chronic ocular hypersensitive reactions in the experimental rabbit. Am J Ophthalmol 40: 631–647

    Google Scholar 

  220. Faure J-P (1973) Ocular hypersensitivity to foreign proteins and to microbial antigens. In: Campinchi R et al. (eds) Uveitis, Immunologic and Allergic Phenomena. Translated and revised by Golden B, Givoiset MM. Springfield, Thomas, pp 27–101

    Google Scholar 

  221. Silverstein AM, Zimmerman LE (1959) Immunogenic endophthalmitis produced in the guinea pig by different pathogenetic mechanisms. Am J Ophthalmol 48 (Suppl): 435–447

    Google Scholar 

  222. Friedlaender MH, Howes EL, Hall JM, Krasnobrod H, Wormstead MA (1978) Histopathology of delayed hypersensitivity reactions in the guinea pig uveal tract. Invest Ophthalmol Vis Sci 17: 327–335

    Google Scholar 

  223. Friedlaender MH, Cyr R (1979) Ocular findings in systemic cutaneous basophil hypersensitivity. Invest Ophthalmol Vis Sci 18: 964–969

    Google Scholar 

  224. Howes EL, Char DH, Christensen M (1982) Aqueous immune complexes in immunogenic uveitis. Invest Ophthalmol Vis Sci 23: 715–718

    Google Scholar 

  225. Kulkarni PS, Bhattacherjee P, Eakins KE, Srinivasan BD (1981) Anti-inflammatory effects of betamethasone phosphate, dexamethasone phosphate and indomethacin on rabbit ocular inflammation induced by bovine serum albumin. Curr Eye Res 1: 43–47

    Google Scholar 

  226. Schlaegel TF (1944) A comparison of the ocular reactions of pigmented and albino rabbits to normal horse serum: intraocular followed by intravenous injection. Am J Ophthalmol 27: 137–146

    Google Scholar 

  227. Seegal D, Seegal BC (1931) Local organ hypersensitiveness. III. Further observations on its experimental production in the rabbit eye. J Exp Med 54: 249–263

    Google Scholar 

  228. Seegal D, Seegal BC (1931) Local organ hypersensitiveness. IV. Inflammation produced in the actively sensitized rabbit eye by the introduction of homologous antigen into the gastrointestinal tract. J Exp Med 54: 265–269

    Google Scholar 

  229. Bito LZ, Wallenstein MC (1977) Transport of prostaglandins across the blood-aqueous barriers and the physiological significance of these absorptive transport processes. In: Bito LZ, Davson H, Fenstermacher JU (eds) The Ocular and Cerebrospinal Fluids. London, Academic Press, pp 229–243

    Google Scholar 

  230. Gamble NC (1968) The ocular Auer reaction and its possible relationship to recurrent uveitis. In: Aronson SB et al. (eds) Clinical Methods in Uveitis. St. Louis, Mosby, pp 147–156

    Google Scholar 

  231. Brinkman CJJ, Winkens HJ, Broekhuyse RM (1979) Experimental uveitis in isolated humeral and cellular immunity. Graefes Arch Klin Exp Ophthalmol 210: 19–30

    Google Scholar 

  232. Carmichael LE (1965) The pathogenesis of ocular lesions of infectious canine hepatitis. II. Experimental ocular hypersensitivity produced by the virus. Pathol Vet 2: 344–359

    Google Scholar 

  233. Okada M, Shimada K (1980) The continuous and quantitative observation of permeability changes of the blood-aqueous barrier in allergic inflammation of the eye. Invest Ophthalmol Vis Sci 19: 169–175

    Google Scholar 

  234. Nicolle MM, Abt G (1908) A general conception of antibodies and their effects: antibody to albumins and cells. Ann Inst Pasteur (Paris) 22: 132–171

    Google Scholar 

  235. Gamble CN, Aronson SB, Brescia FB (1970) Experimental uveitis. I. The production of recurrent immunologic (Auer) uveitis and its relationship to increased uveal vascular permeability. Arch Ophthalmol 84: 321–330

    Google Scholar 

  236. Schnellman DC, Aronson SB (1966) The relationship between autoantibody and sympathetic uveitis. Arch Ophthalmol 75: 213–217

    Google Scholar 

  237. Wegefarth P, Weed LH (1914) Studies on cerebro-spinal fluid. VII. The analogous processes of the cerebral and ocular fluids. J Med Res 31: 167–176

    Google Scholar 

  238. Hoffman SA, Shucard DW, Harbeck DJ, Hoffman AA (1978) Chronic immune complex disease: behavioral and immunological correlates. J Neuropathol Exp Neurol 37: 426–436

    Google Scholar 

  239. Peress NS, Miller F, Palu W (1977) The choroid plexus in passive serum sickness. J Neuropathol Exp Neurol 36: 561–566

    Google Scholar 

  240. Peress NS, Tompkins DC (1980) Rat CNS in experimental chronic serum sickness: integrity of the zonulae occludentes of the choroid plexus epithelium and brain endothelium in experimental chronic serum sickness. Neuropathol Appl Neurobiol 5: 279–288

    Google Scholar 

  241. Peress NS (1980) Immune complex deposition in the ciliary process of rabbits with acute and chronic serum sickness. Exp'Eye Res 30: 371–378

    Google Scholar 

  242. Wong VG, Anderson RR, McMaster PRB (1971) Endogenous immune uveitis: the role of serum sickness. Arch Ophthalmol 85: 93–102

    Google Scholar 

  243. Kaplan HJ, Diamond JG, Brown SA (1979) Surgical induction of protein uveitis in the rabbit. In: Silverstein AM, O'Connor GR (eds) Immunology and Immunopathology of the Eye. New York, Masson USA, pp 93–96

    Google Scholar 

  244. Gamble CN, Aronson SB, Brescia FB (1970) Experimental uveitis. II. The pathogenesis of recurrent immunologic (Auer) uveitis. Arch Ophthalmol 84: 331–341

    Google Scholar 

  245. Theofilopoulos AN, Dixon FJ (1979) The biology and detection of immune complexes. Adv Immunol 28: 89–220

    Google Scholar 

  246. Theofilopoulos AN, Dixon FJ (1980) Immune complexes in human disease. A Review. Amer J Pathol 100: 531–591

    Google Scholar 

  247. Kessler HS, Cubberly M, Manski W (1971) Eye Changes in autoimmune NZB and NZB x NZW mice. Comparison with Sjogren's syndrome. Arch Ophthalmol 85: 211–219

    Google Scholar 

  248. Pertschuk LP, Szabo K, Vuletin JC, Rainford EA (1977) Ocular immunopathology in murine lupus. Arch Pathol Lab Med 101: 122–124

    Google Scholar 

  249. Cello RM (1964) An experimental model for the study of endogenous uveitis. In: Maumenee AE, Silverstein AM (eds) Immmunopathology of Uveitis. Baltimore, Williams and Wilkins, pp 243–250

    Google Scholar 

  250. Witmer RH (1964) The origin of ocular antibodies. In: Maumenee AE, Silverstein AM (eds) Immunopathology of Uveitis. Baltimore, Williams and Wilkins, pp 111–121

    Google Scholar 

  251. Jensen PR, Aronson SB, Pollycove M, Yamamoto E (1967) Mechanism of host response in the eye. III. Interocular protein transfer. Arch Ophthalmol 77: 814–817

    Google Scholar 

  252. Larsen G (1961) Experimental uveitis. A histopathologic study with special reference to the mast cell. Acta Ophthalmol 39: 231–258

    Google Scholar 

  253. Schmedtje JF (1959) Sympathectomy and immunologically induced bilateral eye reactions in the rabbit. Arch Ophthalmol 61: 453–463

    Google Scholar 

  254. Pettit TH, Kimura SJ, Uchida Y, Peters H (1965) Herpes simplex uveitis: An experimental study with the fluorescein-labeled antibody technique. Invest Ophthalmol 4: 349–357

    Google Scholar 

  255. Gruntzig J, Schicha H, Kiem J, Becker V, Feinendegen LE (1977) Studies on the lymph drainage of the eye. I. Quantitative investigations of the lymph drainage from the rabbit orbit with radioactive tracers. Klin Mbl Augenheilk 170: 713–720

    Google Scholar 

  256. Goodpasture EW, Treague O (1923) Experimental production of herpetic lesions in organs and tissues of the rabbit. J Med Res 44: 121–138

    Google Scholar 

  257. Forster S, Mead A, Sears M (1979) An interophthalmic communicating artery as explanation for the consensual irritative response of the rabbit eye. Invest Ophthalmol Vis Sci 18:161–165

    Google Scholar 

  258. Hylkema HA, Rathman WM, Kijlstra A (1983) Deposition of immune complexes in the mouse eye. Exp Eye Res 37: 257–265

    Google Scholar 

  259. Walton KW (1973) Studies on the pathogenesis of corneal archus formation. 1. The human corneal arcus and its relation to atherosclerosis as studied by immunofluorescence. J Pathol 111:263–274

    Google Scholar 

  260. Levinsky RJ, Lehner T (1978) Circulating soluble immune complexes in recurrent oral ulcération and Behçet's syndrome. Clin Exp Immunol 32: 193–198

    Google Scholar 

  261. Zeek PM (1953) Periarteritis nodosa and other forms of necrotizing angiitis. New Engl J Med 248: 764–772

    Google Scholar 

  262. Bird AC, Anderson J, Fuglsang H (1976) Morphology of posterior segment lesions of the eye in patients with onchocerciasis. Br J Ophthalmol 60: 2–20

    Google Scholar 

  263. Marak GE, Font RL, Alepa FP (1976) Experimental lens induced granulomatous endophthalmitis. Mod Probl Ophthalmol 16: 75–79

    Google Scholar 

  264. Spector WG, Heesom N (1969) The production of granulomata by antigen-antibody complexes. J Pathol Bacteriol 98: 31–39

    Google Scholar 

  265. Niederkorn JY, Streilein JW (1982) Induction of anterior chamber-associated immune deviation (ACAID) by allogeneic intraocular tumors does not require splenic metastases. J Immunol 128: 2470–2474

    Google Scholar 

  266. Waldrep JC, Kaplan HJ (1983) Anterior chamber associated immune deviation induced by TNP-splenocytes (TNP-ACAID). I. Systemic Ophthalmol Vis Sci 24: 1086–1092

    Google Scholar 

  267. Schreiner GF, Cotran RS, Pardo V, Unanue ER (1978) A mononuclear cell component in experimental immunological glomerulonephritis. J Exp Med 147: 369–384

    Google Scholar 

  268. Lambert PH, Dixon FJ, Zubler RH, Agnello V, Cambiaso C, Casali P, Clark J, Cowdery JS, McDuffie FC, Hay FC, MacLennan ICM, Masson P, Müller-Eberhard HJ, Penttinen K, Smith M, Tappeiner G, Theofilopoulos AN, Verroust P (1978) A WHO collaborative study for the evaluation of eighteen methods of detecting immune complexes in serum. J Clin Lab Immunol 1: 1–15

    Google Scholar 

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  1. Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA

    L. David Ormerod

  2. Department of Ophthalmology, The Eye Research Institute of Retina Foundation, Boston, MA, USA

    L. David Ormerod

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Ormerod, L.D. Immunological concepts and the eye: A review of the classical and ocular Arthus reactions. Doc Ophthalmol 64, 387–417 (1986). https://doi.org/10.1007/BF00212061

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Key words

  • antigen-antibody complex
  • Arthus phenomenon
  • ocular Arthus reactions
  • delayed hypersensitivity
  • keratitis
  • uveitis
  • ocular physiology
  • animal models