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Evolutionary relationship between human and mouse immunoglobulin kappa light chain variable region genes

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Abstract

Similar to the Igh-V multigene family, the human or mouse Igk-V repertoirer is a distorted continuum of homologous genes that may be grouped into families displaying >80% nucleic acid sequence similarity among their members. systematic interspecies sequence comparisons reveal that most human Igk-V gene families exhibit clear homology to mouse Ogk-V families (sequence similarity >74%). A hypothetical phylogenetic tree of Igk-V genes predicts that a minimum of seven Igk-V genes/families predate mammalian radiation. In two cases, several interrelated mouse Igk-V families exhibit phylogenetic equidistance with just one human Igk-V family, implying a more pronounced divergence for the elevated number of Igk-V gene families in the mouse. Mouse-human Igk-V comaprisons, moreover, illustrate how expansion, contraction, and perhaps deletion of Igk-V gene families shape the Igk-V repertoire during mammalian evolution.

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Authors and Affiliations

  1. Institut d'Embryologie du CNRS et du Collège de France, Nogent-sur-Marne, France

    Guido Kroemer, Alain Bernot & Charles Auffray

  2. Centro de Biología Molecualr, CSIC, Universidad Autónoma, Madrid, Spain

    Guido Kroemer

  3. Institute for General and Experimental Pathology, University of Innsbruck Medical School, Innsbruck, Austria

    Arno Helmberg & Reinhard Kofler

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  1. Guido Kroemer
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  2. Arno Helmberg
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  4. Charles Auffray
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  5. Reinhard Kofler
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Kroemer, G., Helmberg, A., Bernot, A. et al. Evolutionary relationship between human and mouse immunoglobulin kappa light chain variable region genes. Immunogenetics 33, 42–49 (1991). https://doi.org/10.1007/BF00211694

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  • DOI: https://doi.org/10.1007/BF00211694

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