Abstract
The effect of natural lymphotoxin (n-LT) on CD4+ MOLT-4 cells and those cells producing human immunodeficiency virus (HIV), MOLT-4/ HIVHTLV-IIIB cells, was studied. Four days after treatment with n-LT, a significant cytotoxic/cytostatic effect was observed predominantly on MOLT-4/HIVHTLV-IIIB cells. Furthermore, with regard to the production of HIV, an almost 3- to 5-fold increase of viral particles was observed in MOLT-4/HIVHTLV-IIIB cells 6 h after treatment with n-LT. These data indicate the possibility that this cytotoxic factor is one of the responsible molecules in the pathogenesis of the acquired immunodeficiency syndrom (AIDS).
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Matsuyama, T., Hamamoto, Y., Kobayashi, S. et al. Enhancement of human immunodeficiency virus production by natural lymphotoxin. Med Microbiol Immunol 177, 181–187 (1988). https://doi.org/10.1007/BF00211217
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DOI: https://doi.org/10.1007/BF00211217