Abstract
Autosomal dominant cyclic hematopoiesis (ADCH), or cyclic neutropenia, is a genetic disorder characterized by cyclic oscillations of neutrophils and other blood cells. To determine if the gene for ADCH mapped within the major hematopoietic regulatory gene cluster at 5q23.3–q33.3, we tested five families with ADCH for genetic linkage between the disorder and loci on chromosome 5q. Two-point analyses gave significant evidence in favor of excluding linkage between ADCH and the hematopoietic genes granulocyte-macrophage colony-stimulating factor (CSF), interleukins 3, 4, 5, and 9, and the receptor of macrophage-CSF. Furthermore, the exclusion data provide evidence for rejecting the hypothesis that ADCH may be encoded by a new gene mapping within this cluster.
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References
Dale DC, Hammond WP IV (1988) Cyclic neutropenia: a clinical review. Blood Rev 2:178–185
Dietzsch E, Retief AE, Lotze MJ, Warnich L, Nicholson DL, Fox MF, Fricke J, du Plessis L, Oosthuizen CJ (1986) An anonymous human single copy genomic clone, D5S6 (M4) on chromosome 5 identifies a three allele RFLP. Nucleic Acids Res 14:1923
Frolova EI, Dolganov GM, Mazo IA, Smirnov DV, Copeland P, Stewart C, O'Brien SJ, Dean M (1991) Linkage mapping of the human CSF2 and IL3 genes. Proc Natl Acad Sci USA 88:4821–4824
Kayes LM, Schroeder WT, Marchuk DA, Collins FS, Riccardi VM, Duvic M, Stephens K (1992) The gene for a novel epidermal antigen maps near the neurofibromatosis I gene. Genomics 14:369–376
Krance RA, Spruce WE, Forman SJ, Rosen RB, Hecht T, Hammond WP, Blume KG (1982) Human cyclic neutropenia transferred by allogeneic bone marrow grafting. Blood 60:1263–1266
Kosambi DD (1944) The estimation of map distances from recombination values. Ann Eugen 12:172–175
Lathrop GM, Lalouel JM, Julier C, Ott J (1984) Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci USA 81:3443–3446
Le Beau MM (1992) Deletions of chromosome 5 in malignant myeloid disorders. Cancer Surv 15:143–159
Leeuwen BH van, Martinson ME, Webb GC, Young IG (1989) Molecular organization of the cytokine gene cluster, involving the human IL-3, IL-4, IL-5, and GM-CSF genes, on human chromosome 5. Blood 73:1142–1148
Metcalf D (1991) Control of granulocytes and macrophages: molecular, cellular, and clinical aspects. Science 254:529–533
Murray JC, Duyk GM, Sheffield V, Weber JL, Buetow KH, Weir RF (1993) Cooperative Human Linkage Center Report 1 (1):9
NIH/CEPH Collaborative Mapping Group (1992) A comprehensive genetic linkage map of the human genome. Science 258:67–86
Ott J (1974) Estimation of the recombinaton fraction in human pedigrees: efficient computation of the likelihood for human linkage studies. Am J Hum Genet 26:588–597
Polymeropoulos MH, Xiao H, Rath DS, Merril CR (1991) Dinucleotide repeat polymorphism at the human c-fms protooncogene for the CSF-1 receptor (CSF1R). Nucleic Acids Res 19:1160
Takahashi M, Yoshida MC, Satoh H, Hilgers J, Yaoita Y, Honjo T (1989) Chromosomal mapping of the mouse IL-4 and human IL-5 genes. Genomics 4:47–52
Van Cong N, Fichelson S, Gross MS, Sola B, Bordereaux D, Tand MF de, Guilhot S, Gisselbrecht S, Frezal J, Tambourin P (1989) The human homologues of Fim1, Fim2/c-Fms, and Fim3, three retroviral integration regions involved in mouse myeloblastic leukemias, are respectively located on chromosomes 6p23, 5p33, and 3q27. Hum Genet 81:257–263
Warrington JA, Bailey SK, Armstrong E, Aprelikova O, Alitalo K, Dolganov GM, Wilcox AS, Sikela JM, Wolfe SF, Lovett M, Wasmuth JJ (1992) A radiation hybrid map of 18 growth factor, growth factor receptor, hormone receptor, or neurotransmitter receptor genes on the distal region of the long arm of chromosome 5. Genomics 13:803–808
Weber JL, Polymeropoulos MH, May PE, Kwitek AE, Xiao H, McPherson JD, Wasmuth JJ (1991) Mapping of human chromosome 5 microsatellite DNA polymorphisms. Genomics 11:695–700
Weiffenbach B, Falls K, Bricker A, Hall L, McMahon J, Wasmuth J, Funanage V, Donis-Keller H (1991) A genetic linkage map of human chromosome 5 with 60 RFLP loci. Genomics 10:173–185
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Palmer, S.E., Dale, D.C., Livingston, R.J. et al. Autosomal dominant cyclic hematopoiesis: exclusion of linkage to the major hematopoietic regulatory gene cluster on chromosome 5. Hum Genet 93, 195–197 (1994). https://doi.org/10.1007/BF00210609
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DOI: https://doi.org/10.1007/BF00210609