This is a preview of subscription content, log in via an institution to check access.
References
Acha-Orbea, H., Shakov, A. N., Scarpellino, L., Kolb, E., Muller, V., Vessaz-Shaw, A., Fuchs, R., Blochlinger, K., Rollini, P., Billotte, J., Sarafidou, M., MacDonald, H. R., and Diggelman, H. Clonal deletion of Vβ14-bearing T cells in mice transgenic for mammary tumor virus. Nature 350: 207–211, 1991
Acha-Orbea, H., Scarpellino, L., Shakov, A. N., Held, W., and MacDonald, H. R. Inhibition of mouse mammary tumor virus-induced T cell responses by antibodies to an open reading frame protein. J Exp Med 176: 1769–1772, 1992
Choi, Y., Kappler, J. W., and Marrack, P. A superantigen encoded in the open reading frame of the 3′ long terminal repeat of mouse mammary tumor virus. Nature 350: 203–207, 1991
Fairchild, S., Knight, A. M., Dyson, P. J., and Tomonari, K. Cosegregation of a gene encoding a deletion ligand for Tcrb-V3+ T cells with Mtv-3. Immunogenetics 34: 227–230, 1991
Fairchild, S., Rosenwasser, O. A., Dyson, P. J., and Tomonari, K. Tcrb-V3+ T-cell deletion and a new mouse mammary tumor provirus, Mtv-44. Immunogenetics 36: 189–194, 1992
Frankel, W. N., Rudy, C., Coffin, J. M., and Huber, B. T. Linkage of Mls genes to endogenous mouse mammary tumor viruses of inbred mice. Nature 349: 526–528, 1991
Held, M. P., Shakov, A. N., Waanders, G., Scarpellino, L., Luethy, R., Kraehenbul, J-P., MacDonald, H. R., and Acha-Orbea, H. An exogenous mouse mammary tumor virus with properties of Mls-1a (Mtv-7). J Exp Med 175: 1623–1633, 1992
Hügin, A. W., Vacchio, M. S., and Morse III, H. C. A virus encoded “superantigen” in a retrovirus-encoded immunodeficiency syndrome of mice. Science 252: 424–427, 1991
Jouvin-Marche, E., Cazenave, P-A., Voegtle, D., and Marche, P. N. Vβ17 T-cell deletion by endogenous mammary tumor virus in wild-type-derived mouse strain. Proc Natl Acad Sci USA 89: 3232–3235, 1992
Kappler, J. W., Roehm, N., and Marrack, P. T cell tolerance by clonal elimination in the thymus. Cell 49: 273–280, 1987
Kappler, J. W., Staerz, U., White, J., and Marrack, P. C. Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex. Nature 332: 35–40, 1988
Lafon, M., Lafage, M., Martinez-Arends, A., Ramirez, R., Vuillier, F., Lotteau, V., and Scott-Algara, D. Evidence for a viral superantigen in humans. Nature 358: 507–510, 1992
MacDonald, H. R., Schneider, R., Lees, R. K., Howe, R. C., Acha-Orbea, H., Festenstein, H., Zinkernagel, R. M., and Hengartner, H. T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa encoded antigens. Nature 332: 40–45, 1988
Mohan, N., Mottershead, D., Subramanyam, M., Beutner, U., and Huber, B. T. Production and characterization of an Mls-1-specific antibody. J Exp Med 177: 351–358, 1993
Pullen, A. M., Choi, Y., Kushnir, E., Kappler, J. W., and Marrack, P. The open reading frames in the 3′ long terminal repeats of several mouse mammary tumor virus integrants encode Vβ3-specific superantigens. J Exp Med 175: 41–47, 1992
Rudy, C. K., Klaus, E., Palmer, R., and Huber, B. T. Mls-1-like superantigen in the MA/MyJ mouse is encoded by a new mammary tumor virus that is distinct from Mtv-7. J Exp Med 175: 1613–1621, 1992
Sanger, F., Nicklen, S., and Coulson, A. R. DNA sequencing with chain termination inhibitors. Proc Natl Acad Sci USA 74: 5463–5469, 1977
Tomonari, K. and Fairchild, S. Positive and negative selection of Tcrb-V6+ T cells. Immunogenetics 36: 230–237, 1992
Tomonari, K., Fairchild, S., and Rosenwasser, O. A. Tcrb-V3+ T-cell deletion and a mouse mammary tumor provirus, Mtv-27. Immunogenetics 36: 302–305, 1992
Winslow, G. M., Scherer, M. T., Kappler, J. W., and Marrack, P. Detection and biochemical characterization of the mouse mammary tumor virus 7 superantigen (Mls-1a). Cell 71: 719–730, 1992
Woodland, D. L., Lund, F. E., Happ, M. P., Blackman, M. E., Palmer, E., and Corley, R. B. Endogenous superantigen expression is controlled by mouse mammary tumor proviral loci. J Exp Med 174: 1255–1258, 1991
Author information
Authors and Affiliations
Additional information
The nucleotide sequence data reported in this paper have been submitted to the GenBank nucleotide sequence database and have been assigned the accession number Z19 515.
Correspondence to: K. Tomonari.
Rights and permissions
About this article
Cite this article
Rosenwasser, O.A., Fairchild, S. & Tomonari, K. New superantigen specificity created by two amino acid replacements. Immunogenetics 38, 367–369 (1993). https://doi.org/10.1007/BF00210480
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00210480