Abstract
Neurotrophic factors are essential neurone survival promoting molecules that are often secreted and that bind to neuronal cell surface receptors. Glial cell line-derived neurotrophic factor, GDNF, is a potent neurotrophic factor that promotes the survival of dopaminergic neurones in cultures including embryonic neuronal cultures. We have mapped the gene encoding GDNF by two independent methods: using a cell hybrid panel and by fluorescent in situ hybridisation. We find GDNF lies on the short arm of human chromosome 5, at 5p13.1-p13.3
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Anand R, Riley JH, Butler R, Smith JC, Markham AF (1990) A 3.5 genome equivalent multi access YAC library: construction, characterisation, screening and storage. Nucleic Acids Res 18: 1951–1955
Brant SR, Bernstein M, Wasmuth JJ, Taylor EW, McPherson JD, Li X, Walker S, Pouyssgur J, Donowitz M, Tse C-M, Jabs EW (1993) Physical and genetic mapping of a human apical epithelial Na+/H+ exchanger (NHE3) isoform to chromosome 5p15. 3. Genomics 15: 668–672
Dana S, Wasmuth JJ (1982) Linkage of the leuS, emtB, and chr genes on chromosome 5 in humans and expression of human genes encoding protein synthetic components in human-Chinese hamster hybrids. Somatic Cell Genet 8: 245–264
Henderson CE, Phillips HS, Pollock RA, Davies AM, Lemeulle C, Armanini M, Simpson LC, Moffet B, Vandlen RA, Koliatsos VE, Rosenthal A (1994) GDNF: a potent survival factor for motorneurons present in peripheral nerve and muscle. Science 266: 1062–1064
Hernandez D, Yulug IG, Egan SE, Fisher EMC (1994) Mapping the gene which encodes phosphatidylinositol specific phospholipase C-g2 in the human and the mouse. Genomics 23: 504–507
Keppen LD, Gollin SM, Edwards D, Sawyer J, Wilson W, Overhauser J (1992) Clinical phenotype and molecular analysis of a three generation family with an interstitial deletion of the short arm of chromosome 5. Am J Med Genet 44: 356–360
Khodr GS, Cadena G, Le KL, Kagan Hallet KS (1982) Duplication (5q13 leads to pter): prenatal diagnosis and review of the literature. Am J Med Genet 12: 43–49
Lin L-FH, Doherty DH, Lue JD, Bektesh S, Collins F (1993) GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurones. Science 260: 1130–1132
Phelan MC, Morton CC, Stevenson RE, Tanzi RE, Stewart GD, Watkins PC, Gusella JF, Amos JA (1988) Molecular and cyotogenetic characterization of a de novo t(5p;21q) in a patient previously diagnosed as monosomy 21. Am J Hum Genet 43: 511–519
Yulug IG, Egan SE, See CG, Fisher EMC (1994) Mapping GRB2, a signal transduction gene in the human and the mouse. Genomics 22: 313–318
Yulug IG, See CG, Fisher EMC (1995) The DAD1 protein, whose defect causes apoptotic cell death, maps to human chromosome 14. Genomics 26: 433–435
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Bermingham, N., Hillermann, R., Gilmour, F. et al. Human glial cell line-derived neurotrophic factor (GDNF) maps to chromosome 5. Hum Genet 96, 671–673 (1995). https://doi.org/10.1007/BF00210297
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DOI: https://doi.org/10.1007/BF00210297