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Aspects of cellular proliferation during follicular atresia in the dog ovary

Cell and Tissue Research volume 219, pages 173–183 (1981)Cite this article

Summary

Autoradiography after pulse labelling with [3H] thymidine was applied to investigate the proliferation processes in the granulosa and theca related to follicular atresia of the dog ovary during metestrus.

The number of proliferating cells depends on the follicle type and its atretic stage. There is less proliferation in smaller secondary follicles than either in larger ones or tertiary follicles. While in early atresia tertiary follicles show the highest labelling indices, in advanced atresia the larger secondary follicles are those with the highest values. For each follicle type a decline in the labelling indices can be observed from early to terminal atresia. Tertiary follicles show a precipitous decrease in the labelling index between early and advanced atresia. There is a continuous gradient of proliferation from the center of the follicle over the peripheral granulosa to the theca. In tertiary follicles, an inverse correlation between labelling and necrosis of granulosa cells can be observed.

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Affiliations

  1. Abteilung für Klinische Morphologie der Universität Ulm, Ulm, Bundesrepublik Deutschland

    Katharina Spanel-Borowski, Friedrich Trepel, Peter Schick & Christoph Pilgrim

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  1. Katharina Spanel-Borowski
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  2. Friedrich Trepel
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  3. Peter Schick
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  4. Christoph Pilgrim
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Spanel-Borowski, K., Trepel, F., Schick, P. et al. Aspects of cellular proliferation during follicular atresia in the dog ovary. Cell Tissue Res. 219, 173–183 (1981). https://doi.org/10.1007/BF00210026

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  • DOI: https://doi.org/10.1007/BF00210026

Key words

  • Ovary (dog)
  • Atresia
  • Thymidine
  • Autoradiography