Summary
Captopril [1-(D-3-mercapto-2-methyl-1-oxopropyl)-L-proline (S,S)] is now known to be an inhibitor of angiotensin-converting enzyme. In male mice, the juxtaglomerular cells were examined by electron microscopy 42 h after administration of captopril. Numerous dense granules appeared in the rough endoplasmic reticulum of these cells.
This is a preview of subscription content, log in via an institution to check access.
References
Bing J, Poulsen K, Hackenthal E, Rix E, Taugner R (1980) Renin in the submaxillary gland. J Histochem Cytochem 28:874–880
Caro LG, Palade GE (1964) Protein synthesis, storage, and discharge in the pancreatic exocrine cell. J Cell Biol 20:473–495
Chandra S, Hubbard JC, Skelton FR, Bernardis LL, Kamura S (1965) Genesis of juxtaglomerular cell granules. A physiologic, light and electron microscopic study concerning experimental renal hypertension. Lab Invest 14:1834–1847
De Senarclens CF, Pricam CE, Banichahi FD, Vallotton MB (1977) Renin synthesis, storage, and release in the rat. A morphological and biochemical study. Kidney Int 2:161–169
Gavras H, Brunner HR, Turini G, Kershaw GR, Tifft CP, Cuttelod S, Gavras I, Vukovich RA, McKinstry DN (1978) Antihypertensive effect of the oral angiotensin converting enzyme inhibitor SQ 14225 in man. N Engl J Med 298:991–995
Hoffer AP, Hamilton DW, Fawcett DW (1973) The ultrastructural pathology of the rat epididymis after administration of α-chlorhydrin (U-5897). I. Effects of a single high dose. Anat Rec 175:203–230
Inagami T, Mutakami K (1977) Purification of high molecular weight forms of renin from dog kidney. Circ Res 41: Suppl 2:11–16
Kaneta M, Abe K, Ito T (1979) Juxtaglomerular cells after removal of the submandibular glands in mice. Qualitative and quantitative electron microscopy. Acta Anat Nippon 54:251–259
Matthews PG, McGrath BP, Johnston CI (1979) Hormonal changes with long-term converting enzyme inhibition by captopril in essential hypertension. Clin Sci 57:135s-138s
Ondetti MA, Rubin B, Cushman DW (1977) Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents. Science 196:441–444
Palade GE (1956) Intracisternal granules in the exocrine cells of the pancreas. J Biolphys Biochem Cytol 2:417–422
Peter S, Lazar J, Gross F, Forssman WG (1974) Studies on the juxtaglomerular apparatus. II. Quantitative morphology after adrenalectomy. Cell Tissue Res 151:457–469
Warshawsky H, Haddad A, Gonçalves RP, Valeri V, De Lucca FL (1973) Fine structure of the venom gland epithelium of the south American rattlesnake and radioautographic studies of protein formation by the secretory cells. Am J Anat 138:79–120
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kaneta, M., Abe, K. & Ito, T. Appearance of dense granules in the rough endoplasmic reticulum of the juxtaglomerular cells in mice administered with captopril. Cell Tissue Res. 220, 219–222 (1981). https://doi.org/10.1007/BF00209980
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00209980