Summary
Superoxide dismutase CuZn (SOD1) enzymatic activity was measured in five orangutans (Pongo pygmaeus, PPY) and compared to that of man, chimpanzee, and gorilla. It was found to be increased by a factor of two in one orangutan (Ralfina) and by a factor of 1.5 in the four others. In situ hybridization of the SOD1 cDNA human probe showed a heterozygous intrachromosomal rearrangement of pair PPY XXI, possibly an insertion, in Ralfina. Southern blotting showed that the SOD1 gene is modified in the three orangutans that were investigated and that a further modification of the 5′-end of the gene had occurred in Ralfina. The evolutionary implications of these observations are discussed.
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de Grouchy, J., Nicole, A., Cochet, C. et al. Increased SOD1 enzymatic activity and gene modifications in orangutans: evolutionary implications. Hum Genet 87, 567–570 (1991). https://doi.org/10.1007/BF00209013
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DOI: https://doi.org/10.1007/BF00209013