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Dinucleotide polymorphism at the DXS1178 locus is tightly linked to PGK1 at Xq13

  • DNA Variants
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Abstract

A polymorphic CA repeat (locus name DXS1178) was isolated from a 1-megabase YAC (OTCC) containing the OTC gene, located at Xp21.1. However, amplification in human-rodent hybrid cells and segregation analysis in three CEPH families mapped the DXS1178 locus at Xq13. The mapping ambiguity is apparently caused by the chimeric nature of the OTCC YAC clone.

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References

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Authors and Affiliations

  1. Department of Ophthalmology, Kellogg Eye Center, University of Michigan, 1000 Wall Street, 48 105, Ann Arbor, MI, USA

    Ricardo Fujita, Craig Skolnick & Anand Swaroop

  2. Department of Genetics, Yale University School of Medicine, 06510, New Haven, CT, USA

    Andrew J. Pakstis & Teresa L. Yang-Feng

  3. Department of Human Genetics, Kellogg Eye Center, University of Michigan, 1000 Wall Street, 48 105, Ann Arbor, MI, USA

    Anand Swaroop

Authors
  1. Ricardo Fujita
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  2. Craig Skolnick
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  3. Andrew J. Pakstis
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  4. Teresa L. Yang-Feng
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  5. Anand Swaroop
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Fujita, R., Skolnick, C., Pakstis, A.J. et al. Dinucleotide polymorphism at the DXS1178 locus is tightly linked to PGK1 at Xq13. Hum Genet 95, 467–468 (1995). https://doi.org/10.1007/BF00208981

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  • DOI: https://doi.org/10.1007/BF00208981

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