Abstract
A PstI polymorphism in the 3′ flanking region of the p21CiP1/Waf1 cyclin-dependent kinase inhibitor gene is described. DNA sequencing analysis identified a C→T base substitution in the 3′ flanking region of the gene. This substitution leads to the destruction of a PstI site and results in a biallelic DNA polymorphism. This restriction fragment length polymorphism (RFLP) provides the first known genetic marker for this cell cycle regulatory gene.
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Law, J.C., Deka, A. Identification of a PstI polymorphism in the p21Cip1/Waf1 cyclin-dependent kinase inhibitor gene. Hum Genet 95, 459–460 (1995). https://doi.org/10.1007/BF00208977
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DOI: https://doi.org/10.1007/BF00208977