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An association between α1-antitrypsin phenotype and chronic liver disease

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Summary

The phenotypes of alpha-1-antitrypsin have been analyzed by isoelectric focusing on polyacrylamide gels in 232 healthy Japanese blood donors and in 240 Japanese patients with chronic liver diseases: 69 with chronic active hepatitis, 122 with liver cirrhosis, 41 with hepatocellular carcinoma and 8 with primary biliary cirrhosis. The liver cirrhosis patients had a gene frequency of 0.07 forPI * M3, which was significantly higher (P<0.01) than that (0.03) in blood donors. The gene frequency of PI * M3 was significantly increased in cryptogenic liver cirrhosis (P<0.05), and there was a tendency toward an increased frequency of PI * M3 in post-transfusion groups, and in primary biliary cirrhosis. There were also tendenciestoward increased frequencies of PI * M3 in cryptogenic and post-transfusion groups of patients with chronic active hepatitis. The present study indicates that PI * M3 is a genetic or predisposing factor for chronic liver diseases, especially for cryptogenic and/or non A-non B viral chronic liver disease and also for primary biliary cirrhosis.

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  1. Second Department of Internal Medicine, Tottori University School of Medicine, 683, Yonago, Japan

    Yosuke Kishimoto, Sadako Yamada & Chisato Hirayama

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  1. Yosuke Kishimoto
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  2. Sadako Yamada
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  3. Chisato Hirayama
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Kishimoto, Y., Yamada, S. & Hirayama, C. An association between α1-antitrypsin phenotype and chronic liver disease. Hum Genet 84, 132–136 (1990). https://doi.org/10.1007/BF00208927

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