Summary
A patient who developed full thickness skin damage treated with topical 5-fluorouracil is described. Extensive deep skin loss at sites treated with 5-fluorouracil has not been previously reported. The physician must be aware of the need for frequent examination of patients using this cytotoxic drug.
Similar content being viewed by others
References
Bart BJ, Bean SF (1970) Bullous pemphigoid following the topical use of fluorouracil. Arch Dermatol 102:457
Bennett R, Epstein E, Goette D et al (1985) Current management using 5-fluorouracil cutis 36:218, 227, 233
Brenner S, Shohet J, Krakowski A et al (1984) Mucoid millia. Arch Dermatol 120:300
Burnett JW (1975) Two unusual complications of topical fluorouracil therapy. Arch Dermatol 111:398
Dillaha CJ, Jansen T, Honeycutt MW et al (1965) Further studies with topical 5-fluorouracil. Arch Dermatol 92:410
Falkson G, Schulz EJ (1962) Skin changes in patients treated with 5-fluorouracil. Br J Dermatol 74:229
Goette DK (1983) The treatment of keratoacantoma with topical 5-fluorouracil. Arch Dermatol 119:951
Goette DK, Odom RB (1977) Allergic contact dermatitis to topical fluorouracil. Arch Dermatol 113:1058
Hazen PG, Taub SJ (1984) Basal cell nevus syndrome. Dermatologica 168:287
Miller E (1971) The metabolism and pharmacology of 5-fluorouracil. J Surg Oncol 3:309
Velter WW (1983) Pigmented purpuric dermaosis-like reaction to topical fluorouracil. Arch Dermatol 119:875
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tsur, H., Borenstein, A. & Seidman, D.S. Full thickness skin damage due to topical administration of 5-fluorouracil. Eur J Plast Surg 13, 263–264 (1990). https://doi.org/10.1007/BF00208328
Issue Date:
DOI: https://doi.org/10.1007/BF00208328