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Full thickness skin damage due to topical administration of 5-fluorouracil

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Summary

A patient who developed full thickness skin damage treated with topical 5-fluorouracil is described. Extensive deep skin loss at sites treated with 5-fluorouracil has not been previously reported. The physician must be aware of the need for frequent examination of patients using this cytotoxic drug.

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References

  1. Bart BJ, Bean SF (1970) Bullous pemphigoid following the topical use of fluorouracil. Arch Dermatol 102:457

    Google Scholar 

  2. Bennett R, Epstein E, Goette D et al (1985) Current management using 5-fluorouracil cutis 36:218, 227, 233

    Google Scholar 

  3. Brenner S, Shohet J, Krakowski A et al (1984) Mucoid millia. Arch Dermatol 120:300

    Google Scholar 

  4. Burnett JW (1975) Two unusual complications of topical fluorouracil therapy. Arch Dermatol 111:398

    Google Scholar 

  5. Dillaha CJ, Jansen T, Honeycutt MW et al (1965) Further studies with topical 5-fluorouracil. Arch Dermatol 92:410

    Google Scholar 

  6. Falkson G, Schulz EJ (1962) Skin changes in patients treated with 5-fluorouracil. Br J Dermatol 74:229

    Google Scholar 

  7. Goette DK (1983) The treatment of keratoacantoma with topical 5-fluorouracil. Arch Dermatol 119:951

    Google Scholar 

  8. Goette DK, Odom RB (1977) Allergic contact dermatitis to topical fluorouracil. Arch Dermatol 113:1058

    Google Scholar 

  9. Hazen PG, Taub SJ (1984) Basal cell nevus syndrome. Dermatologica 168:287

    Google Scholar 

  10. Miller E (1971) The metabolism and pharmacology of 5-fluorouracil. J Surg Oncol 3:309

    Google Scholar 

  11. Velter WW (1983) Pigmented purpuric dermaosis-like reaction to topical fluorouracil. Arch Dermatol 119:875

    Google Scholar 

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Tsur, H., Borenstein, A. & Seidman, D.S. Full thickness skin damage due to topical administration of 5-fluorouracil. Eur J Plast Surg 13, 263–264 (1990). https://doi.org/10.1007/BF00208328

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  • DOI: https://doi.org/10.1007/BF00208328

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