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The effect of washout perfusion with beraprost sodium on the no-reflow phenomenon in the rat island flap

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Abstract

Beraprost sodium is a chemically stable PGI2 analog which has antiplatelet and vasodilating properties, its ability to improve survival after prolonged ischemia was tested on the rat epigastric island flap. Forty Sprague-Dawley rats were divided into control (Ringer's lactated) and treated (beraprost sodium) groups and subdivided into two groups of total ischemia (both artery and vein were occluded): 11 and 15 h. After the ischemic period the flaps were slowly perfused with 4 ml of beraprost sodium solution or R/L solution. After seven days the survival areas were documented: Goup 1 (control — 11 h of ischemia): 9.9%; Group 2 (beraprost sodium — 11 h of ischemia): 85.9%; Group 3 (control — 15 h of ischemia): 0%; Group 4 (beraprost sodium — 15 h of ischemia): 48.2%. Using the student's t-test the result demonstrated that beraprost sodium improved flap survival in both the 11 and 15 h of ischemia groups (p<0.005).

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Authors and Affiliations

  1. Department of Plastic Surgery, Kagawa Medical School, Ikenobe 1740-1, 761-07, Mikicho, Kitagun, Kagawa, Japan

    K. Alexandrou, Y. Hata, K. Matsuka & H. Matsuda

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  1. K. Alexandrou
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  2. Y. Hata
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  3. K. Matsuka
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  4. H. Matsuda
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Alexandrou, K., Hata, Y., Matsuka, K. et al. The effect of washout perfusion with beraprost sodium on the no-reflow phenomenon in the rat island flap. Eur J Plast Surg 19, 73–76 (1996). https://doi.org/10.1007/BF00207918

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