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Highly polymorphic region of the human prothrombin (F2) gene

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Summary

We have found a highly polymorphic region in the human prothrombin gene. Our sequence differed from that previously reported at as many as 6 positions in a 225-bp stretch spanning exon 6 and its flanking regions; four of these positions were related to endonuclease restriction sites for AluI, HpaII(MspI), MboII, and NcoI. AluI and HpaII digested all alleles of the Japanese tested. MboII and NcoI restriction fragment length polymorphisms are highly heterozygous and not in linkage disequilibrium; they thus serve as good human DNA markers

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Authors and Affiliations

  1. Otsuka Department of Clinical and Molecular Nutrition, School of Medicine, University of Tokushima, 770, Tokushima, Japan

    Hiroyuki Iwahana, Katsuhiko Yoshimoto & Mitsuo Itakura

Authors
  1. Hiroyuki Iwahana
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  2. Katsuhiko Yoshimoto
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  3. Mitsuo Itakura
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Iwahana, H., Yoshimoto, K. & Itakura, M. Highly polymorphic region of the human prothrombin (F2) gene. Hum Genet 89, 123–124 (1992). https://doi.org/10.1007/BF00207061

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  • DOI: https://doi.org/10.1007/BF00207061

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