Skip to main content
SpringerLink
Log in

Allotype distribution of human T cell receptor β and γ chain genes in Caucasians, Asians and Australian Aborigines: Relevance to chronic hepatitis B

  • Original Investigations
  • Published:
Human Genetics Aims and scope Submit manuscript

Summary

RFLPs of TCR β and γ genes have been analyzed in chronic HBV carriers of three different ethnic populations to determine if there is an association of TCR allotypes with the development of chronic hepatitis B. The RFLPs of TCR β and γ genes were defined respectively by BglII and PvuII genomic fragments on Southern blots. These methods allow allotype assignment. The distribution of TCR β alleles showed ethnic variation, with one allele significantly decreased in Australian Aborigines, but there was no association with chronic hepatitits B. The distribution of TCR γ alleles did not show ethnic variation. However, a significant frequency decrease of one allele occurred in Aboriginal HBV carriers, suggesting the possibility of involvement of TCR γ allotypes in the development of the chronic HBV carrier state in Australian Aborigines.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Beasley RP (1988) Hepatitis B virus: the major etiology of hepatocellular carinoma. Cancer 61:1942–1956

    Google Scholar 

  • Berliner N, Duby AD, Morton CC, Leder P, Seidman JG (1985) Detection of a frequent restriction fragment length polymorphism in the human T cell antigen receptor beta chain locus. A diagnostic tool. J Clin Invest 76:1283–1285

    Google Scholar 

  • Brenner MB, McLean DPJ, Dialinas JL, Strominger JA, Krangel MS (1986) Identification of a putative second T cell receptor. Nature 322:145–147

    Google Scholar 

  • Carding SR, Kyes K, Jenkinson EJ, Kingston R, Bottomly K, Owen J, Hayday AC (1990) Developmentally regulated fetal thymic and extrathymic T-cell receptor γδ gene expression. Genes Develop 4:1304–1315

    Google Scholar 

  • Cavalli-Sforza L (1987) Uses of DNA polymorphism in mapping. In: Zubay (ed) Genetics. Benjamin/Cummings, Menlo Park, pp 619–625

    Google Scholar 

  • Desmet VJ (1988) Liver lesions in hepatitis B viral infection. Yale J Biol Med 61:61–83

    Google Scholar 

  • Felini B, Flenghi L, Pileri S, Pelicci P, Fagioli M, Martelli MF, Moretta L, Ciccone E (1989) Distribution of T cells bearing different forms of the T cell receptor γδ in normal and pathological human tissue. J Immunol 143:2480–2488

    Google Scholar 

  • Gardner I (1991) Host immune responses in HBV infection. 3rd Annual Australian Hepatitis Workshop, Adelaide

  • Knowless DM (1989) Immunotype and antigen receptor gene rearrangement analysis in T cell neoplasia. Am J Pathol 134:761–785

    Google Scholar 

  • Lefranc MP, Rabbits TH (1989) The human T cell receptor γ (TRG) genes. Trends Biochem Sci 14:214–218

    Google Scholar 

  • Li J, Szabo P, Posnett DN (1988) Molecular genotypes of the human T cell receptor y chain. J Immunol 140:1300–1303

    Google Scholar 

  • Maniatis T, Fritsch EF, Sambrook J (1982) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor NY, pp 363–387

    Google Scholar 

  • Mondelli M, Eddelston A (1984) Mechanism of liver cell injury in acute and chronic hepatitis B. Semin Liver Dis 4:47–58

    Google Scholar 

  • Mulvaney DJ (1975) The prehistory of Australia, rev edn. Penguin, Harmondsworth, pp 19–51

    Google Scholar 

  • Owen MJ, Crumpton MJ (1987) The role of class I and II antigens in T cell recognition. Br Med Bul 43:228–240

    Google Scholar 

  • Siu G, Klark SP, Yoshikai Y, Malissen M, Yanagi Y, Strauss E, Mak TW, Hood L (1984) The human T cell receptor is encoded by variable, diversity and joining gene segments that rearrange to generate a complete V gene. Cell 37:393–402

    Google Scholar 

  • Thomas HC, Jacina M, Waters J, Main J (1988) Virus-host interaction in chronic hepatitis B virus infection. Semin Liver Dis 8:342–349

    Google Scholar 

  • Zinkernagel RM, Doherty PC (1979) Studies on the biological role of polymorphic major transplantation antigens determining T cell restriction specificity, function and responsiveness. Adv Immunol 27:51–177

    Google Scholar 

  • Zuckerman AJ (1984) Prevention of hepatocellular carcinoma by immunization against hepatitis B. Int Rev Exp Pathol 27:59–81

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Queensland, 4029, Brisbane, Queensland, Australia

    Purnomo Soeharso & W. G. E. Cooksley

  2. Department of Medicine, University of Queensland, 4029, Brisbane, Queensland, Australia

    Kim M. Summers

  3. Clinical Research Centre, Royal Brisbane Hospital, 4029, Brisbane, Queensland, Australia

    Purnomo Soeharso & W. G. E. Cooksley

Authors
  1. Purnomo Soeharso
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kim M. Summers
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W. G. E. Cooksley
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Soeharso, P., Summers, K.M. & Cooksley, W.G.E. Allotype distribution of human T cell receptor β and γ chain genes in Caucasians, Asians and Australian Aborigines: Relevance to chronic hepatitis B. Hum Genet 89, 59–63 (1992). https://doi.org/10.1007/BF00207043

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00207043

Keywords

Search

Navigation