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Premature centromere division of a translocation-carrier autosome

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Summary

Premature centromere division of an aberrant chromosome 3 was found in a newborn girl with fetal hydrops and in her healthy father, both bearing a familial “balanced” 3p;19q translocation. The out-of-phase separation of a structurally abnormal chromosome may be of pathogenetic significance, the nature of which is not yet understood.

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References

  • Bajnóczky K, Méhes K (1988) Parental centromere separation sequence and aneuploidy in the offspring. Hum Genet 78:286–288

    Google Scholar 

  • Bühler EM, Fessler R, Beutler C, Gargano G (1987) Incidental finding of double minutes (DM), single minutes (SM), homogenously staining regions (HSR), premature chromosome condensation (PCC), and premature centromere division (PCD)? Ann Génét (Paris) 30:75–79

    Google Scholar 

  • Fitzgerald PH (1989) Aberrant chromatid separation and aneuploidy. In: Resnick MA, Vig BK (eds) Mechanisms of chromosome distribution and aneuploidy. Liss, New York, pp 103–110

    Google Scholar 

  • Fitzgerald PH, Archer SA, Morris CM (1986) Evidence for the repeated primary non-disjunction of chromosome 21 as a result of premature centromere division. Hum Genet 72:58–62

    Google Scholar 

  • Méhes K (1978) Non-random centromere division: a mechanism of nondisjunction causing aneuploidy? Hum Hered 28:255–260

    Google Scholar 

  • Méhes K, Bajnóczky K (1981a) Non-random centromere division: analysis of G-banded human chromosomes. Acta Biol Acad Sci Hung 32:55–59

    Google Scholar 

  • Méhes K, Bajnóczky K (1981b) Early centromere division: analysis of G-banded human chromosomes and family investigations (abstract). Clin Genet 19:522

    Google Scholar 

  • Méhes K, Bajnóczky K (1982) Unusually early dividing chromosomes 13–15 in a child with retinoblastoma and 13q deletion. Hum Genet 61:78

    Google Scholar 

  • Moorhead PS, Heyman A (1983) Chromosome studies in patients with Alzheimer disease. Am J Med Genet 14:545–556

    Google Scholar 

  • Tomkins D, Hunter A, Robert M (1979) Cytogenetic findings in Roberts (SC) phocomelia syndrome. Am J Med Genet 41:17–26

    Google Scholar 

  • Vig BK (1981) Sequence of centromere separation: analysis of mitotic chromosomes in man. Hum Genet 57:247–253

    Google Scholar 

  • Vig BK (1983) Sequence of centromere separation: occurrence, ossible significance, and control. Cancer Genet Cytogenet 8:249–274

    Google Scholar 

  • Vig BK (1987) Sequential centromere separation in multicentric chromosmes: relationship to aneuploidy. In: Vig BK, Sandberg AA (eds) Aneuploidy, part A: Incidence and etiology. Liss, New York, pp 265–272

    Google Scholar 

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Authors and Affiliations

  1. Department of Paediatrics, University Medical School of Pécs, József Attila u. 7, H-7623, Pécs, Hungary

    Károly Méhes & György Kosztolányi

Authors
  1. Károly Méhes
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  2. György Kosztolányi
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Méhes, K., Kosztolányi, G. Premature centromere division of a translocation-carrier autosome. Hum Genet 85, 379–380 (1990). https://doi.org/10.1007/BF00206765

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  • DOI: https://doi.org/10.1007/BF00206765

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