Summary
The functional gene coding for nonhistone chromosomal protein HMG-17, a nucleosomal binding protein that may confer unique properties to the chromatin structure of active genes, has been mapped to band 1p36.1. The multiple, nonfunctional, HMG-17 retropseudogenes are scattered over several chromosomes.
This is a preview of subscription content, log in via an institution to check access.
References
Dracopoli NC, Stanger BZ, Lager M, Housman DE (1988) Localization of the FGR protoncogene on the genetic linkage map of human chromosome 1p. Genomics 3:124–128
Einck L, Bustin M (1985) The intracellular distribution and function of the high mobility group chromosomal proteins. Exp Cell Res 156:295–310
Landsman D, Soares N, Gonzalez FJ, Bustin M (1986) Chromosomal protein HMG-17: complete cDNA sequence and evidence for a multigene family. J Biol Chem 261:7479–7484
Landsman D, McBride OW, Bustin M (1989) Human nonhistone chromosomal protein HMG-17: identification, characterization, chromosome localization of RFLPs of a functional gene from the large multigene family. Nucleic Acids Res 17:2301–2314
Mitchell AL, Bale AE, Bustin M, Landsman D, Popescu N, McBride OW (1989) Localization of HMG-17 gene to chromosome band 1p35–36. 1 (abstract). (10th International Workshop on Human Gene Mapping) Cytogenet Cell Genet 51:1045
Pash J, Popescu N, Matocha M, Rapaport S, Bustin M (1990) Proc Natl Acad Sci USA 87:3836–3840
Petersen MB, Economou EP, Slaugenhaupt SA, Chakravarty A, Antonarakis SE (1990) Linkage analysis of human HMG-14 gene on chromosome 21 using a GT dinucleotide repeat as polymeric marker. Genomics 7:136–138
Popescu NC, Amsbaugh SC, DiPaolo JA, Tronick SR, Aaronson SA, Swan DC (1985a) Chromosomal localization of three human ras genes in in situ molecular hybridization. Somat Cell Mol Genet 11:149–155
Popescu NC, Amsbaugh SC, Swan DC, DiPaolo JA (1985b) Induction of chromosome banding by trypsin/EDTA for gene mapping by in situ hybridization. Cytogenet Cell Genet 39:73–74
Srikantha T, Landsman D, Bustin M (1987) Retropseudogenes for chromosomal protein HMG-17. J Mol Biol 197:401–413
Tronick SR, Popescu NC, Cheah MSC, Swan DC, Amsbaugh SC, Lengel CR, DiPaolo TA, Robbins KC (1985) Isolation and hromosomal localization of the human fgr protooncogene, a distinct member of tryosine kinase gene family. Proc Natl Acad Sci USA 82:6595–6599
Weintraub H, Groudine M (1976) Chromosomal subunits in active genes have an altered conformation. Science 193:848–850
Weisbrod S (1982) Active chromatin. Nature 297:289–295
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Popescu, N., Landsman, D. & Bustin, M. Mapping the human gene coding for chromosomal protein HMG-17. Hum Genet 85, 376–378 (1990). https://doi.org/10.1007/BF00206764
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00206764