Summary
The frequency of bleomycin-induced chromatid breaks was studied in cultured lymphocytes from ten fragile X patients and ten healthy controls. The results showed that the frequency of chromatid breaks was significantly higher among fragile X patients than among normal individuals. We suggest that the fragile X patients may be more susceptible to mutagens and carcinogens and, therefore, more prepotent to neoplastic induction.
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Li, SY., Lin, JK. Differential bleomycin susceptibility in cultured lymphocytes of fragile X patients and normal individuals. Hum Genet 85, 267–271 (1990). https://doi.org/10.1007/BF00206743
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DOI: https://doi.org/10.1007/BF00206743