Summary
Processes of magnocellular neurosecretory cells (MNCs) are easily identifiable on the basis of their content in neurosecretory granules in the neuropil of the rostral division of the paraventricular nucleus (PVN) of the domestic fowl. In specimens sacrificed during the winter the synaptic organization of the neuropil and the pattern of synapses ending on neurosecretory processes were studied at the ultrastructural level. Synapses in the rostral part of the PVN neuropil may be divided into three main categories on the basis of their morphology and their content of clear and dense-core synaptic vesicles. These different types of terminals can be attributed to aminergic, peptidergic or other types of synapses. The percent distribution of synapses within these categories differs when all synapses observed in the neuropil or only those ending on MNC processes are compared. Present ultrastructural data obtained in birds support two physiological hypotheses already suggested for mammals, i.e., the probable existence of a recurrent pathway to MNCs via an interneuron, and the importance of aminergic and peptidergic input in regulating the electrical activity of MNCs.
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References
Bargmann W (1965) Über Synapsen im endokrinen System. Nova Acta Leopoldina, NF 30:199–206
Barker JL, Crayton JW, Nicoll RA (1971) Noradrenaline and acetylcholine responses of supraoptic neurosecretory cells. J Physiol 218:19–32
Bennett T, Burnstock G, Cobb JLS, Malmfors T (1970) An ultrastructural and histochemical study of the short-term effects of 6-hydroxidopamine on adrenergic nerves in the domestic fowl. Br J Pharmacol 38:802–809
Blähser S, Dubois MP (1980) Immunocytochemical demonstration of met-enkephalin in the central nervous system of the domestic fowl. Cell Tissue Res 213:53–68
De Robertis EDP (1964) Histophysiology of sinapses and neurosecretion. In: Alexander D, Bacq ZM (eds) International series of monographs on pure and applied biology. Modern trends in physiological sciences. Vol 20. Pergamon Press, Oxford
Dogterom J, Buijs RM (1980) Vasopressin and oxytocin distribution in rat brain: Radioimmunoassay and immunocytochemical studies. In: Ajmone Marson C, Traczyk WZ (eds) Neuropeptides and neural transmission. Raven Press, New York, pp 307–314
Dreifuss JJ, Kelly JS (1972) The activity of identified supraoptic neurones and their responses to acetylcholine applied by iontophoresis. J Physiol 220:105–118
Eneström S (1967) Nucleus supraopticus: a morphological and experimental study in the rat. Acta Pathol Microbiol Scand 186:1–99
Follénius E (1962) Etude comparative de la citologie fine du noyau preoptique (NPO) et du noyau lateral (NLT) chez la Truite (Salmo irideus Gibb.) et chez la Perche (Perca fluvialis L.). Comparison des deux types de neurosecretion. Gen Comp Endocrinol 3:66–85
Fuxe K, Ljunggren L (1965) Cellular localization of monoamines in the upper brain stem of the pigeon. J Comp Neurol 125:355–382
Gargiulo G, Nisticó G (1978) Time course of 5,6-dihydroxytryptamine neurotoxic effects on fowl diencephalon and upper brain stem monoaminergic pathways. J Anat 126:261–274
Gérard-Ivanoff A (1974) Histogenèse des neurones aminergiques du diencephale chez le Poulet, Gallus gallus. Arch Anat Hist Embryol Norm et Exp 57:115–134
Gray EG (1959) Axosomatic and axodendritic synapses of the cerebral cortex: an electron microscopic study. J Anat (Lond) 93:420–432
Gray EG (1971) The fine structural characterization of different types of synapses. Progr Brain Res 34:149–160
Hartwig HG, Oksche A (1975) Aminergic innervation of anterior hypothalamic nuclei in the house sparrow (Passer domesticus) and in the laboratory mouse. Gen Comp Endocrinol 29:243 (Abstract)
Hayward JN (1975) Neural control of the posterior pituitary. Ann Rev Physiol 37:191–210
Ifft JD, McCarthy L (1974) Somatic spines in the supraoptic nucleus of the rat hypothalamus. Cell Tissue Res 148:203–211
Klein MJ, Porte A, Stutinsky F (1968) Contacts synaptiques axo-axoniques dans les noyaux supraoptiques et paraventriculaires du rat et de la souris. C R Acad Sci (Paris) 267:1007–1009
Koizumi K, Ishikawa T, McBrooks C (1973) The existence of facilitatory axon collaterals in neurosecretory cells of the hypothalamus. Brain Res 63:408–413
Krisch B (1980) Immunocytochemistry of neuroendocrine systems. Vasopressin, somatostatin, luliberin. Progr Histochem Cytochem 13:1–163
Kurosomi K, Yukitake Y (1977) Morphological and morphometric studies on the terminal boutons on the neurosecretory cells of the rat paraventricular nucleus. Arch Histol Jpn 40 Suppl:293–302
Legait H (1959) Contribution a l'étude morphologique et expérimentale du système hypothalamo-neurohypophysaire de la Poule Rhode Island. Thèse Louvain. Soc d'Impression Typographiques. Nancy
Lérànth CS, Zaborszky L, Marton J, Palkovits M (1975) Quantitative studies on the supraoptic nucleus in the rat. I Synaptic organization. Exp Brain Res 22:509–523
McNeill TH, Abel JH Jr, Kozlowski GP (1975) Correlations between brain catecholamines, neurosecretion and serum corticoid levels in osmotically stressed mallard ducks (Anas platyrhynchos). Cell Tissue Res 161:277–283
Mikami S, Kawamura K, Oksche A, Farner DS (1976) The fine structure of the hypothalamic secretory neurons of the White-crowned Sparrow, Zonotrichia leucophrys gambelii (Passeriformes: Fringillidae). II Magnocellular and parvocellular nuclei of the rostral hypothalamus. Cell Tissue Res 165:415–434
Moss RL, Urban I, Cross BA (1972) Microelectrophoresis of cholinergic and aminergic drugs on paraventricular neurons. Am J Physiol 223:310–318
Negoro H, Holland RC (1972) Inhibition of unit activity in the hypothalamic paraventricular nucleus following antidromic activation. Brain Res 42:385–402
Nicoll RA, Barker JL (1971) The pharmacology of recurrent inhibition in the supraoptic neurosecretory system. Brain Res 35:501–511
Oehmke HJ, Priedkalns J, Vaupel von Harnack M, Oksche A (1969) Fluoreszenz- und elektronmikroskopische Untersuchungen am Zwischenhirn-Hypophysensystem von Passer domesticus. Z Zellforsch 95:109–133
Palkovits M, Brownstein MJ (1978) Concentrations of the neurotransmitters in the supraoptic and paraventricular nuclei of the rat. In: Bargmann W, Oksche A, Polenov A, Scharrer B (eds) Neurosecretion and neuroendocrine activity. Evolution, Structure, Function. Springer-Verlag, Berlin Heidelberg New York, pp 250–255
Panzica GC (1980) The preoptic area of the domestic fowl. II Ultrastructure of medial preoptic area. Cell Tissue Res 210:85–94
Panzica GC, Cantino D (1981) Synaptic terminals in the suprachiasmatic nucleus of the chicken. J Submicr Cytol 13:79–83
Panzica GC, Viglietti Panzica C, Contenti E (1980) Development of neuronal and synaptic architecture of the paraventricular nucleus in the chick embryo. Gen Comp Endocrinol 40:355 (Abstract)
Pelletier (1979) Immunohistochemical localization of hypothalamic hormones and other peptides in the central nervous system. In: Collu R, Burbeau A, Ducharme J, Rochefort J-G (eds) Central nervous system effects of hypothalamic hormones and other peptides. Raven Press, New York, pp 331–344
Peterson RP (1965) Synapses in the rat supraoptic nucleus. Anat Rec 151:399 (Abstract)
Polenov AL, Senchik JI (1966) Synapses on neurosecretory cells of the supraoptic nucleus in white mice. Nature 211:1423–1424
Priedkalns J, Oksche A (1969) Ultrastructure of synaptic terminals in nucleus infundibularis and nucleus supraopticus of Passer domesticus. Z Zellforsch 98:135–147
Prymak EKh, Hajós F (1970) Synapses on the supraoptic neurosecretory neurons of the rat: an electron microscopic study. Acta Morphol Acad Sci Hung 18:55–62
Renaud LP (1978) Neurophysiological organization of the endocrine hypothalamus. In: Reichlin S, Baldessarini RJ, Martin JB (eds) The hypothalamus. Raven Press, New York, pp 269–301
Sharp PJ, Follett BK (1968) The distribution of monoamines in the hypothalamus of the Japanese quail Coturnix coturnix japonica. Z Zellforsch 90:245–262
Sharp PJ, Follett BK (1970) The adrenergic supply within the avian hypothalamus. In: Bargmann W, Scharrer B (eds) Aspects of neuroendocrinology. Springer-Verlag, Berlin Heidelberg New York, pp 95–103
Sterba G (1978) Oxytocinergic extrahypothalamic neurosecretory system of the vertebrates and memory process. In: Bargmann W, Oksche A, Polenov A, Scharrer B (eds) Springer-Verlag, Berlin Heidelberg New York, pp 293–299
Swanson LW, Sawchenko PE (1980) Paraventricular nucleus: A site for the integration of neuroendocrine and autonomic mechanisms. Neuroendocrinology 31:410–417
Viglietti Panzica C (1979) Fine structure of the paraventricular magnocellular neurons in the domestic fowl. Boll Soc Ital Biol Sper 55:1909–1914
Viglietti Panzica C, Panzica GC (1981a) The hypothalamic magnocellular system in the domestic fowl. A Golgi and electron microscopic study. Cell Tissue Res 215:113–131
Viglietti Panzica C, Panzica GC (1981b) Neuronal typology and synaptic organization of the hypothalamic magnocellular system in the fowl. 6th Europ Anatom Congress, Hamburg Acta Anatomica, 111:155 (Abstract)
Viglietti Panzica C, Bessé MC (1982) The organum vascolosum laminae terminalis of the domestic fowl. A Golgi and ultrastructural study. Anat Anz, in press
Vincent JD, Arnaud E (1975) Vasopressin as a neurotransmitter in the central nervous system, some evidence from the supraoptic neurosecretory system. Progress Brain Res 42:57–66
Watkins WB (1980) Presence of adrenocorticotropin and β-endorphin immunoreactivities in the magnocellular neurosecretory system of the rat hypothalamus. Cell Tissue Res 207:65–80
Woods WH, Holland RC, Powell EW (1969) Connections of cerebral structures functioning in neurohypophyseal hormone release. Brain Res 12:26–46
Wurtman RJ (1970) Neuroendocrine transducer cells in mammals. In: Schmitt FO (ed) The neuroscience: 2nd study program. Rockfeller University Press, New York, pp 530–538
Yagi K, Azuma T, Matsuda K (1966) Neurosecretory cell capable of conducting impulse in rats. Science 154:778–779
Yamada S, Mikami S (1981) Immunocytochemical localization of neurotensin-containing neurons in the hypothalamus of the Japanese quail Coturnix coturnix japonica. Cell Tissue Res 218:29–39
Zàborsky L, Lérànth CS, Makara GB, Palkovits M (1975) Quantitative studies on the supraoptic nucleus in the rat. II Afferent fiber connections. Exp Brain Res 22:525–540
Zambrano D (1968) The effect of nialamide and L-DOPA on the supraoptic nucleus of the rat. Neuroendocrinology 3:99–106
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This work was partly supported by a CNR grant (n. 81.00377.04)
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Panzica, G.C., Viglietti-Panzica, C. & Contenti, E. Synaptology of neurosecretory cells in the nucleus paraventricularis of the domestic fowl. Cell Tissue Res. 227, 79–92 (1982). https://doi.org/10.1007/BF00206333
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DOI: https://doi.org/10.1007/BF00206333