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Annexins: calcium-binding proteins of multi-functional importance?

Medical Microbiology and Immunology volume 180, pages 109–126 (1991)Cite this article

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Reference

  1. Al-Alawi N, Fleckman P, Resing KA, Ahn NG (1988) Differentiation specific expression of lipocortin I and endonexin I in rat epidermis and cultured keratinocytes. J cell Biol 107:253A

  2. Ali SM, Geisow MJ, Bugoyne RD (1989) A role for calpactin in calcium-dependent exocytosis in adrenal chromaffin cells. Nature 340:313–315

    Google Scholar 

  3. Bastian BC, Römisch J, Pâques E-P, Burg G (1991) Lipocortins and phospholipases: new aspects in the physiology of the action of glucocorticosteroids. Hautarzt (in press)

  4. Bevers EM, Comfurius P, Zwaal RFA (1983) Changes in membrane phospholipids during platelet activation. Biochim Biophys Acta 57:57–66

    Google Scholar 

  5. Blackwood RA, Ernst JD (1990) Characterization of Ca2+-dependent phospholipid binding, vesicle aggregation and membrane fusion by annexins. Biochem J 266:195–200

    Google Scholar 

  6. Blackwell GJ, Carnuccio R, DiRosa M, Flower RJ, Parente L, Persico P (1980) Macrocortin: a poly-peptide causing the anti-phospholipase effect of glucocorticoids. Nature 287:147–149

    Google Scholar 

  7. Blackwell GJ, Carnuccio R, DiRosa M, Flower RJ, Langham CSJ, Parente L, Persico P, Russel-Smith NC, Stone D (1982) Glucocorticoids induce the formation and release of anti-inflammatory and anti-phospholipase proteins into the peritoneal cavity of the rat. Br J Pharmacol 76:185–194

    Google Scholar 

  8. Bohn H (1979) Placental and pregnancy proteins. In: Lehmann FG (ed) Carcinoembryonic proteins, vol 1. Elsevier/North Holland Biomedical Press, Amsterdam 289–299

    Google Scholar 

  9. Bohn H (1982) New soluble placental tissue proteins. Ric Clin Lab 12:221–230

    Google Scholar 

  10. Bolton C, Elderfield AJ, Flower RJ (1990) The detection of lipocortins 1, 2 and 5 in central nervous system tissues from Lewis rats with acute experimental allergic encephalomyelitis. J. Neuroimmunol 29:173–181

    Google Scholar 

  11. Boustead CM, Smallwood M, Small H, Bowles DJ, Walker JH (1989) Identification of calcium-dependent phospholipid-binding proteins in higher plant cells. FEBS Lett 244:456–460

    Google Scholar 

  12. Burgoyne RD, Geisow MJ (1989) The annexin family of calcium-binding proteins. Cell Calcium 10:1–10

    Google Scholar 

  13. Burgoyne RD, Morgan A (1990) The control of free arachidonic acid levels. Trends Biochem Sci 15:365–366

    Google Scholar 

  14. Burn AL, Magenzo K, Shirvan A, Srivastava M, Rojas E, Alijani MR, Pollard HB (1989) Calcium channel activity of purified human synexin and structure of the human synexin gene. Proc Natl Acad Sci USA 86:3798–3802

    Google Scholar 

  15. Camussi G, Tetta C, Bussolino F, Baglioni C (1990) Antiinflammatory peptides (antiflammins) inhibit synthesis of platelet-activating factor, neutrophil aggregation and chemotaxis, and intradermal inflammatory reactions. J Exp Med 171:913–927

    Google Scholar 

  16. Carraway KL, Liu Y, Puett D, Carraway KL, Carothers, Carraway CA (1987) Phenothiazine binding by a homolog of calpactin, the pp60src tyrosine kinase substrate. FASEB J 87:46–50

    Google Scholar 

  17. Cartwright PH, Ilehyshyn A, Ilderton I, Yardley HJ (1988) Modulation of phospholipase A2 activity in extracts of lesion-free psoriatic epidermis by alkaline phosphatase and a protein phosphatase inhibitor. Br J Dermatol 118:333–338

    Google Scholar 

  18. Chap H, Comfurius P, Bevers EM, Fauvel J, Vicendo P, Blazy LD, Zwaal RFA (1988) Biochem Biophys Res Commun 150:972–978

    Google Scholar 

  19. Christmas P, Callaway J, Fallon J, Jones J, Haigier HT (1991) Selective secretion of annexin 1, a protein without a signal sequence, by the human prostate gland. J Biol Chem 266:2499–2507

    Google Scholar 

  20. Cirino G, Flower RJ (1987) The inhibitory effect of lipocortin on eicosanoid synthesis is dependent on Ca2+-ions. Br J Pharmacol 92:521

    Google Scholar 

  21. Cirino G, Peers SH, Flower RJ, Browning JL, Pepinsky RB (1989) Human recombinant lipocortin I has acute local anti-inflammatory properties in the rat paw edema test. Proc Natl Acad Sci USA 86:3428–3432

    Google Scholar 

  22. Coméra C, Rothhut B, Cavadore JCV, Vilgrain I, Cochet C, Chambaz E, Russo-Marie F (1989) Further characterization of four lipocortins from human peripheral blood mononuclear cells. J Cell Biochem 40:361–370

    Google Scholar 

  23. Coméra C, Rothhut B, Russo-Marie F (1990) Identification and characterization of phospholipase A2 inhibitory proteins in human mononuclear cells. Eur J Biochem 188:139–146

    Google Scholar 

  24. Creutz CE, Pazoles CJ, Pollard HB (1978) Identification and purification of an adrenal medullary protein (synexin) that causes calcium-dependent aggregation of isolated chromaffin granules. J Biol Chem 253:2858–2866

    Google Scholar 

  25. Creutz CE, Dowling LG, Sando JJ, Villar-Palasi C, Whipple JH, Zaks WJ (1983) Characterization of the chromobindins. J Biol Chem 258:14664–14674

    Google Scholar 

  26. Creutz CE, Zaks WJ, Hamman HC, Cranes, Martin WH, Gould KL, Oddie KM, Parsons SJ (1987) Identification of chromaffin granule-binding proteins. J Biol Chem 262:1860–1868

    Google Scholar 

  27. Crompton MR, Moss SE, Crumpton MJ (1988) Diversity in the lipocortin/calpactin family. Cell 55:1–3

    Google Scholar 

  28. Crumpton JJ, Dedman JR (1990) Protein terminology tangle. Nature 345:212

    Google Scholar 

  29. Davidson FF, Dennis EA (1989) Biological relevance of lipocortins and related proteins as inhibitors of phospholipase A2. Biochem Pharmacol 38:3645–3652

    Google Scholar 

  30. Davies P, Bailey PJ, Goldenberg MM (1984) The role of arachidonic acid oxygenation products in pain and inflammation. Annu Rev Immunol 2:335–357

    Google Scholar 

  31. Dennis EA, Davidson FF (1990) Phospholipase A2 and lipocortin effects. Prog Clin Biol Res 349:47–54

    Google Scholar 

  32. Diaz-Munoz M, Hamilton SL (1990) Modulation of Ca2+ release channel activity from sarcoplasmic reticulum by annexin VI (67-kDa calcimedin). J Biol Chem 265:15894–15899

    Google Scholar 

  33. DiRosa M, Flower RJ, Hirata F, Parente L, Russo-Marie F (1984) Nomenclature announcement: anti-phospholipase proteins. Prostaglandins 28:441

    Google Scholar 

  34. DiRosa M, Sautebin L, Carnuccio R (1988) Phospholipase A2 and lipocortins, antiphospholipase proteins. Methods Enzymol 163:23–31

    Google Scholar 

  35. Ernst JD, Hoye E, Blackwood RA (1989) Use of a novel strategy for the preparation and characterization of an antipeptide antibody capable of recognizing members of the annexin family. Biochem Biophys Res Commun 161:959–964

    Google Scholar 

  36. Errasfa M, Russo-Marie F (1989) A purified lipocortin shares the anti-inflammatory effect of glucocorticosteroids in vivo in mice. Br J Pharmacol 97:1051–1058

    Google Scholar 

  37. Errasfa M, Bachelet M, Russo-Marie F (1988) Inhibition of phospholipase A2 activity of guinea-pig alveolar macrophages by lipocortin-like proteins purified from mice lung. Biochem Biophys Res Commun 153:1267–1270

    Google Scholar 

  38. Evans RM (1988) The steroid and thyroid receptor superfamily. Science 240:889–895

    Google Scholar 

  39. Fava RA, Cohen S (1984) Isolation of a calcium-dependent 35-kDa substrate for the epidermal growth factor receptor/kinase from A-431 cells. J Biol Chem 259:2636–2645

    Google Scholar 

  40. Flaherty MJ, West S, Heimark RL, Fujikawa K, Tait JF (1990) Placental anticoagulant protein-I: measurement in extracellular fluids and cells of the hemostatic system. J Lab Clin Med 115:174–181

    Google Scholar 

  41. Flower RJ (1988) Lipocortin and the mechanism of action of anti-inflammatory steroids. Ann Clin Biochem 25:6s-7

    Google Scholar 

  42. Flower RJ (1988) Lipocortin and the mechanism of action of the glucocorticoids. Br J Pharmacol 94:987–1015

    Google Scholar 

  43. Flower RJ, Wood JN, Parente L (1984) Macrocortin and the mechanism of action of the glucocorticoids. Adv Inflammation Res 7:61–70

    Google Scholar 

  44. Fradin A, Rothhut B, Poincelot-Canton B, Errasfa M, Russo-Marie F (1988) Inhibition of eicosanoid and PAF formation by dexamethasone in rat inflammatory polymorphonuclear neutrophils may implicate lipocortin‘s’. Biochem Biophys Acta 963:248–257

    Google Scholar 

  45. Frohlich M, Motté P, Galvin K, Takahashi H, Wands J, Ozturk M (1990) Enhanced expression of the protein kinase substrate p 36 in human hepatocellular carcinoma. Mol Cell Biol 10:3216–3223

    Google Scholar 

  46. Geisow MJ, Walker JH, Boustead C, Taylor W (1987) Localization and structure of novel calcium-regulated phospholipid-binding proteins. Biochem Soc Trans 15:800–802

    Google Scholar 

  47. Gerke V (1989) Consensus peptide antibodies reveal a widespread occurrence of Ca2+/lipid-binding proteins of the annexin family. FEBS Lett 258:259–262

    Google Scholar 

  48. Gerke V (1991) Identification of a homologue for annexin VII (synexin) in Dictyostelium discoideum. J Biol Chem 266:1697–1700

    Google Scholar 

  49. Gerke V, Weber K (1985) Calcium-dependent comformational changes in the 36-kDa subunit of intestinal protein I related to the cellular 36-kDa target of rous sarcoma virus tyrosine kinase. J Biol Chem 260:1686–1695

    Google Scholar 

  50. Giambanco I, Pula G, Bianchi R, Donato R (1990) Interaction of two brain annexins, CaBP33 and CaBP37, with membrane-skeleton proteins. FEBS Lett 267:171–175

    Google Scholar 

  51. Glenney JR (1986) Two related but distinct forms of the M r 36,000 tyrosine kinase substrate (calpactin) that interact with phospholipid and actin in a Ca2+-dependent manner. Proc Natl Acad Sci USA 83:4258–4262

    Google Scholar 

  52. Glenney JR Jr (1987) Calpactins: calcium-regulated membrane-skeletal proteins. Biochem Soc Trans 15:798–800

    Google Scholar 

  53. Glenney JR, Tack BF (1985) Amino-terminal sequence of p36 and associated p10: identification of the site of tyrosine phosphorylation and homology with S-100. Proc Natl Acad Sci USA 82:7884–7888

    Google Scholar 

  54. Göcze PM, Szabo BG, Than GN, Krommer KF, Csaba IF, Bohn H (1988) Placental protein 4 as a possible marker for monitoring of tumours. Med Sci Res 16:407–408

    Google Scholar 

  55. Goldberg M, Feinberg J, Rainteau D, Lecolle S, Dedman JR, Glenney JR, Weinman S (1989) Differential localization of calmodulin, the 67-kDa calcimedin and calpactin II in secretory ameloblasts. Connect Tissue Res 22:157–164

    Google Scholar 

  56. Goulding NJ, Guyre PM (1988) Impairment of erythrocyte-antibody rosette formation by human lipocortin I on human leucocytes. Biochem Soc Trans 16:730–731

    Google Scholar 

  57. Goulding NJ, Smith SF, Godolphin JL, Tetley TD, Roberts CM, Guz A, Flower RJ (1989) Quantification of lipocortin 1 in bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis. Br J Pharmacol 97:426

    Google Scholar 

  58. Goulding NJ, Podgorski MR, Hall ND, Flower RJ, Browning JL, Pepinsky RB, Maddison PJ (1989) Autoantibodies to recombinant lipocortin-1 in rheumatoid arthritis and systemic lupus erythemnatosus. Ann Rheum Dis 48:843–850

    Google Scholar 

  59. Goulding NJ, Godolphin JL, Sharland PR, Peers SH, Sampson M, Maddison PJ, Flower RJ (1990) Anti-inflammatory lipocortin 1 production by peripheral blood leucocytes in response to hydrocortisone. Lancet 335:1416–1418

    Google Scholar 

  60. Grundmann U, Abel KJ, Bohn H, Löbermann H, Lottspeich, Küpper H (1988) Characterization of cDNA encoding human placental anticoagulant protein (PP4): homology with the lipocortin family. Proc Natl Acad Sci USA 85:3708–3712

    Google Scholar 

  61. Gurpide E, Markiewicz L, Schatz F, Hirata F (1986) Lipocortin output by human endometrium in vitro. J Clin Endocrinol Metab 63:162–166

    Google Scholar 

  62. Haigler HT, Schlaepfer DD, Burgess WH (1987) Characterization of lipocortin I and an immunologically unrelated 33-kDa protein as epidermal growth factor receptor/kinase substrates and phospholipase A2 inhibitors. J Biol Chem 262:6921–6930

    Google Scholar 

  63. Haigler HT, Fitch JM, Jones JM, Schlaepfer DD (1989) Two lipocortin-like proteins, endonexin II and anchorin CII, may be alternate splices of the same gene. Trends Biochem Sci 14:48–50

    Google Scholar 

  64. Hattori T, Hoffman T, Hirata F (1983) Differentiation of a histiocytic lymphoma cell line by lipmodulin, a phospholipase inhibitory protein. Biochem Biophys Res Commun 111:551–559

    Google Scholar 

  65. Hattori T, Hirata F, Hoffman T, Hizuta A, Herberman RB (1983) Inhibition of human natural killer (NK) activity and antibody dependent cellular cytotoxicity (ADCC) by lipomodulin, a phospholipase inhibitory protein. J Immunol 131:662–665

    Google Scholar 

  66. Hauptmann R, Maurer-Fogy I, Kryster E, Bodo G, Andree H, Reutelingsperger CPM (1989) Vascular anticoagulant beta: a novel Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Eur J Biochem 185:63–71

    Google Scholar 

  67. Hirata F (1981) The regulation of lipomodulin, a phospholipase inhibitory protein, in rabbit neutrophils by phosphorylation. J Biol Chem 256:7730–7733

    Google Scholar 

  68. Hirata F (1984) Roles of lipomodulin: a phospholipase inhibitory protein in immunoregulation. Adv Inflammation Res 7:71–78

    Google Scholar 

  69. Hirata F (1989) The role of lipocortins in cellular function as a second messenger of glucocorticoids. In: Anti-inflammatory steroid action; basic and clinical aspects. Academic Press, New York, pp 67–95

    Google Scholar 

  70. Hirata F, Iwata M (1983) Role of lipomodulin, a phospholipase inhibitory protein, in immunoregulation by thymocytes. J Immunol 130:1930–1936

    Google Scholar 

  71. Hirata F, Schiffmann E, Venkatasubramanian K, Salomon D, Axelrod J (1980) A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids. Proc Natl Acad Sci USA 77:2533–2536

    Google Scholar 

  72. Hirata F, Del Carmine R, Nelson CA, Axelrod J, Schiffmann E, Warabi A, De Blas AL, Nirenberg M, Manganiello V, Vaughan M, Kumagai S, Green I, Decker JL, Steinberg AD (1981) Presence of autoantibody for phospholipase inhibitory protein, lipomodulin, in patients with rheumatic diseases. Proc Natl Acad Sci USA 78:3190–3194

    Google Scholar 

  73. Hoffmann GE, Guder WG (1989) Serum phospholipase. A catalytic activity. Klin Wochenschr 67:144–148

    Google Scholar 

  74. Huber R, Römisch J, Pâques E-P (1990) The crystal and molecular structure of human annexin V, an anticoagulant protein that binds to calcium and membrane. EMBO J 9:3867–3874

    Google Scholar 

  75. Huber R, Schneider M, Mayr I, Römisch J, Pâques E-P (1990) The calcium binding sites in human annexin V by crystal structure analysis at 2.0 A resolution. FEBS Lett 275:15–21

    Google Scholar 

  76. Huebner K, Cannizzaro LA, Frey AZ, Hecht BK, Hecht F, Croce CM, Wallner BP (1988) Chromosomal localization of the human genes for lipocortin I and lipocortin II. Oncogene Res 2:299–310

    Google Scholar 

  77. Ialenti A, Doyle PM, Hardy GN, Simpkin DSE, DiRosa M (1990) Anti-inflammatory effects of vasocortin and nonapeptide fragments of uteroglobin and lipocortin I (antiflammins). Agents Actions 29:48–49

    Google Scholar 

  78. Isacke CM, Lindberg RA, Hunter T (1989) Synthesis of p36 and p35 is increased when U937 cells differentiate but expression is not inducible by glucocorticoids. Mol Cell Biol 9:232–240

    Google Scholar 

  79. Iwasaki A, Suda M, Nakao H, Nayoya T, Saino Y, Arai K, Mizoguchi T, Sato F, Yoshizaki H, Hirata M, Miyata T, Shidara Y, Murata M, Maki M (1987) Structure and expression of cDNA for an inhibitor of blood coagulation isolated from human placenta: a new lipocortin-like protein. J Biochem 102:1261–1273

    Google Scholar 

  80. Iwasaki A, Suda M, Watanabe M, Nakao H, Hattori Y, Nagoya T, Saino Y, Shidara Y, Maki M (1989) Structure and expression of cDNA calphobindin II, a human placental coagulation inhibitor. J Biochem 106:43–49

    Google Scholar 

  81. Johnson PA, Perin MS, Reynolds GA, Wasserman SA, Südhof TC (1990) Two novel annexins from Drosophila melanogaster. J Biol Chem 265:11382–11388

    Google Scholar 

  82. Kaetzel MA, Dedman JR (1989) Affinity purified site-directed antibody recognizes the entire annexin protein family. Biochem Biophys Res Commun 160:1233–1237

    Google Scholar 

  83. Kaetzel MA, Hazarika P, Dedman JR (1989) Differential tissue expression of three 35kDa annexin calcium-dependent phospholipid-binding proteins. J Biol Chem 264:14463–14470

    Google Scholar 

  84. Kaplan R, Jaye M, Burgess WH, Schlaepfer DD, Haigler HT (1988) Cloning and expression of cDNA for human endonexin II, a Ca2+ and phospholipid binding protein. J Biol Chem 263:8037–8043

    Google Scholar 

  85. Kenton P, Johnson PM, Webb PD (1989) The phosphorylation of p68, a calcium-binding protein asssociated with the human syncytiotrophoblast submembranous cytoskeleton, is modulated by growth factors, activators of protein kinase C and cyclic AMP. Biochem Biophys Acta 1014:271–281

    Google Scholar 

  86. Kitajima Y, Owada MK, Yaoita H (1989) Differentiation and translocation of lipocortin I from cytoplasm to plasma membrane in human keratinocytes. Cell Struct Funct 14:939

    Google Scholar 

  87. Kitajima Y, Owada MK, Yaoita H (1990) Translocation of lipocortin I from cytoplasm to plasma membrane in psoriatic keratinocytes and in low to normal Ca2+-grown keratinocytes. J Invest Dermatol 4:542

    Google Scholar 

  88. Klee CB (1988) Ca+-dependent phospholipid-(and membrane-) binding proteins. Biochemistry 27:6645–6653

    Google Scholar 

  89. Kretsinger RH, Creutz CE (1986) Consensus in exocytosis. Nature 320:573

    Google Scholar 

  90. Machoczek K, Fischer M, Söling HD (1989) Lipocortin I and II inhibit phosphoinositide-and polyphosphoinositide-specific phospholipase C. FEBS Lett 251:207–212

    Google Scholar 

  91. Marciniak E (1984) Physiology of antithrombin III. Ric Clin Lab 14:475–483

    Google Scholar 

  92. Maridonneau-Parini I, Errasfa M, Russo-Marie F (1989) Inhibition of O2—generation by dexamethasone is mimicked by lipocortin I in alveolar macrophages. J Clin Invest 83:1936–1940

    Google Scholar 

  93. Märki F, Pfeilschifter J, Rink H, Wiesenberg I (1990) ‘Antiflammins’: two nonapeptide fragments of uteroglobin and lipocortin I have no phospholipase A2-inhibitory and anti-inflammatory activity. FEBS Lett 264:171–175

    Google Scholar 

  94. Martin F, Derancourt J, Capony JP, Watrin A, Cavadore JC (1988) A 36 kDa monomeric protein and its complex with a 10 kDa protein both isolated from bovine aorta are calpactin-like proteins that differ in their Ca2+-dependent calmodulin-binding and actin-severing properties. Biochem J 251:777–785

    Google Scholar 

  95. Mauch C, van der Mark K, Helle O, Mollenhauer J, Pfäffle M, Krieg T (1988) A defective cell surface collagen-binding protein in dermatosparactic sheep fibroblasts. J Cell Biol 106:205–211

    Google Scholar 

  96. Maurer-Fogy I, Reutelingsperger CPM, Pieters J, Bodo G, Stratowa C, Hauptmann R (1988) Cloning and expression of cDNA for human vascular anti-coagulant, a Ca2+-dependent phospholipid-binding protein. Eur J Biochem 174:585–592

    Google Scholar 

  97. Miele L, Cordella-Miele E, Facchiano A, Mukherjee AB (1988) Novel anti-inflammatory peptides from the region of highest similarity between uteroglobin and lipocortin I. Nature 335:726–730

    Google Scholar 

  98. Mohri M, Spriggs DR, Kufe D (1990) Effects of lipopolysaccharide on phospholipase A2 activity and tumor necrosis factor expression in HL-60 cells. J Immunol 144:2678–2682

    Google Scholar 

  99. Moore PB (1988) Calcimedin, calelectrin: correlation of relatedness. Biochem Biophys Res Commun 156:193–198

    Google Scholar 

  100. Morse SS, Moore PB (1988) 67 K calcimedin (67 kDa) is distinct from p67 calelectrin and lymphocyte 68 kDa Ca2+-binding protein. Biochem J 251:171–174

    Google Scholar 

  101. Müller-Berghaus G (1989) Pathophysiologic and biochemical events in disseminated intravascular coagulation: disregulation of procoagulant and anticoagulant pathways. Semin Thromb Hemost 15:58–87

    Google Scholar 

  102. Munn TZ, Mues GI (1986) Human lipocortin similar to ras gene products. Nature 322:314–315

    Google Scholar 

  103. Owens RJ, Crumpton MJ (1984) Isolation and characterization of a novel 68000-M r Ca2+-binding protein of lymphocyte plasma membrane. Biochem J 219:309–316

    Google Scholar 

  104. Owens RJ, Gallagher CJ, Crumpton MJ (1984) Cellular distribution of p68, a new calcium-binding protein from lymphocytes. EMBO J 3:945–952

    Google Scholar 

  105. Parente L, Flower RJ (1985) Hydrocortisone and macrocortin inhibit the zymosan-induced release of lyso-PAF from rat peritoneal leucocytes. Life Sci 36:1225–1231

    Google Scholar 

  106. Parente L, Becherucci C, Perretti M, Solito E, Mudridge CL, Galeotti G, Raugei M, Sanso M (1990) Are the lipocortins the second messengers of the anti-inflammatory action of glucocorticoids? Prog Clin Biol Res 349:55–68

    Google Scholar 

  107. Pepinsky RB, Sinclair LK (1986) Epidermal growth factor-dependent phosphorylation of lipocortin. Nature 321:81–84

    Google Scholar 

  108. Pepinsky RB, Tizard R, Mattaliano RJ, Sinclair LK, Miller GT, Browning JL, Chow EP, Burne C, Huang KS, Pratt D (1988) Five distinct calcium and phospholipid binding proteins share homology with lipocortin. J Biol Chem 263:10799–10811

    Google Scholar 

  109. Perretti M, Becherucci C, Mugridge KC, Solito E, Silvestri S, Parente L (1991) A novel anti-inflammatory peptide from human lipocortin 5. Br J Pharmacol 103 (in press)

  110. Pollard HB, Burns AL, Rojas E, Schaepfer DD, Haigler HT, Brocklehurst K (1989) Purification and biochemical assay of synexin and of the homologous calcium-dependent membrane-binding proteins, endonexin II and lipocortin I. Methods Cell Biol 31:207–227

    Google Scholar 

  111. Powell MA, Glenney JR (1987) Regulation of calpactin I phospholipid binding by calpactin I light-chain binding and phosphorylation by p60v-src. Biochem J 247:321–328

    Google Scholar 

  112. Reutelingsperger CPM (1989) Das vaskuläre Antikoagulans (VAC), ein Annexin mit einem neuen Mechanismus der Antikoagulation. Haemostasis 9:157–166

    Google Scholar 

  113. Reutelingsperger CPM, Hornstra G, Hemker HC, (1985) Isolation and partial purification of a novel anticoagulant from arteries of human umbilical cord. Eur J Biochem 151:625–629

    Google Scholar 

  114. Rivers JK, Pudgorski MR, Goulding NJ, Wong E, McGrath A, Flower RJ, Greaves MW (1990) The presence of autoantibody to recombinant lipocortin-I in patients with psoriasis and psoriatic arthritis. Br J Dermatol 123:569–572

    Google Scholar 

  115. Robitzki A, Schröder HC, Ugarkovic D, Gramzow M, Fritsche U, Batel R, Müller EG (1990) cDNA structure and expression of calpactin, a peptide involved in Ca2+-dependent cell aggregation in sponges. Biochem J 271:414–420

    Google Scholar 

  116. Rojas E, Pollard HB, Haigler HT, Parra C, Burns AL (1990) Calcium-activated endonexin II forms calcium channels across acidic phospholipid bilayer membranes. J Biol Chem 265:21207–21215

    Google Scholar 

  117. Römisch J, Heimburger N (1990) Purification and characterization of six annexins from human placenta. Biol Chem Hoppe Seyler 5:383–388

    Google Scholar 

  118. Römisch J, Grote M, Weithmann KU, Heimburger N, Amann E (1990) Annexin proteins PP4 and PP4-X: comparative characterization of biological activities of placental and recombinant proteins. Biochem J 272:223–229

    Google Scholar 

  119. Römisch J, Schorlemmer U, Fickenscher K, Pâques E-P, Heimburger N (1990) Anticoagulant properties of placenta protein 4 (Annexin V). Thromb Res 60:355–366

    Google Scholar 

  120. Römisch J, Schüler E, Pâques E-P, Heimburger N (1990) Hämostase, Fibrinolyse, Proteolyse: Wechselwirkungen mit Entzündungsreaktionen. Behring Inst Res Commun 86:129–145

    Google Scholar 

  121. Römisch J, Diehl KH, Reiner G, Pâques E-P (1991) Activated protein C: anti-thrombotic properties and influence on fibrinolysis in an animal model. Fibrinolysis (in press)

  122. Römisch J, Seiffge D, Reiner G, Pâques E-P, Heimburger N (1991) In vivo anti-thrombotic potency of placenta protein 4 (Annexin V). Thromb Res 61:93–104

    Google Scholar 

  123. Ross TS, Tait JF, Majerus PW (1990) Identity of inositol 1,2 cyclic phosphate 2-phosphohydrolase with lipocortin III. Science 248:604–607

    Google Scholar 

  124. Rothhut B, Russo-Marie F, Wood J, DiRosa M, Flower RJ (1983) Further characterization of the glucocorticoid-induced antiphospholipase protein “renocortin”. Biochem Biophys Res Commun 177:878–884

    Google Scholar 

  125. Russo-Marie F (1990) Glucocorticoid control of eicosanoid synthesis. Semin Nephrol 10:421–429

    Google Scholar 

  126. Sakata T, Iwagami S, Tsuruta Y, Teraoka H, Hojo K, Suzuki S, Sato K, Suzuki R (1990) The role of lipocortin I in macrophage-mediated immunosuppression in tumor-bearing mice. J Immunol 145:387–396

    Google Scholar 

  127. Saris CJM, Tack BF, Kristensen T, Glenney JR Jr, Huter T (1986) The cDNA sequence for the protein-tyrosine kinase substrate p36 (calpactin I heavy chain) reveals a multidomain protein with internal repeats. Cell 46:201–212

    Google Scholar 

  128. Sate EF, Okimasu E, Takahashi R, Masonobu M, Matsuno T, Utsumi K (1988) Lipocortin-like 33-kDa protein of guinea pig neutrophil. Its distribution and stimulation-dependent translocation detected by monoclonal anti-33 kDa protein antibody. Cell Struct Funct 13:89–96

    Google Scholar 

  129. Sato EF, Tanaka Y, Edashige K, Kobuchi H, Morishita S, Sugino YM, Inove M, Utsumi K (1989) Expression of the cDNA encoding lipocortin-like 39-kDa protein of guinea pig neutrophils in yeast. FEBS Lett 255:231–236

    Google Scholar 

  130. Schlaepfer DD, Haigler HT (1988) In vitro protein kinase phosphorylation of placental lipocortin. Biochemistry 27:4253–4258

    Google Scholar 

  131. Schlaepfer DD, Haigler HT (1990) Expression of annexins as a function of cellular growth state. J Cell Biol 111:229–238

    Google Scholar 

  132. Schlaepfer DD, Mehlman T, Burgess WH, Haigler HT (1987) Structural and functional characterization of endonexin II, a calcium- and phospholipid-binding protein. Proc Natl Acad Sci USA 84:6078–6082

    Google Scholar 

  133. Shidara Y (1984) Isolation and purification of placental coagulation inhibitor. Acta Obstet Gynaecol Jpn 36:2583–2592

    Google Scholar 

  134. Shimizu Y, Takabayashi E, Yano S, Saimizu N, Yamata K, Gushima H (1988) Molecular cloning and expression in Excherichia coli of the cDNA coding for rat lipocortin I (calpactin II). Gene 65:141–147

    Google Scholar 

  135. Shirotake S, Inaba N, Ohta Y, Fukazawa I, Takamizawa H, Bohn H (1986) Immunochemical measurement of placental protein 4 in serum. Chem Pharm Bull 34:2191–2195

    Google Scholar 

  136. Smallwood M, Keen JN, Bowless DJ (1990) Purification and practical sequence analysis of plant annexins. Biochem J 270:157–161

    Google Scholar 

  137. Smith SF, Tetley TD, Guz A, Flower RJ (1990) Detection of lipocortin 1 in human lung lavage fluid: lipocortin degradation as a possible proteolytic mechanism in the control of inflammatory mediators and inflammation. Environ Health Perspect 85:135–144

    Google Scholar 

  138. Sobota A, Cusinato F, Luciani S (1990) Identification and purification of calpactins from cardiac muscle and their effect on Na2+/Ca2+ exchange activity. Biochem Biophys Res Commun 172:1067–1072

    Google Scholar 

  139. Sobue K, Kanda K, Miyamoto I, Ilda K, Yahara I, Hirai R, Hiragun A (1989) Comparison of the regional distribution of calspectin (non erythroid spectrin or fodrin), alpha-actinin, vinculin non-erythroic protein 4.1, and calpactin in normal and avian sarcoma virus- or rous sarcoma virus-induced transformed cells. Exp Cell Res 181:256–292

    Google Scholar 

  140. Südhof TC (1984) The calectrins: new and ubiquitous Ca2+-regulated proteins with a possible role in cytotic processes. Biochem Soc Trans 12:972–974

    Google Scholar 

  141. Südhof TC, Slaughter CA, Leznicki I, Barjon P, Reynolds GA (1988) Human 67-kDa calelectrin contains a duplicatin of four repeats found in 35-kDa lipocortins. Proc Natl Acad Sci USA 85:664–668

    Google Scholar 

  142. Tait JF, Sakata M, McMullen BA, Miao CH, Funakoshi T, Hendrickson LE, Fujikawa K (1988) Placental anti-coagulant proteins: isolation and comparative characterization of four members of the Lipocortin family. Biochemistry 27:6268–6276

    Google Scholar 

  143. Tait JF, Gibson D, Fujikawa (1989) Phospholipid binding properties of human placental anticoagulant protein-I, a member of the lipocortin family. J Biol Chem 264:7944–7949

    Google Scholar 

  144. Thiagarajan P, Tait JF (1990) Binding of annexin V/placental anti-coagulant protein I to platelets. J Biol Chem 265:17420–17423

    Google Scholar 

  145. Uede T, Hirata F, Hirashima M, Ishizaka K (1983) Modulation of the biologic activities of IgE-binding factors. J Immunol 130:878–884

    Google Scholar 

  146. Van Binsbergen J, Slotboom AJ, Aarsman AJ, De Haas GH (1989) Synthetic peptide from lipocortin I has no phospholipase A2 inhibitory activity. FEBS Lett 247:293–297

    Google Scholar 

  147. Varticovski L, Chahwala SB, Whitman M, Cantley L, Schindler D, Chow EP, Sinclair LK, Pepinsky RB (1988) Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinses A and C. Biochemistry 27:3682–3690

    Google Scholar 

  148. Verhage HG, Fazleabas AT, Donnelly K (1988) The in vitro synthesis and release of proteins by the human oviduct. Endocrinology 122:1639–1645

    Google Scholar 

  149. Violette SM, King I, Browning JL, Pepinsky RB, Wallner BP, Sartorelli AC (1990) Role of lipocortin I in the glucocorticoid induction of the terminal differentiation of a human squamous carcinoma. J Cell Physiol 142:70–77

    Google Scholar 

  150. Von Gool R, Andree HAM, Hemker HC, Reutelingsperger CPM (1990) Mode of action of annexin V (vascular anti-coagulant alpha), a protein synthesized by the vessel wall. In: Harenberg J, Heene DL, Stehle G, Schettler G (eds) New trends in haemostasis. Springer, Berlin Heidelberg New York, pp 136–151

    Google Scholar 

  151. Walker JH (1982) Isolatin from cholinergic synapses of a protein that binds to membranes in a calcium-dependent manner. J Neurochem 39:815–823

    Google Scholar 

  152. Wallner BP, Mattaliano RJ, Hession C, Cate RL, Tizard R, Sinclair LK, Foeller C, Chow EP, Browning JL, Ramachandran KL, Pepinsky RB (1986) Cloning and expession of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity. Nature 320:77–81

    Google Scholar 

  153. Webb PD, Mahadevan LC (1987) Calcium-dependent binding proteins associated with human placental synctiotrophoblast microvillus cytoskeleton. Biochem Biophys Acta 916:288–297

    Google Scholar 

  154. Weber G, Ferber E (1990) Selective inhibition of phospholipase A2 by different lipocortins. Biol Chem Hoppe Seyler 371:725–731

    Google Scholar 

  155. Weksler BB (1988) Roles for human platelets in inflammation. In: Platelet membrane receptors: molecular biology, immunology, biochemistry and pathology. Alan R. Liss, New York, pp 611–638

    Google Scholar 

  156. Whitehouse BJ (1989) Lipocortins, mediators of the anti-inflammatory actions of corticosteroids? J Endocrinol 123:363–366

    Google Scholar 

  157. William F, Mroczkowski B, Cohen S, Kraft AS (1988) Differentiation of HL-60 cells is associated with an increase in the 35-kDa protein lipocortin I. J Cell Physiol 137:402–410

    Google Scholar 

  158. Woolgav JA, Boustead CM, Walker JH (1990) Characterization of annexins in mammalian brain. J Neurochem 54:62–71

    Google Scholar 

  159. Zaks WJ, Creutz CE (1990) Evaluation of the annexins as potential mediators of membrane fusion in exocytosis. J Bioenerg Biomembr 22:97–119

    Google Scholar 

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    Jürgen Römisch & Eric-P. Pâques

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This publication is dedicated to Prof. N. Heimburger on the occasion of his 65th birthday

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Römisch, J., Pâques, EP. Annexins: calcium-binding proteins of multi-functional importance?. Med Microbiol Immunol 180, 109–126 (1991). https://doi.org/10.1007/BF00206115

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