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A phase I study of intrapleural Corynebacterium parvum after complete resection of bronchogenic carcinoma

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Summary

Corynebacterium parvum (C. parvum) was instilled into the pleural space via the chest tube in 11 patients after curative resection for lung cancer. Doses were escalated from 20–70 mg in approximately every third patient in an attempt to determine the maximum tolerated dose. Fever and chest pain were the only toxicities encountered; severity and duration were not dose-related. Six of seven surgical stage I patients were alive and free of recurrence with a median follow-up of 2 1/2 years. A single patient developed light-chain-producing multiple myeloma 1 year after C. parvum injection.

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Authors and Affiliations

  1. Department of Medicine, Division of Medical Oncology, Albert Einstein College of Medicine, 10461, Bronx, New York, USA

    A. J. Solan, S. E. Vogl, T. Zaravinos & C. Salazar

Authors
  1. A. J. Solan
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  2. S. E. Vogl
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  3. T. Zaravinos
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  4. C. Salazar
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American Cancer Society Clinical Fellow

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Solan, A.J., Vogl, S.E., Zaravinos, T. et al. A phase I study of intrapleural Corynebacterium parvum after complete resection of bronchogenic carcinoma. Cancer Immunol Immunother 8, 263–264 (1980). https://doi.org/10.1007/BF00206045

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  • DOI: https://doi.org/10.1007/BF00206045

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