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Systemic administration of Corynebacterium parvum during sensitization to tumor alloantigen-modified response to rechallenge

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Summary

Intravenous administration of Corynebacterium parvum (C. parvum) to mice during a primary immune response against tumor alloantigens impairs their ability to generate memory cell-mediated cytotoxicity (CMC) in response to an intraperitoneal rechallenge with the same tumor alloantigens. Decreased CMC was observed in spleen and mesenteric lymph nodes, whereas CMC of lymphoid populations from the peritoneal cavity was merely delayed, reaching comparable levels to those found in control animals by day 5. Serum levels of cytotoxic antibody were unaffected, indicating that C. parvum administered during a primary immune response has selective effects on the cytotoxic memory response.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, UCLA School of Medicine, 90024, Los Angeles, California, USA

    J. Zighelboim

  2. Department of Medicine, UCLA School of Medicine, 90024, Los Angeles, California, USA

    R. I. Murahata

Authors
  1. R. I. Murahata
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  2. J. Zighelboim
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Murahata, R.I., Zighelboim, J. Systemic administration of Corynebacterium parvum during sensitization to tumor alloantigen-modified response to rechallenge. Cancer Immunol Immunother 8, 257–261 (1980). https://doi.org/10.1007/BF00206044

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  • DOI: https://doi.org/10.1007/BF00206044

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