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Some biochemical aspects of the protective effect of strontium chloride on γ-irradiated rats

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Abstract

The effect of treatment with SrCl2 (10 mg 100 g−) on rats 15 min prior to whole body γ-irradiation (7.5 Gy) was studied. The hazardous effects of irradiation were greatly corrected in the treated group. The hyperglycemic effect and liver glycogen accumulation in the untreated group decreased to normal level. The enzymatic activities of serum alkaline phosphatase, alanine and aspartate aminotransferases, and lactate dehydrogenase were greatly affected, showing insignificant changes in the treated group of animals. Life span calculated on 50% survival was also significantly elongated by 36.3%. These results show the potentiality of SrCl2 as a radioprotective agent. A proposed mechanism is discussed.

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Authors and Affiliations

  1. Department of Biochemistry, Faculty of Science, Ain Shams University, Cairo, Egypt

    Fawzia A. Fahim, Hamid M. Roshdy, Raafat M. Yousri & Medhat I. Abady

  2. National Centre for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt

    Hamid M. Roshdy, Raafat M. Yousri & Medhat I. Abady

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  1. Fawzia A. Fahim
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  2. Hamid M. Roshdy
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  3. Raafat M. Yousri
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  4. Medhat I. Abady
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Fahim, F.A., Roshdy, H.M., Yousri, R.M. et al. Some biochemical aspects of the protective effect of strontium chloride on γ-irradiated rats. Biometals 6, 163–170 (1993). https://doi.org/10.1007/BF00205855

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  • DOI: https://doi.org/10.1007/BF00205855

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