Skip to main content


Log in

Single amino acid substitution in the V3 domain of CD4 is responsible for OKT4 epitope deficiency

  • Brief Communication
  • Published:
Immunogenetics Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.


  • Aozasa, M., Amino, N., Iwatani, Y., Tamaki, H., Watanabe, Y., Sato, H., Hochito, K., Umeda, K., Gunji, T., Yoshizawa, T., Iyama, S., and Miyai, K.: Familial OKT4 epitope deficiency: studies on antigen density and lymphocyte function. Clin Immunol Immunopathol 37: 48–55, 1985

    Google Scholar 

  • Arthos, J., Deen, K. C., Chaikin, M. A., Fornwald, J. A., Sathe, G., Sattentau, Q. J., Clapham, P. R., Weiss, R. A., McDougal, J. S., Pietropaolo, C., Axel, R., Truneh, A., Maddon, P. J., and Sweet, R.: Identification of the residues in human CD4 critical for the binding of HIV. Cell 57: 469–481, 1989

    Google Scholar 

  • Bach, M.-A., Phan-Dinh-Tuy, F., Bach, J.-F., Wallach, D., Biddison, W. E., Sharrow, S. O., Goldstein, G., and Kung, P. C.: Unusual phenotypes of human T cells as measured by OKT4 and related monoclonals. J Immunol 127: 980–982, 1981

    Google Scholar 

  • Casey, T. T., Posey, D. H., and McCurley, T. L.: OKT4 epitope deficiency in significant proportions of the black population. Arch Pathol Lab Med 110: 702–704, 1986

    Google Scholar 

  • Dalgleish, A. G., Beverley, P. C. L., Clapham, P. R., Crawford, D.H., Greaves, M. F., and Weiss, R. A.: The CD4(T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature 312: 763–765, 1986

    Google Scholar 

  • Falcao, R. P. and Ismaed, S. J.: Absence of OKT4 antigen epitope: Report of a case in a Brazilian population. J Clin Lab Immunol 22: 205–207, 1987

    Google Scholar 

  • Fuller, T. C., Trevithick, J. E., Fuller, A. A., Colvin, R. B., Cosimi, A. B., and Kung, P. C.: Antigenic polymorphism of the T4 differentiation antigen expressed on human T helper/inducer lymphocytes. Hum Immunol 9: 98–102, 1984

    Google Scholar 

  • Hoxie, J. A., Flaherty, L. E., Haggarty, B. S., and Rackowski, J. E.: Infection of T4 lymphocytes by HTLV-III does not require expression of the OKT4 epitope. J Immunol 136: 361–363, 1986

    Google Scholar 

  • Joffe, M. I. and Rabson, A. R.: Absence of OKT-4 positive lymphocytes in black African subjects. Cell Immunol 84: 453–457, 1984

    Google Scholar 

  • Klatzmann, D., Champagne, E., Chamaret, S., Gruest, J., Guetard, D., Hercend, T., Gluckman, J.-C., and Montagnier, L.: T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature 312: 767–782, 1986

    Google Scholar 

  • Kramer, W., Drutsa, M., Jansen, H. W., Kramer, B., Pflugfelder, M., and Fritz, H. J.: The gapped duplex DNA approach to oligonucleotide-directed mutation construction. Nucleic Acids Res 12: 9441–9456, 1984

    Google Scholar 

  • Lamarre, D., Ashkenazi, A., Fleury, S., Smith, D. H., Sekaly, R.-P., and Capon, D. J.: The MHC-binding and gp120-binding functions of CD4 are separable. Science 245: 743–746, 1989

    Google Scholar 

  • Levy, D. S., Church, J. A., and Richards, W.: OKT4 epitope deficiency as a cause of reduced “helper” T cells in children at risk for human immunodeficiency virus infection. Pediatr 113: 79–82, 1988

    Google Scholar 

  • Maddon, P. J., Littman, D. R., Godfrey, M., Maddon, D. E., Chess, L., and Axel, R.: The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family. Cell 42: 93–104, 1985

    CAS  PubMed  Google Scholar 

  • Rudd, C. E., Anderson, P., Morimoto, C., Steuli, M., and Schlossman, S. F.: Molecular interactions, T-cell subsets and a role of the CD4/CD8: p56lck complex in human T-cell activation. Immunol Rev 111: 225–266, 1989

    Google Scholar 

  • Stohl, W.: Deficient OKT4 epitope on helper T cells in a patient with SLE: confusion with AIDS. New Engl J Med 310: 1531, 1984

    Google Scholar 

  • Stohl, W. and Kunkel, H. G.: Heterogeneity in expression of the T4 epitope in black individuals. Scand J Immunol 20: 273–278, 1984

    Google Scholar 

Download references

Author information

Authors and Affiliations


Additional information

Address correspondence and offprint requests to: H. Nakauchi.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tokito, S., Kishi, S., Yamamoto, R. et al. Single amino acid substitution in the V3 domain of CD4 is responsible for OKT4 epitope deficiency. Immunogenetics 34, 208–210 (1991).

Download citation

  • Received:

  • Issue Date:

  • DOI: