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Augmentation of natural cell activity in tumor-bearing and normal mice by MVE-2

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Summary

Mice bearing advanced Lewis lung carcinoma were found to have significantly decreased natural killer (NK) cell activity in spleen and blood. The same pattern of lowered spontaneous NK cell activity was observed in nude mice with advanced human colon carcinoma LS 174 and in C3H mammary tumor virus-positive mice that spontaneously developed mammary adenocarcinomas. Maleic anhydride divinyl ether (MVE-2) usually augments NK cell activity in normal mice. We found that the lower level of spontaneous NK cell activity in tumor-bearing mice could be boosted by a single injection of MVE-2; however, this response was much weaker than that observed in age-matched normal mice. Multiple treatments with MVE-2 which are known to induce hyporesponsiveness to further augmentation of NK cell activity in spleen and blood of normal mice, also produced NK cell hyporesponsiveness in the spleen, bone marrow, and blood of tumor-bearing mice.

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Authors and Affiliations

  1. Preclinical Screening Laboratory, Program Resources, Inc., NCI-FCRF, and Biological Therapeutic Branchs, Biological Response Modifiers Program, National Cancer Institute, Frederick Cancer Research Facility, 21701, Frederick, Maryland, USA

    Wladyslaw Budzynski, Michael Chirigos & Eilene Gruys

Authors
  1. Wladyslaw Budzynski
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  2. Michael Chirigos
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  3. Eilene Gruys
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Wladyslaw Budzynski is a guest researcher in the Preclinical Screening Laboratory from the Institute of Immunology and Experimental Therapy, Czerska Street 12, Wroclaw, Poland

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Budzynski, W., Chirigos, M. & Gruys, E. Augmentation of natural cell activity in tumor-bearing and normal mice by MVE-2. Cancer Immunol Immunother 24, 253–258 (1987). https://doi.org/10.1007/BF00205639

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  • DOI: https://doi.org/10.1007/BF00205639

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