Skip to main content

Advertisement

SpringerLink
Log in

Canine lymphoma-associated antigens defined by murine monoclonal antibodies

  • Original Articles
  • Published:
Cancer Immunology, Immunotherapy Aims and scope Submit manuscript

Summary

Lymphoma in dogs resembles human non-Hodgkin's lymphoma in pathological presentation, immunophenotype, and response to therapy, thus representing a good model for comparative studies with human disease. Monoclonal antibodies (MAbs) were derived from mice immunized with a dog lymphoma cell line. Three MAbs were selected for further application in immunophenotyping and immunotherapy. The binding specificities, antigen characterization, and isotypes for these MAbs are described.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Akiyama Y, Lubeck MD, Steplewski Z, Koprowski H (1984) Induction of mouse IgG2a and IgG3 dependent cellular cytotoxicity in human monocytic cells (U937) by human interferon. Cancer Res 44:5127–5131

    Google Scholar 

  2. Applebaum FR, Sale GE, Storb R, Charrier K, Deeg H-J, Graham T, Wulff JC (1984) Phenotyping of canine lymphoma with monoclonal antibodies, directed to cell surface antigens: classification, morphology, clinical presentation and response to chemotherapy. Hemato Oncol 2:151–168

    Google Scholar 

  3. Atkinson BF, Ernst CS, Herlyn M, Steplewski Z, Sears HF, Koprowski H (1982) Gastrointestinal cancer-associated antigen in immunoperoxidase assay. Cancer Res 42:4820–4823

    Google Scholar 

  4. Bayum A (1964) Separation of white blood cells. Nature 204:793–794

    Google Scholar 

  5. Bloomfield CD, Gajl-Peczalska KJ, Frizzera G, Kersey JH, Goldman AI (1979) Clinical utility of lymphocyte surface markers combined with the Luker-Collina histologic classifications in adult lymphoma. N Engl J Med 301:512–518

    Google Scholar 

  6. Carter RF, Valli VEO, Lumsden JH (1986) The cytology, histology and prevalence of cell types in canine lymphoma classified according to the National Cancer Institute Working Formulation. Can J Vet Res 50:154–164

    Google Scholar 

  7. Deeg H-J, Wulff CJ, DeRose S, Sale GE, Braun M, Brown MA, Springmeyer SC, Martin PJ, Storb R (1982) Unusual distribution of Ia-like antigens on canine lymphocytes. Immunogenetics 16:445–457

    CAS  PubMed  Google Scholar 

  8. Dorn CR, Taylor DO, Hibbard HH (1967) Epizootiologic characteristics of canine and feline leukemia and lymphoma. Am J Vet Res 28:993–1001

    Google Scholar 

  9. Engvall E, Perlmann P (1971) Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. Immunochemistry 8:871–874

    Google Scholar 

  10. Hansen JA, Martin PJ, Nowinski RC (1980) Monoclonal antibodies identifying a novel T-cell antigen and Ia antigens of human lymphocytes. Immunogenetics 10:247–260

    Google Scholar 

  11. Hansson GC, Karlsson K-A, Larson G, McKibbin JM, Blaszczyk M, Herlyn M, Steplewski Z, Koprowski H (1983) Mouse monoclonal antibodies against cancer cell lines with specificities for blood group and related antigens. J Biol Chem 258:4091–4097

    Google Scholar 

  12. Herlyn D, Koprowsky H (1982) IgG2a monoclonal antibodies inhibit human growth through interaction with effector cells. Proc Natl Acad Sci USA 79:4761–4765

    Google Scholar 

  13. Hester JP, Kellogg RM, Mulzet AP, Kruger VR, McCredie KB, Freireich EJ (1979) Principles of blood separation and component extraction in a disposable continuous-flow singlestage channel. Blood 54:254–266

    Google Scholar 

  14. Hsu S-M, Raine L (1981) Protein A, avidin and biotin in immunohistochemistry. J Histochem Cytochem 29:1349–1353

    Google Scholar 

  15. Jeglum KA (1983) Chemotherapy of lymphosarcoma. In: Kirk RW (ed) Kirk's current therapy — small animal practice VIII, WB Saunders, Philadelphia, Pa.

    Google Scholar 

  16. Karlsson K-A, Samuelsson DE, Steen GO (1973) The sphingolipid composition of bovine kidney, cortex, medulla, and papilla. Biochim Biophys Acta 316:317–335

    Google Scholar 

  17. Kearney JF, Radburch A, Liesegan B, Rajewsky K (1979) A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines. J Immunol 123:1548–1550

    Google Scholar 

  18. Kohler G, Milstein C (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495–496

    CAS  PubMed  Google Scholar 

  19. Koprowski H, Gerhard W, Croce CM (1977) Production of antibodies against influenza virus by somatic cell hybrids between mouse myeloma and primed spleen cells. Proc Natl Acad Sci USA 74:2985–2988

    Google Scholar 

  20. Koprowski H, Steplewski Z, Herlyn D, Herlyn M (1978) Study of antibodies against human melanoma produced by somatic cell hybrids. Proc Natl Acad Sci USA 75:3405–3409

    Google Scholar 

  21. Krawiec DR, Muscoplat CC (1984) Development and characterization of a hybridoma-derived antibody (Aby 1A1) with specificity to canine lymphocytes and peripheral T thymocytes. Am J Vet Res 45:491–198

    Google Scholar 

  22. Kung PC, Goldstein G, Reinherz E, Schlossman SD (1979) Monoclonal antibodies defining distinctive human T cell surface antigens. Sceince 206:347–349

    Google Scholar 

  23. Ladiges WC, Durkopp N, Urban C, Wulff JC, Storb R (1984) Monoclonal antibodies to canine cell surface antigens. A comparison of screening assays. Hybridoma 3:387–390

    Google Scholar 

  24. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680–685

    PubMed  Google Scholar 

  25. Lehtonen OP, Viljanen MK (1980) Antigen attachment in ELISA. J Immunol Methods 34:61–70

    Google Scholar 

  26. Macewen EC, Brown NO, Patnaik AK (1981) Cyclic combination chemotherapy of canine lymphosarcoma. J Am Vet Med Assoc 178:1178–1181

    Google Scholar 

  27. McKenzie JL, Fabre JW (1981) Studies with a monoclonal antibody on the distribution of Thy-1 in the lymphoid and extracellular connective tissue of the dog. Transplantation 31:275–282

    Google Scholar 

  28. Mitchell KF, Fuhrer JP, Steplewski Z, Koprowski H (1981) Structural characterization of the “melanoma-specific” antigen detected by monoclonal antibody 691 I5NU-4-B Mol. Immunology 18:207–218

    Google Scholar 

  29. Reinherz EL, Kung PC, Goldstein G, Schlossman SF (1979) Separation of functional subsets of human T cells by a monoclonal antibody. Proc Natl Acad Sci USA 76:4061–4065

    Google Scholar 

  30. Shulman M, Wilde CD, Kohler G (1978) A better cell line for making hybridomas secreting specific antibodies. Nature 276:269–270

    Google Scholar 

  31. Spira G, Bargellesi A, Teillaud J, Scharff M (1984) The identification of monoclonal class switch variants by sib selection and an ELISA assay. J Immunol Methods 74:307–315

    Google Scholar 

  32. Steplewski Z, Herlyn D, Maul G, Koprowski H (1983) Hypothesis: macrophages as effector cells for human tumor destruction mediated by monoclonal antibody. Hybridoma 2:1–5

    Google Scholar 

  33. Stocker JW, Garotta G, Hausmann B, Trucco M, Ceppellini R (1979) Separation of human B cells bearing HLA-DR antigens using a monoclonal antibody rosetting method. Tissue Antigens 13:212–222

    Google Scholar 

  34. The Non-Hodgkin's Lymphoma Pathologic Classification Project (1982) National Cancer Institute sponsored study of classifications of non-Hodgkin's lymphomas. Summary and description of a working formulation for clinical usage. Cancer 49:2112–2135

    Google Scholar 

  35. Towbin H, Staehlein T, Gordon J (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some application. Proc Natl Acad Sci USA 76:4350–4354

    CAS  PubMed  Google Scholar 

  36. Trucco MM, Stocker JW, Ceppellini R (1978) Monoclonal antibodies against human lymphocyte antigens. Nature 273:666–668

    Google Scholar 

  37. Wulff JC, Deeg H-J, Storb R (1982) A monoclonal antibody (DT-2) recognizing canine T-lymphocytes. Transplantation 33:616–620

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Wistar Institute, 36th at Spruce, 19104, Philadelphia, PA, USA

    Zenon Steplewski & Carlos Rosales

  2. School of Veterinary Medicine, University of Pennsylvania, 38th at Spruce, 19104, Philadelphia, PA, USA

    K. Ann Jeglum & Nancy Weintraub

Authors
  1. Zenon Steplewski
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. Ann Jeglum
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Carlos Rosales
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Nancy Weintraub
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported by NCI grant CA-10815

Rights and permissions

Reprints and permissions

About this article

Cite this article

Steplewski, Z., Jeglum, K.A., Rosales, C. et al. Canine lymphoma-associated antigens defined by murine monoclonal antibodies. Cancer Immunol Immunother 24, 197–201 (1987). https://doi.org/10.1007/BF00205629

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00205629

Keywords

Search

Navigation