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Tumor immunity and autoimmunity produced by injection of antigens modified by adsorbed virus

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Summary

C3H/Bi mice were injected repeatedly with isolated plasma membranes carrying adsorbed paramyxovirus antigens. The membranes prepared from a syngeneic ascitic lymphoma induced by the Gross leukemia virus by themselves stimulated little immune response but after treatment with concentrated virus, in some experiments they produced tumor transplant resistance and usually autoimmunity, as demonstrated by serological reactions and appearance of fatal autoimmune disease. Cytotoxic and complement-fixing antibodies against uninfected lymphoma and splenocytes were demonstrated. Autohemolysin related to an unidentified heterophile antigen also appeared. The relationship of autoimmunity, in timing and dose response, to tumor immunity is considered.

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Abbreviations

NDV:

Newcastle disease virus

Siv:

Sendai virus

PBS:

phosphate buffered saline

HA:

hemagglutination

NCM:

normal untreated lymphoma crude membrane

IP:

intraperitoneal

CFA:

complete Freund's adjuvant

CF:

complement fixation

References

  1. Almquist SJP, Eaton MD (1978) Cell mediated immunity in mice immunized with modified syngeneic Gross lymphoma antigen. Cell Immunol 37:383–389

    Google Scholar 

  2. Atkinson PH, Summers DF (1971) Purification and properties of HeLa cell plasma membranes. J Biol Chem 246:5162–5175

    Google Scholar 

  3. Baechtel FS, Prager MD (1977) Anti-thymocyte autoimmunity in BALB/c mice accompanying immunization to a syngeneic lymphoma. J Immunol 118:175–179

    Google Scholar 

  4. Eaton MD (1979) Role of envelope proteins of Paramyxovirus in the modification of cell membrane antigens. Arch Virol 61:327–336

    Google Scholar 

  5. Eaton MD (1980) Autoimmunity induced by syngeneic splenocyte membranes carrying irreversibly adsorbed Paramyxovirus. Infect Immun 27:855–861

    Google Scholar 

  6. Eaton MD, Almquist SJP (1975) Antibody response of syngeneic mice to membrane antigens from NDV infected lymphoma. Proc Soc Exp Biol Med 148:1090–1094

    Google Scholar 

  7. Eaton MD, Almquist SJP (1977) Autoimmunity induced by injection of virus-modified cell membrane antigen in syngeneic mice. Infect Immun 15:322–328

    Google Scholar 

  8. Eaton MD, Scala AR (1970) Species source of complement in viral immune and other cytolytic reactions. Proc Soc Exp Biol Med 133:615–619

    Google Scholar 

  9. Eaton MD, Levinthal JD, Scala AR (1967) Contribution of antiviral immunity to oncolysis by Newcastle disease virus in a murine lymphoma. J Natl Cancer Inst 39:1089–1097

    Google Scholar 

  10. Eaton MD, Heller JA, Scala AR (1973) Enhancement of lymphoma cell immunogenicity by infection with nononcogenic virus. Cancer Res 33:3293–3298

    Google Scholar 

  11. Kano K, Fjelde A, Milgrom F (1977) Paul-Bunnell antigen in lymphoma and leukemia spleen. J Immunol 119:945–949

    Google Scholar 

  12. Kimura Y, Ito Y, Nagata I, Yoshii S, Maeno K, Matsumoto T (1976) Surface antigens on HeLa cells persistently infected with HJV (Sendai virus). Arch Virol 51:275–283

    Google Scholar 

  13. Kuzumaki H, Moriuchi T, Kodama T, Kobayashi H (1976) Xenogenization of rat erythroid cells by lymphatic leukemia virus: Its role in induction of autoimmune hemolytic anemia. J Immunol 117:1250–1255

    Google Scholar 

  14. Neff JM, Enders JF (1968) Poliovirus replication and cytophathogenicity in monolayer hamster cell culture fused with β-propiolactone inactivated Sendai virus. Proc Soc Exp Biol Med 127:260–267

    Google Scholar 

  15. Phillips SM, Hirsh MS, Andre-Schwartz J, Solnick G, Black P, Schwartz RS, Merrill JP, Carpenter CB (1975) Cellular immunity in the mouse. V. Further studies on leukemia virus activation in allogeneic reactions of mice: Stimulation parameters. Cellular Immunol 15:169–180

    Google Scholar 

  16. Takeichi N, Kuzumaki Kodama T, Sendo F, Hosokawa M, Kobayashi H (1972) Runting syndrome in rats inoculated with Friend virus. Cancer Res 32:445–449

    Google Scholar 

  17. Welsh RM Jr, Zinkernagel RM, Hallenbeck LA (1979) Cytotoxic cells induced during lymphocytic choriomeningitis virus infection of mice. II. Specificities of the natural killer cells. J Immunol 122:475–481

    Google Scholar 

  18. Wise KS (1977) Vesicular stomatitis virus infected L1210 murine leukemia cells: Increased immunogenicity and altered surface antigens. J Natl Cancer Inst 58:83–90

    Google Scholar 

  19. Zinkernagel RM, Doherty PC (1972) Major transplantation antigens, virus, and specificity of surveillance T cells. The “altered self” hypothesis. Contemp Top Immunobiol 7:179–189

    Google Scholar 

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Authors and Affiliations

  1. Department of Medical Microbiology, Stanford University School of Medicine, 94305, Stanford, California, USA

    Monroe D. Eaton

  2. Syntex Laboratories, 94304, Palo Alto, California, USA

    Susan J. P. Almquist

Authors
  1. Monroe D. Eaton
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  2. Susan J. P. Almquist
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Eaton, M.D., Almquist, S.J.P. Tumor immunity and autoimmunity produced by injection of antigens modified by adsorbed virus. Cancer Immunol Immunother 9, 199–205 (1980). https://doi.org/10.1007/BF00205626

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  • DOI: https://doi.org/10.1007/BF00205626

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