Summary
The inhibitory effect of interferon on colony formation of myeloma stem cells in two layer plasma clot-soft agar cultures was studied. Human lymphoblast interferon inhibited in therapeutically attainable concentrations myeloma stem cell proliferation in 50% and human fibroblast interferon in 23% of the 14 myeloma patients in whom in vitro colony formation could be achieved. In interferon-sensitive patients the numbers of myeloma stem cell clusters and colonies were decreased to 34.4%–54.9% of control cultures. In addition, maturation of myeloma stem cells in differentiated plasma cells was reduced by interferon in most of these cases.
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Ludwig, H., Swetly, P. In vitro inhibitory effect of interferon on colony formation of myeloma stem cells. Cancer Immunol Immunother 9, 139–143 (1980). https://doi.org/10.1007/BF00205617
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DOI: https://doi.org/10.1007/BF00205617