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Lysis of autologous tumor cells by blood lymphocytes activated in autologous mixed lymphocyte tumor cell culture — No correlation with the postsurgical clinical course

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Summary

Mixed lymphocyte tumor cell cultures (MLTC) were initiated with cells collected at the time of surgery from 62 patients with the following diagnoses: 12 squamous cell carcinoma, 14 adenocarcinoma of the lung, 17 osteosarcomas, and 16 soft tissue sarcomas. The lytic effect generated against autologous tumor cells was tested on the 7th day. These patients had been part of previous evaluation, which revealed that the lysis of autologous tumor cells by freshly collected lymphocytes correlated with the postsurgical clinical course. Patients with long survival exhibited autotumor lysis without previous activation. Blood lymphocytes of about half of the primarily nonreactive patients were stimulated for lytic function in MLTC. However, this parameter showed no correlation with the clinical course.

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Authors and Affiliations

  1. Department of Tumor Biology, Karolinska Institute, S-10401, Stockholm, Sweden

    Farkas Vánky & Eva Klein

  2. Department of Radiumhemmet, Karolinska Hospital, S-10401, Stockholm, Sweden

    Farkas Vánky

  3. Department of Tumor Pathology, Karolinska Hospital, S-10401, Stockholm, Sweden

    Jan Willems

  4. Department of Thoracic Surgery, Karolinska Hospital, S-10401, Stockholm, Sweden

    Kim Böök, Torbjörn Ivert & Árpád Péterffy

  5. Department of Orthopedic Surgery, Karolinska Hospital, S-10401, Stockholm, Sweden

    Ulf Nilsonne & Andris Kreicbergs

Authors
  1. Farkas Vánky
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  2. Eva Klein
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  3. Jan Willems
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  4. Kim Böök
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  5. Torbjörn Ivert
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  6. Árpád Péterffy
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  7. Ulf Nilsonne
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  8. Andris Kreicbergs
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Vánky, F., Klein, E., Willems, J. et al. Lysis of autologous tumor cells by blood lymphocytes activated in autologous mixed lymphocyte tumor cell culture — No correlation with the postsurgical clinical course. Cancer Immunol Immunother 24, 180–183 (1987). https://doi.org/10.1007/BF00205598

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  • DOI: https://doi.org/10.1007/BF00205598

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