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Combined treatment of advanced malignant melanoma with coumarin and cimetidine

A phase II study

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Summary

Immunostimulant therapy with coumarin and cimetidine was evaluated in 17 patients with advanced malignant melanoma. Induction therapy with coumarin 100 mg daily was given for 8 weeks, whereupon cimetidine 1000 mg daily was added. No patients had been previously treated with cytotoxic drugs, and all patients had a good performance status. In 16 patients progressive disease was observed, and only 1 patient experienced no change in condition, lasting 30 weeks. We conclude that treatment with this schedule of coumarin and cimetidine is without effect in advanced malignant melanoma.

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Authors and Affiliations

  1. Dept. of Oncology ONA, The Finsen Institute, 49, Strandboulevarden, DK-2100, Copenhagen 0, Denmark

    Lise Pedersen, Carsten Rose & Eyvind Langvad

Authors
  1. Lise Pedersen
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  2. Carsten Rose
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  3. Eyvind Langvad
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Pedersen, L., Rose, C. & Langvad, E. Combined treatment of advanced malignant melanoma with coumarin and cimetidine. Cancer Immunol Immunother 24, 178–179 (1987). https://doi.org/10.1007/BF00205597

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  • DOI: https://doi.org/10.1007/BF00205597

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