Summary
This investigation used three syngeneic C3H/He mammary cacinomas with different immunologic characteristics to compare lymphoid hyperplasia during the progressive growth of immunogenic and nonimmunogenic tumor implants. The effect of immunosuppressive total-body pre-irradiation on the growth of implants of the same immunogenic and nonimmunogenic tumors was also studied. The results showed that the degree of lymphoid hyperplasia did not reflect the immunogenicity or nonimmunogenicity of the implanted tumors, and that tumor growth enhancement by total-body pre-irradiation was also unrelated to the immunogenicity of the implant.
On the basis of these observations it is concluded that neither lymphoid hyperplasia in normal hosts nor growth enhancement in immunosuppressed hosts is a reliable in vivo test for tumor-specific transplantation immunogens.
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Vaage, J. Lack of relationship of transplantation immunogenicity in C3H/He mammary carcinomas, with lymphoid hyperplasia and radiation-induced growth enhancement. Cancer Immunol Immunother 6, 185–189 (1979). https://doi.org/10.1007/BF00205545
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DOI: https://doi.org/10.1007/BF00205545