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Defective interleukin-1 production by monocytes from patients with malignant disease

Interferon increases IL-1 production

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Summary

Interleukin-1 (IL-1) production by monocytes of patients with various forms of malignant disease was measured after activating the cells with either lipopolysaccharide or malignant K562 cells. Monocytes from all the patients with large tumour masses, including 10 patients with hepatocellular carcinoma, produced considerably less IL-1 than controls or patients with small tumour burdens. After treating control or patient monocytes with human leucocyte interferon for 1 h prior to activation, IL-1 production was markedly improved. Depressed IL-1 production is, therefore, a further aberration in mononuclear function observed in patients with cancer.

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Authors and Affiliations

  1. South African Medical Research Council Human Cellular Immunology Unit, School of Pathology of the University of the Witwatersrand, Johannesburg, South Africa

    Jean Herman, Michael C. Kew & Arthur R. Rabson

  2. S.A.I.M.R., P.O. Box 1038, 2000, Johannesburg, South Africa

    Jean Herman, Michael C. Kew & Arthur R. Rabson

Authors
  1. Jean Herman
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  2. Michael C. Kew
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  3. Arthur R. Rabson
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Supported in part by grants from the South African Medical Research Council, the National Cancer Association of South Africa and the South African Chamber of Mines

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Herman, J., Kew, M.C. & Rabson, A.R. Defective interleukin-1 production by monocytes from patients with malignant disease. Cancer Immunol Immunother 16, 182–185 (1984). https://doi.org/10.1007/BF00205426

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  • DOI: https://doi.org/10.1007/BF00205426

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