Summary
The polymorphism of properdin factor B (Bf, C3 proactivator) in a population sample from Hessen, Germany has been investigated by agarose gel electrophoresis and immunofixation. In 522 unrelated individuals seven different phenotypes were observed and the following allele frequencies calculated: BfS=0.7998, BfF=0.1772, BfS0.7=0.0163 and BfF1=0.0077. Investigations of 100 families with 198 children and 30 mother-child combinations support the assumed autosomal codominant way of inheritance.
Zusammenfassung
Der Polymorphismus des Properdin-Faktor B (Bf, C3-Proaktivator) wurde an einer Bevölkerungsstichprobe aus Hessen mittels Agarosegelelektrophorese und Immunofixation untersucht. Bei 522 Personen wurden sieben verschiedene Phänotypen beobachtet und die folgenden Allelfrequenzen berechnet: BfS=0,7998, BfF=0,1772, BfS0,7=0,0163 und BfF1=0,0077. Untersuchungen an 100 Familien mit 198 Kindern und 30 Mutter-Kind-Kombinationen bestätigen den angenommenen autosomal kodominanten Vererbungsmodus.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Albert, E. D., Rittner, C., Grosse-Wilde, H., Netzel, B., Scholz, S.: Recombination Frequency and Linkage Disequilibrium between HL-A and Bf. Histocompatibility Testing 1975. Copenhagen: Munksgaard 1975
Albert, E. D., Rittner, C., Scholz, S., Kuntz, B., Mickey, M. R.: Three-Point Association of HLA-A, B, Bf Haplotypes Deduced in 200 Parents of 100 Families. Scand. J. Immun. 6, 459–464 (1977)
Allen, F. H.: Linkage of HL-A and GBG. Vox Sang. 27, 382–384 (1974)
Allen, F. H., cit.: Jersild, C., Rubinstein, P., Day, N. K.: The HLA System and Inherited Deficiencies of the Complement System. Transplant. Rev. 32, 43–71 (1976)
Alper, C. A., Boenisch, T., Watson, L.: Genetic Polymorphism in Human Glycine-Rich Beta Glycoprotein. J. exp. Med. 135, 60–80 (1972)
Bender, K., Mayerová, A., Frank, R., Hiller, C., Wienker, T.: Haplotype Analysis of the Linkage Group HLA-A: HLA-B: Bf and Its Bearing on the Interpretation of the Linkage Disequilibrium. Hum. Genet. 36, 191–196 (1977)
Hauptmann, G., Tongio, M. M., Mayer, S.: Bf Polymorphism: Study of a New Variant (F 0.55). Hum. Genet. 33, 275–278 (1976)
Hauptmann, G., Tongio, M. M., Mayer, S.: La liaison génétique HLA-Complément. Rev. Franç. Transf. Immunohemat. 20, 19–22 (1977)
Hauptmann, G., Wertheimer, E., Tongio, M. M., Mayer, S.: Bf Polymorphism: Another Variant (S 0.8). Hum. Genet. 36, 109–111 (1977a)
Kühnl, P.: Zur Populationsgenetik des Bf-Systems (Properdinfaktor B). 7th Int. Congr. Soc. Forensic Haematogenetics, Hamburg 1977 (in press)
Kühnl, P., Seidl, S., Spielmann, W.: Untersuchungen zur Koppelung von HLA, Bf und GLO. 7th Int. Congr. Soc. Forensic Haematogenetics, Hamburg 1977 (in press)
Mauff, G., Hummel, K., Pulverer, G.: Properdin Factor B (Glycine-rich beta-Glycoprotein or C3 Proactivator)-Polymorphism: Genetic and Biochemical Aspects-First Application to Paternity Cases. Z. Immun. Forsch. 150, 327–338 (1975)
Mauff, G., Gauchel, F. D., Hitzeroth, H. W.: Polymorphism of Properdin Factor B in South African Negroid, Indian and Colored Populations. Hum. Genet. 33, 319–322 (1976)1
Mauff, G., Hauptmann, G., Hitzeroth, H. W., Gauchel, F., Scherz, R.: The Nomenclature of Properdin Factor B Allotypes. Cambridge, England: EMBO Workshop (1977)
Olaisen, B., Teisberg, P., Gedde-Dahl, T. Jr., Thorsby, E.: The Bf Locus in the HLA Region of Chromosome 6: Linkage and Association Studies. Humangenetik 30, 291–296 (1975)
Race, R. R., Sanger, R.: Blood Groups in Man. p. 481. Oxford: Blackwell 1975
Rittner, C., Grosse-Wilde, H., Rittner, B., Netzel, B., Scholz, S., Lorenz, H., Albert, E. D.: Linkage Group HL-A-MLC-Bf (Properdin Factor B). The Site of the Bf Locus at the Immunogenetic Linkage Group on Chromosome 6. Humangenetik 27, 173–183 (1975)
Scherz, R., Pflugshaupt, R., Bütler, R.: Genetic Polymorphism of Glycine-Rich Beta-Glycoprotein in the Swiss and Italian Populations. Hum. Hered. 27, 143–146 (1977)
Teisberg, P.: High voltage agarose gel electrophoresis in the study of C3 polymorphism. Vox. Sang. 19, 47–56 (1970)
Walther, C. H.: Zum Polymorphismus des Properdinsystems (Bf) im Haupthistokompatibilitätskomplex (HHK) des Menschen. Med. Inaug.-Dissertation. Universität Frankfurt/M., 1977
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kühnl, P., Spielmann, W. Properdin factor B-polymorphism in the population of Hessen, Germany. Z Rechtsmed 81, 125–131 (1978). https://doi.org/10.1007/BF00203872
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF00203872