Summary
In the present work we studied the levels of 5-HT in the pericardial fluid of 160 cadavers according to cause of death; such as myocardial infarction, violent asphyxia, pulmonary embolism, infections, bronchopulmonary diseases, traumatic and hemorrhagic diseases in the CNS, and multiple traumatism. We did not find significant differences in the various causes of death.
A complementary study of 20 dead dogs having suffered induced shock, either hemorrhagic or septic, was made. In both series we studied the serum levels of 5-HT and the following parameters: systolic and diastolic arterial pressures, central venous pressure, hematocrit value, pH value, total proteins, albumin, PO2, and PCO2.
We found the significant correlation (r=0.828, P<0.01) only between 5-HT serum levels and the systolic arterial pressure in the hemorrhagic shock.
Zusammenfassung
In der Pericardflüssigkeit von 160 Leichen mit unterschiedlichen Todesursachen (Herzinfarkt, Ersticken, Lungenembolie, Infektionen, Lungenentzündung, traumatisch-hämorrhagische Erkrankungen des ZNS, Polytrauma etc.) wurde die Konzentration von 5-Hydroxytryptamin bestimmt. Bezüglich der Todesursachen wurden keine signifikanten Konzentrationsunterschiede gefunden.
In einer experimentellen Untersuchung an 20 Hunden, die mittels hämorrhagischem oder septischem Schock getötet wurden, wurden neben 5-Hydroxytryptamin im Serum noch die folgenden Parameter gemessen: systolischer und diastolischer Blutdruck, zentraler Venendruck, Hämatokrit, pH, Gesamt-Serum-Protein, Albumin, PO2 und PCO2. Hierbei konnte nur eine signifikante Korrelation (r=0.828, P<0.01) zwischen der 5-Hydroxytryptamin-Serum-Konzentration und dem systolisch-arteriellen Blutdruck beim hämorrhagischen Schock festgestellt werden.
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Luna, A., Villanueva, E., Hernandez-Cueto, C. et al. Study of 5-hydroxytryptamine (serotonin) in pericardial fluid in different causes of death (II.). Z Rechtsmed 89, 227–236 (1983). https://doi.org/10.1007/BF00203726
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DOI: https://doi.org/10.1007/BF00203726