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Biological Cybernetics

, Volume 64, Issue 1, pp 33–39 | Cite as

A model of the mechanisms of long-term potentiation in the hippocampus

  • T. Kitajima
  • K. Hara
Article

Abstract

Long-Term Potentiation (LTP) in the hippocampus has been considered to be a phenomenon closely related to learning and memory in the brain. In this paper, an integrated model of LTP is constructed based on hypotheses about both the mechanism of LTP induction and that of LTP maintenance, that is, the NMDA-receptor channel, protein phosphorylation and protein turnover. The validity of the model is discussed based on the results of computer simulations.

Keywords

Computer Simulation Protein Phosphorylation Protein Turnover 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • T. Kitajima
    • 1
  • K. Hara
    • 1
  1. 1.Faculty of EngineeringYamagata UniversityYamagataJapan

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