Abstract
Isobutylmethylxanthine (IBMX) suspended in 0.5% hydroxypropyl methylcellulose has been shown to enhance the reduction in intraocular pressure (IOP) induced by epinephrine and norepinephrine in rabbits and beagles. In the present study, the effects of two soluble forms of IBMX, i.e. the ethylenediamine salt (IBMXED) and IBMX bound to cyclodextrin in saline (IBMXCD), were studied in rabbits. When used alone, 1% IBMX-ED did not affect the 10P, but the hypotensive response to 0.1 % epinephrine was enhanced dose-dependently by combination of the catecholarnine with IBMXED. Although 1 % IBMX-CD applied alone also failed to influence the IOP, the hypotensive response to epinephrine, dipivalyl epinephrine and norepinephrine was enhanced by combination of these substances with IBMX-CD. Soluble IBMX-ED as well as soluble IBMXCD and the IBMX suspension enhanced, to a similar extent and in a dose-dependent manner, the IOP reduction induced by catecholamines. IBMX-CD, which has a neutral pH, may be a suitable form of IBMX for future long-term experiments.
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Busch, M.J.W.M., Hoyng, P.F.J. Soluble forms of isobutylmethylxanthine enhance the ocular hypotension induced by catecholamines. Graefe's Arch Clin Exp Ophthalmol 229, 583–586 (1991). https://doi.org/10.1007/BF00203326
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DOI: https://doi.org/10.1007/BF00203326