Abstract
Hereditary nonpolyposis colon cancer (HNPCC) is a heterogeneous disease caused by at least three different genes on chromosomes 2 and 3, and one or more additional chromosomes. We used 19 dinucleotide markers in order to sublocalize further the 3p locus linked to HNPCC, and to order the markers into one map resulting in a panel of markers suitable for linkage studies. Human chromosome 3 mouse hybrids were used to determine the chromosomal position of the markers. Haplotype analysis in two families where the disease is linked to chromosome 3p21–23 was used in order to sublocalize further the region in which the gene is located. Based on our results, the gene has now been localized to the region 3p21.3–23.
This is a preview of subscription content, log in via an institution to check access.
References
Chamberlain JS, Kiousis S (1993) New human DNA polymorphisms submitted to the genome data base. Hum Mol Genet 2:1516
Fishel R, Lescoe M, Rao MRS, Copeland N, Jenkins N, Garber J, Kane M, Kolodner R (1993) The human mutator gene homolog MSH2 and its association with hereditary nonpolyosis colon cancer. Cell 75:1027–1038
Jones MH, Yamakawa K, Nakamura Y (1992) Isolation and characterization of 19 dinucleotide repeat polymorphisms on chromosome 3p. Hum Mol Genet 1:131–133
Leach F, Nicholaides C, Papadopoulos N, Liu B, Jen J, Parsons R, Peltomäki P, Sistonen P, Aaltonen L, Nyström-Lahti M, Guan X-Y, Zhang J, Melzer P, Yu J-W, Kao F-T, Chen D, Cerosaletti K, Fournier K, Todd S, Lewis T, Leach R, Naylor S, Weissenbach J, Mecklin J-P, Järvinen H, Petersen G, Hamilton S, Green J, Jass J, Watson P, Lynch H, Trent J, Chapelle A de la, Kinzler K, Vogelstein B (1993) Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 75:1215–1225
Lindblom A, Tannergård P, Werelius B, Nordenskjöld M (1993) Genetic mapping of a second locus predisposing to hereditary nonpolyposis colon cancer. Nature Genet 5:279–282
Lynch HT, Smyrk TC, Watson P, Lanspa SJ, Lynch JF, Lynch PM, Cavalieri J, Boland CR (1993) Genetics natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: an updated review. Gastroenterology 104:1535–1549
Naylor S, Charles H, Buys C, Carrit B (1993) Report of the Fourth International Workshop on Chromosome 3 Mapping. Cytogenet Cell Genet 65:2–34
Peltomäki P, Aaltonen L, Sistonen P, Pylkyyänen L, Mecklin JP, Järvinen H, Green J, Jass J, Weber J, Leach F, Petersen G, Hamilton S, Chapelle A de la, Vogelstein B (1993) Geneticmapping of a locus predisposing to human colorectal cancer. Science 260:810–812
Saxon P, Stanbridge E (1987) Transfer and selective retension of single specific human chromosomes via microcell-mediated chromosome transfer. Methods Enzymol 151:313–320
Zabarovsky E, Kashuba V, Pokrovskaya E, Zabarovska V, Wang J-Y, Berglund P, Boldog F, Stanbridge E, Sumegi J, Klein G, Winberg G (1993) Alu-PCR approach to isolating NotI-linking clones from the 3p14–p21 region frequently deleted in renal cell carcinoma. Genomics 16:713–719
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tannergård, P., Zabarovsky, E., Stanbridge, E. et al. Sublocalization of a locus at 3p21.3–23 predisposing to hereditary nonpolyposis colon cancer. Hum Genet 94, 210–214 (1994). https://doi.org/10.1007/BF00202874
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00202874