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Linkage analysis of X-linked cleft palate and ankyloglossia in Manitoba Mennonite and British Columbia Native kindreds

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Abstract

A locus (CPX) responsible for X-linked cleft palate and ankyloglossia was previously mapped to the proximal long arm of the X chromosome through DNA marker linkage studies in two large kindreds: an Icelandic family and a British Columbia (B.C.) Native family. In this study, additional linkage analyses have been performed in the B.C. family and in a newly identified Manitoba Mennonite family with X-linked cleft palate and ankyloglossia. The Manitoba CPX locus maps to the same region as Icelandic and B.C. CPX. Two-point disease-tomarker linkage analyses in the Manitoba family indicate a maximum lod score (Zmax) between CPX and DXS349 (Zmax=3.33 at \(\hat \theta\)). In multipoint linkage analysis, combined data from the B.C. and Manitoba families suggest that the most likely location for CPX is at DXS447 in Xq21.1 (multipoint Z=13.5). The support interval for CPX at DXS447 extends approximately from PGK1 to DXYS1 and includes a newly isolated polymorphic locus DXS1109.

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Author notes

  1. Sharon M. Gorski

    Present address: Institute of Molecular Biology and Biochemistry Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada

  2. Paul J. Goodfellow

    Present address: Division of Human Molecular Genetics, Department of Surgery, Washington University School of Medicine, 660 S. Euclid, Box 8109, 63110, St. Louis, MO, USA

Authors and Affiliations

  1. Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada

    Sharon M. Gorski, Karen J. Adams, Patricia H. Birch & Paul J. Goodfellow

  2. Health Sciences Centre, Children's Hospital, Winnipeg, Manitoba, Canada

    Bernard N. Chodirker & Cheryl R. Greenberg

Authors
  1. Sharon M. Gorski
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  2. Karen J. Adams
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  3. Patricia H. Birch
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  4. Bernard N. Chodirker
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  5. Cheryl R. Greenberg
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  6. Paul J. Goodfellow
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Gorski, S.M., Adams, K.J., Birch, P.H. et al. Linkage analysis of X-linked cleft palate and ankyloglossia in Manitoba Mennonite and British Columbia Native kindreds. Hum Genet 94, 141–148 (1994). https://doi.org/10.1007/BF00202859

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  • DOI: https://doi.org/10.1007/BF00202859

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