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Intrathecal baclofen infusion in patients with spasticity and neurogenic bladder disease

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Summary

Nine severely spastic men suffering from neurogenic bladder disease secondary to spinal cord lesion or multiple sclerosis were treated with continuous intrathecal infusion of baclofen using an implanted programmable pump. Bladder function improved in all patients. Significant improvements consisted of an increase in bladder capacity, a decrease in residual volume and a diminution of pelvic floor spasms. Three patients became continent. Intermittent self-catheterization was no longer impeded by adductor spasms. In three cases complete bladder emptying could be achieved. Maximal bladder pressure decreased two subjects, whereas it increased in two others; however for the whole group the changes were not significant.

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References

  1. De Groat WC (1986) Spinal cord projections and neuropeptides in visceral afferent neurons. In: Cervero F, Morrison JFB (eds) Visceral sensation. Progress in brain research, vol. 67, Elsevier, Amsterdam, pp 165–187

    Google Scholar 

  2. De Groat WC (1970) The actions of GABA and related aminoacids on mammalian autonomic ganglia. J Pharmacol Exp Ther 172:384–396

    Google Scholar 

  3. Faigle JW, Keberle H (1972) The chemistry and kinetics of Lioresal. Postgrade Med J [Suppl] 48:9–13

    Google Scholar 

  4. Florante T, Leyson B, Martin BF, Sporer A (1980) Baclofen in the treatment of detrusor sphincter dyssynergia in spinal cord injury patients. J Urol 124:82–84

    Google Scholar 

  5. Kieswetter H, Schober W (1975) Lioresal in the treatment of neurogenic bladder dysfunction. Urol Int 30:63–71

    Google Scholar 

  6. Kontani H, Kawabata Y, Koshiura R (1988) The effect of baclofen on the urinary bladder contraction accompanying micturition in anesthetized rats. Jpn J Pharmacol 46:7–15

    Google Scholar 

  7. Maggi CA, Santicioli P, Meli A (1985) GABA inhibits excitatory neurotransmission in rat pelvic ganglia. J Pharm Pharmacol 37:349–351

    Google Scholar 

  8. Maggi CA, Santicioli P, Giuliani S, Furio M, Conte B, Meli P, Gragnani L, Meli A (1987) The effects of baclofen on spinal and supraspinal micturition reflexes in rats. Naunyn-Schmiedeberg's Arch Pharmacol 336:197–203

    Google Scholar 

  9. Magora F, Shazar N, Drenger B (1989) Urodynamic studies after intrathecal administration of baclofen and morphine in dogs. J Urol 141:143–147

    Google Scholar 

  10. Milne RJ, Foreman RD, Giesler GJ, Wilis WD (1981) Convergence of cutaneous and pelvic visceral nociceptive inputs onto primate spinothalamic neurons. Pain 11:163–183

    Google Scholar 

  11. Morrison JFB (1987) Bladder control: role of higher levels of the central nervous system. In: Torrens M, Morrison JFB (eds) The physiology of the lower urinary tract. Springer, Berlin Heidelberg New York, pp 237–274

    Google Scholar 

  12. Müller H, Zierski J, Dralle D, Borner U, Hoffmann O (1987) The effect of intrathecal baclofen on electrical muscle activity in spasticity. J Neurol 234:348–352

    Google Scholar 

  13. Müller H, Zierski J, Dralle D, Krauß D, Mutschler E (1988) Pharmacokinetics of intrathecal baclofen. In: Müller H, Zierski J, Penn RD (eds) Local-spinal therapy of spasticity. Springer, Berlin Heidelberg New York, pp 223–226

    Google Scholar 

  14. Nanninga JB, Frost F, Penn RD (1989) Effect of intrathecal baclofen on bladder and sphincter function. J Urol 142:101–105

    Google Scholar 

  15. Ochs G, Struppler A, Meyerson BA, Linderoth B, Gybels J, Gardner BP, Teddy P, Jamous A, Weinmann P (1989) Intrathecal baclofen for long-term treatment of spasticity: a multi-centre study. J Neurol Neurosurg Psychiatry 52:933–939

    Google Scholar 

  16. Penn RD, Savoy SM, Corcos D, Latash M, Gottlieb GG, Parke B, Kroin JS (1989) Intrathecal baclofen for severe spinal spasticity. N Engl J Med 320:1517–1521

    CAS  PubMed  Google Scholar 

  17. Sillen U (1980) Central neurotransmitter mechanisms involved in the control of urinary bladder function. Scand J Urol Nephrol [Suppl] 58:1–45

    Google Scholar 

  18. Steers WD (1989) Intrathecal baclofen administration — insights into the regulation of genitourinary function and therapy (editorial) J Urol 141:142

    Google Scholar 

  19. Torrens M (1987) Human physiology. In: Torrens M, Morrison JFB (eds) The physiology of the lower urinary tract. Springer, Berlin Heidelberg New York, pp 336–337

    Google Scholar 

  20. Wein AJ (1984) Pharmacology of the bladder and urethra. In: Mundy AR, Stephenson TP, Wein AJ (eds) Urodynamics. Churchill Livingstone, Edingburgh, pp 26–41

    Google Scholar 

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Kums, J.J.M., Delhaas, E.M. Intrathecal baclofen infusion in patients with spasticity and neurogenic bladder disease. World J Urol 9, 153–156 (1991). https://doi.org/10.1007/BF00202512

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